A rare case of Crohn's disease with involvement of the vulva

Öz

Crohn's disease can involve any part of the gastrointestinal tract, and is a disease that causes transmural inflammation in the areas of involvement. The disease can also have frequent extraintestinal manifestations. The most common skin lesions in patients are erythema nodosum and pyoderma gangrenosum. There are relatively few reported cases in the literature of Crohn's disease with vulvar involvement. In the case of vulvar involvement in Crohn's disease, a greater number of articles and large case series are needed to understand treatment options and the course of the lesions

Anahtar Kelimeler

• Crohn's disease, vulva

Vulva tutulumlu nadir bir Crohn vakası

Öz

Crohn hastalığı gastrointestinal sistemin herhangi bir bölümünü tutabilen ve tutulan bölgelerde transmural inflamasyona yol açabilen bir hastalıktır. Hastalık aynı zamanda sık görülen ekstraintestinal tutulumlarla da gidebilir. Hastalarda en sık görülen deri tutulumu eritema nodozum ve pyoderma gangrenosum şeklindedir. Literatürde vulvar tutulumu olan Crohn hastalığı ile ilgili bildirilen vaka sayısı oldukça azdır. Crohn hastalığında vulvar tutulumun olması durumunda lezyonun seyri ve tedavi seçeneklerini anlamak için daha fazla sayıda bildiriye veya geniş vaka serilerine ihtiyaç vardır.

Anahtar Kelimeler

• Crohn hastalığı, vulva

Kaynakça

1. Sleisenger and Fordtran’s Gastrointestinal and Liver Disease. 8. Edition, Chapter 108. P:2459-90.
2. Schwartz DA, Loftus EV Jr, Tremaine WJ, et al. The natural history of fistulizing Crohn's disease in Olmsted County, Minnesota. Gastroenterology 2002;122:875-80.
3. Foo WC, Papalas JA, Robboy SJ, Selim MA. Vulvar manifestations of Crohn's disease. Am J Dermatopathol 2011;33:588-93.
4. Madnani NA, Desai D, Gandhi N, Khan J. Isolated Crohn's disease of the vulva. Indian J Dermatol Venereol Leprol 2011;77:342-4.
5. Leu S, Sun PK, Collyer J, et al. Clinical spectrum of vulva metastatic Crohn's disease. Dig Dis Sci 2009;54:1565-71.
6. Corbett SL, Walsh CM, Spitzer RF, et al. Vulvar inflammation as the only clinical manifestation of Crohn disease in an 8-year-old girl. Pediatrics 2010;125:e1518-22. Epub 2010 May 10.
7. Siroy A, Wasman J. Metastatic Crohn disease: a rare cutaneous entity. Arch Pathol Lab Med 2012;136:329-32.
8. Lázaro Saéz M, Hernández Martínez A, Bendezú García RÁ, et al. Metastatic Crohn's disease. Response to adalimumab dose intensification. Gastroenterol Hepatol 2012;35:321-5. Epub 2012 Mar 23.

9. Landy J, Peake ST, Akbar A, Hart AL. Vulval Crohn's disease: a tertiary center experience of 23 patients. Inflamm Bowel Dis 2011;17:E77. Epub 2011 Apr 28.