Utility of hematological parameters in predicting the severity and course of acute gallstone pancreatitis

Öz

Background and Aims: Acute pancreatitis is a serious disorder which can lead to severe organ failure and mortality. Early predictors of severe disease course is crucial in the decision making process of the healthcare team. Complete blood count, or hemogram, is a commonly used laboratory test in daily clinical practice. The aim of this study is to define a potential predictive biomarker for acute gallstone pancreatitis amongst the parameters evaluated in complete blood count, hence identifying patients with risk of unfavorable outcomes through an easy-to-use serum marker. Materials and Methods: 233 acute pancreatitis patients secondary to gallstones were evaluated retrospectively. Patient data was gathered from hospital registry system and patient records recorded prospectively at the time of admission. Hematological parameters were compared with severity scoring systems for acute pancreatitis and disease outcomes. Results: White blood cell counts and neutrophil-lymphocyte ratio were correlated with severity scoring systems. Neutrophil-lymphocyte ratio was correlated with a longer hospitalization time and a cut-off point of 5 was found to be useful in predicting disease course. Conclusion: Hematological parameters, particularly neutrophil-lymphocyte ratio, are promising predictive biomarkers for acute gallstone pancreatitis severity.

Anahtar Kelimeler

• Acute pancreatitis
• hemogram
• severity
• neutrophil
• lymphocyte.

Hematolojik parametrelerin akut safra taşı pankreatiti şiddeti ve seyrini öngörmede kullanılabilirliği

Öz

Giriş ve Amaç: Akut pankreatit organ yetmezliği ve ölümle sonuçlanabilen ciddi bir hastalıktır. Sağlık ekibinin karar verme sürecinde, hastalığın şiddetli seyredebileceğini öngören parametreler önemlidir. Tam kan sayımı veya hemogram, günlük klinik pratikte sıklıkla kullanılan bir laboratuvar testidir. Bu çalışmanın amacı tam kan sayımı içerisindeki parametrelerin akut safra taşı pankreatiti için tahmin edici bir belirteç olarak kullanılabilirliğini araştırmaktır. Bu sayede hastalık seyrinin kötü olabileceği hastaları öngörebilecek, kolay kullanılabilir bir serum belirtecinin tanımlanması amaçlanmıştır. Gereç ve Yöntem: Retrospektif inceleme ile safra taşına ikincil akut pankreatit geçiren hastalar saptanmıştır. Hasta verileri hastaların yatışları esnasında prospektif olarak toplanan hastane ve hasta kayıt verilerinden elde edilmiştir. Hematolojik parametreler akut pankreatit için hastalık şiddeti skorlama sistemleri ve hastalık sonlanım noktaları ile karşılaştırılmıştır. Bulgular: Lökosit sayısı ve nötrofil-lenfosit oranı hastalık şiddeti skorlama sistemleri ile korele bulunmuştur. Nötrofil-lenfosit oranı ek olarak uzamış hastane yatışı ile ilişkili bulunmuştur ve eşik değer olarak 5 değerinin hastalık seyrini tahmin ettirmede kullanılabileceği saptanmıştır. Sonuç: Hematolojik parametreler ve özellikle nötrofil-lenfosit oran, akut safra taşı pankreatitinin şiddetini öngörmede kullanılabilecek umut vadeden belirteçlerdir.

Anahtar Kelimeler

• Akut pankreatit
• hemogram
• şiddet
• nötrofil
• lenfosit.

Kaynakça

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