Unveiling subclinical myocardial dysfunction in pediatric Helicobacter pylori infection via speckle tracking echocardiography

Yıl 2026, Cilt: 24 Sayı: 3, 166 - 173, 20.02.2026

Şeyma Kayalı , Deniz Honamlı , Melike Arslan , İrem Türkyılmaz , Necati Balam , Ayhan Kılıç

https://doi.org/10.17941/agd.1841990

https://izlik.org/JA77DC26DH

Öz

Background and Aims: Helicobacter pylori is among the most prevalent infectious agents globally. Recent evidence has highlighted its potential impact beyond the gastrointestinal tract, including possible effects on the cardiovascular system. This study aimed to evaluate myocardial function in children with Helicobacter pylori infection using advanced echocardiographic modalities, particularly two-dimensional speckle tracking echocardiography. Materials and Methods: A total of 54 children diagnosed with Helicobacter pylori infection (mean age: 14 ± 3.1 years) and 37 age-matched healthy controls (mean age: 13.6 ± 2.2 years) were enrolled. Conventional echocardiography, tissue Doppler imaging, and two-dimensional speckle tracking echocardiography were performed to assess left ventricular function. Results: No significant differences were found in traditional echocardiographic parameters between the groups. However, the myocardial performance index measured via tissue Doppler imaging was significantly higher, and mitral S', A', and E'/A' values were significantly lower in the Helicobacter pylori group (p < 0.05). Furthermore, both global longitudinal strain and circumferential strain values obtained from two-dimensional speckle tracking echocardiography were significantly reduced in the patient group (global longitudinal strain: –18.1 ± 0.8 vs. –19.6 ± 1.1; circumferential strain: –19.2 ± 1.2 vs. –21.2 ± 1.0; p < 0.001). Conclusion: Helicobacter pylori infection in children is associated with subclinical alterations in myocardial function, which can be detected using two-dimensional speckle tracking echocardiography and tissue Doppler imaging -derived myocardial performance index. These findings underscore the importance of cardiac follow-up in children diagnosed with Helicobacter pylori infection.

Anahtar Kelimeler

Helicobacter pylori , myocardial dysfunction , subclinical cardiomyopathy , tissue Doppler imaging , strain echocardiography

Helicobacter pylori enfeksiyonu olan çocuklarda subklinik miyokardiyal disfonksiyonun ortaya çıkarılması: Speckle tracking ekokardiyografi ile değerlendirme

https://izlik.org/JA77DC26DH

Öz

Giriş ve Amaç: Helicobacter pylori, dünya çapında en yaygın enfeksiyon etkenlerinden biridir. Son bulgular, gastrointestinal sistemin ötesinde, kardiyovasküler sistem üzerindeki olası etkileri de dahil olmak üzere potansiyel etkisini vurgulamaktadır. Bu çalışma, Helicobacter pylori enfeksiyonu olan çocuklarda miyokardiyal fonksiyonu, özellikle iki boyutlu speckle tracking ekokardiyografi olmak üzere gelişmiş ekokardiyografik yöntemler kullanarak değerlendirmeyi amaçlamaktadır. Gereç ve Yöntem: Helicobacter pylori enfeksiyonu tanısı almış toplam 54 çocuk (ortalama yaş: 14 ± 3.1 yıl) ve yaşları eşleştirilmiş 37 sağlıklı kontrol (ortalama yaş: 13.6 ± 2.2 yıl) çalışmaya dahil edildi. Sol ventrikül fonksiyonunu değerlendirmek için konvansiyonel ekokardiyografi, doku Doppler görüntüleme ve iki boyutlu speckle tracking ekokardiyografi uygulandı. Bulgular: Gruplar arasında geleneksel ekokardiyografik parametrelerde anlamlı bir fark bulunmadı. Ancak, doku Doppler görüntüleme ile ölçülen miyokardiyal performans indeksi Helicobacter pylori grubunda anlamlı derecede yüksek, mitral S', A' ve E'/A' değerleri ise anlamlı derecede düşüktü (p < 0.05). Ayrıca, iki boyutlu speckle tracking ekokardiyografi ile elde edilen hem global longitudinal strain hem de circumferential strain değerleri hasta grubunda istatiksel anlamlı düşük saptandı (global longitudinal strain: –18.1 ± 0.8 vs. –19.6 ± 1.1; circumferential strain: –19.2 ± 1.2 vs. –21.2 ± 1.0; p < 0.001). Sonuç: Çocuklarda Helicobacter pylori enfeksiyonu, iki boyutlu speckle tracking ekokardiyografi ve doku Doppler görüntüleme türevli miyokardiyal performans indeksi kullanılarak tespit edilebilen miyokardiyal fonksiyonda subklinik değişikliklerle ilişkilidir. Bu bulgular, Helicobacter pylori enfeksiyonu tanısı alan çocuklarda kardiyak takibin önemini vurgulamaktadır.

Anahtar Kelimeler

Helicobacter pylori , miyokardiyal disfonksiyon , subklinik kardiyomiyopati , doku Doppler görüntüleme , strain ekokardiyografi

Kaynakça

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