Effects of immune, biochemical and anthropometric function in stomach cancer patients with malnutrition

Öz

In this study, enteral and total parenteral nutrition in patients with gastric cancer was compared with respect to anthropometric, biochemical and immune functions. Materials and Methods: Nutritional support was given to 78 gastric cancer patients in the general surgery clinic of Ankara Numune Training and Research Hospital during the period 1996-2006. For all cases, indices of nutritional measurements were recorded retrospectively. Mann-Whitney U test was used for statistical analysis. A value of p

Anahtar Kelimeler

• Gastric cancer
• malnutrition
• enteral nutrition
• total parenteral nutrition

Mide kanserli olgularda malnütrisyonun immün, biyokimyasal, antropometrik fonksiyonlara etkileri

Öz

Bu çalışma mide kanserli olgularda enteral ve total parenteral nutrisyonun, antropometrik, biyokimyasal ve immün fonksiyonlara olan etkilerini karşılaştırmak için yapılmıştır. Gereç ve Yöntem: Ankara Numune Eğitim ve Araştırma hastanesi 6. Genel Cerrahi Kliniğinde 1996–2006 tarihlerinde mide kanserli 78 olguya nutrisyon desteği verildi. Tüm olguların nutrisyon ile ilgili indeksleri ölçülerek retrospektif olarak kaydedildi. İstatistiksel analiz için Mann Whitney-U testinden yararlanıldı. P

Anahtar Kelimeler

• Mide kanseri
• malnütrisyon
• enteral nutrisyon
• total parenteral nutrisyon

Kaynakça

1. Yalcın S. Gastric cancer in Turkey-a bridge between west and east. Gastrointest Cancer Res. 2009; 3: 29-32.
2. Bozzetti F, Braga M, Gianotti L, et al. Post-operative enteral versus parenteral nutrition in malnourished patients with gastrointestinal cancer: a randomized multicentre trial. Lancet 2001; 538: 1487- 92.
3. Scurtu R, Groza N, Otel O, et al. Quality of life in patients with esophagojejunal anastomosis after total gastrectomy for cancer. Rom J Gastroenterol 2005; 14: 367-72.
4. Liedman B. Symptoms after total gastrectomy on food intake, body composition, bone metabolism, and quality of life in gastric cancer patients-is reconstruction with a reservoir worthwile? Nutri- tion 1999; 15: 677-82.
5. Saito A, Noguchi Y, Yoshikawa T, et al. Gastrectomized patients are in a state of chronic protein malnutrition analysis of 23 amino acids. Hepatogastrology 2001; 48: 585-9.
6. Filipovic’ BF, Gajic’ M, Milinic’ N, et al. Comparison of two nutritio- nal assessment methods in gastroenterology patients. World J Gastroenterol 2010; 16: 1999-2004.
7. Sczepanik AM, Scislo L, Walewska E, et al. The effect of immuno- modulating enteral nutrition on postoperative cytokine profile in gastric cancer patients. Pol Merkur Lekarski 2010; 172: 235-40.
8. Ashley C, Howard L. Evidence base for specialized nutrition sup- port. Nutr Rev 2000; 58: 282-9.

9. Sano Y, Gomez FE, Kang W, et al. Intestinal polymeric immunog- lobulin receptor is affected by type and route of nutrition. JPEN J Parenter Enteral Nutr 2007; 31: 351-7.
10. Guzy C, Schirbel A, Paclik D, et al. Enteral and parenteral nutrition distinctively modulate intestinal permeability and T cell function in vitro. Eur J Nutr 2009; 48: 12-21.
11. Suchner K, Kuhn KS, Furst P. The scientific basis of immunonutriti- on. Proc Nut Soc 2000; 59: 553-63.
12. Stechmiller JK, Childress B, Porter T. Arginine immunonutrition in critically ill patients: a clinical dilemma. Am J Crit Care 2004; 13: 17-23.
13. Nakamura K, Kariyazono H, Komokata T, et al. Influence of pre- operative administration of ω-3 fatty acid-enriched supplement on inflammatory and immune responses in patients undergoing ma- jor surgery for cancer. Nutrition 2005; 21: 639-49.
14. Bragelmann R, Armbrecht U, Rosemeyer D, et al. Nutrient malassi- milation following total gasrectomy. Scand J Gastroenterol Suppl 1996; 218: 26-33.
15. Sategna-Guidetti C, Bianco L. Malnutrition and malabsorbtion af- ter total gastrectomy. A pathophysiologic approach. J Clin Gastro- enterol 1989; 11: 518-24.
16. Kiyama T, Mizutani T, Okuda T, et al. Postoperative changes in body composition after gastrectomy. J Gastrointest Surg 2005; 9: 313-9.
17. Ryan AM, Healy LA, Power DG, et al. Short-term nutritional impli- cations of total gastrectomy for malignancy, and the impact of pa- renteral nutritional support. Clin Nutr 2007; 26: 718-27.
18. Bozzetti, Gianotti L, Braga M, et al. Postoperative complications in gastrointestinal cancer patients: The joint role of the nutritional status and the nutritional support. Clin Nutr 2007; 26: 698-709.
19. Wu GH, Liu ZH, Wu ZH, Wu ZG. Perioperative artificial nutrition in malnourished gastrointestinal cancer patients. World J Gastroente- rol 2006; 12: 2441-4.
20. Daly JM, Weintraub FN, Shou J, et al. Enteral nutrition during mul- timodality therapy in upper gastrointestinal cancer patients. Ann Surg 1995; 221: 327-38.
21. Koike H, Misu K, Hattori N, et al. Postgastrectomy polyneuropathy with thiamine deficiency. J Neurol Neurosurg Psychiatry 2001; 71: 357-62.
22. Tan W, Miao X, Wang L, et al. Significant increase in risk of gas- troesophageal cancer is associated with interaction between pro- moter polymorphisms in thymidylate synthase and serum folate status. Carcinogenesis 2005; 26: 1430-5.