Paroxysmal nocturnal hemoglobinuria: Due to rarely seen cause portal vein thrombosis

Öz

Portal vein thrombosis, which is seen during coagulopathies, vasculitis or myeloproliferative diseases, causes extrahepatic presinusoidal portal hypertension. Paroxysmal nocturnal hemoglobinuria usually causes thrombosis in hepatic veins, but it also rarely causes portal vein thrombosis. A case of paroxysmal nocturnal hemoglobinuria due to portal vein thrombosis is presented.

Anahtar Kelimeler

• Paroxysmal nocturnal hemoglobinuria, portal vein thrombosis

Portal ven trombozunun nadir bir sebebi: Paroksismal nokturnal hemoglobinüri

Öz

Portal ven trombozu, koagülopatiler, vaskülit veya miyeloproliferatif hastalıkların seyrinde görülen, ekstrahepatik presinüzoidal portal hipertansiyon nedenidir. Paroksismal nokturnal hemoglobinüri, daha çok hepatik venlerde tromboza neden olmakla birlikte, portal ven trombozunun nadir nedenleri arasındadır. Burada sebebi paroksismal nokturnal hemoglobinüri olan bir portal ven trombozu olgusu sunuldu.

Anahtar Kelimeler

• Paroksismal nokturnal hemoglobinuri, portal ven trombozu

Kaynakça

1. H Tomizuka, K Hatake, S Kitagawa, et al: Portal vein thrombosis in paroxysmal nocturnal haemoglobinuria. Acta Haematol. 1999; 101: 149-52.
2. B Rotoli, L Luzzatto: Paroxysmal nocturnal hemoglobinuria. Semin Hematol 1989; 26: 201-7.
3. G Socie, J Mary, A Gramont, et al: Paroxysmal nocturnal haemog- lobinuria: long-term follow up and prognostic factors. The Lancet 1996: 348: 573-77.
4. HS Birgens, S Hancke, A Rosenklint, et al: Ultrasonic demonstrati- on of clinical and subclinical hepatic venous thrombosis in paroxys- mal nocturnal haemoglobinuria. British Journal of Haematology, 1996, 64, 737-43.
5. EJ Heitzman, JS Campbell, M Stefanini: Paroxysmal nocturnal he- moglobinuria with hemosiderin nephrosis. Am J Clin Pathol 1953; 23; 975-986.
6. JM Nicolas, F Cervantes, A Lopez-Guillermo, et al: Thrombosis of the portal vein as a complication of paroxysmal nocturnal hemoglo- binuria. Rev Clin Esp. 1990; 187: 287-9.
7. S Issaragrisil, A Piankijagum, Y Tang-Naitrisorana: Corticostero- ids therapy in paroxysmal nocturnal hemoglobinuria. Am J Hema- tol 1987; 25: 77-83.
8. Gayer G., Zandman-Goddard G, Raanani P, et al: Widespread ab- dominal venous thrombosis in paroxysmal nocturnal hemoglobinu- ria diagnosed on CT. Abdom Imaging. 2001; 26: 414-9.

9. D Zimmerman, WR Bell: Venous thrombosis and splenic rupture in paroxysmal nocturnal hemoglobinuria, Am J Med. 1980; 68: 275-9.
10. Grossman JA, McDermott WV Jr.: Paroxysmal nocturnal hemoglo- binuria associated with hepatic and portal venous thrombosis. Am J Surg. 1974; 127: 733-6.
11. L Schmets, H Hagege, C Merlet, et al. Porto-hepatic thrombosis, re- vealing paroxysmal nocturnal hemoglobinuria, followed by regres- sion induced by heparin therapy, Gastroenterol Clin Biol. 1993; 17: 955-8.
12. L Chrobak, P Dulicek, P Zak: Treatment of paroxysmal nocturnal hemoglobinuria. Vnitr Lek. 2001; 47: 880-6.
13. D Valla, D Dhumeaux, G Babany, et al: Hepatic vein thrombosis in Paroxysmal Nocturnal Hemoglobinuria. Gastroenterology 1987; 93: 569-75.