Association of celiac disease with an ICAM-1 gene polymorphism in Turkey

Öz

Background and Aims: Celiac disease is a chronic inflammatory disease of the intestines that occurs after gluten intake in genetically susceptible individuals. The intercellular adhesion molecule -1 gene codes for the intercellular adhesion molecule -1protein, which plays a pivotal role in inflammatory diseases. intercellular adhesion molecule -1 levels have been shown to be increased in celiac disease patients. We aimed to define the relationship between an intercellular adhesion molecule -1 gene polymorphism and celiac disease risk in the Turkish population. Material and Methods: Forty celiac disease patients and 40 healthy controls were included in this study. The G241 R (rs 1799969) polymorphism was analyzed. Results: No statistically significant difference was detected in the frequency of the G241R polymorphism in the intercellular adhesion molecule -1 gene between celiac disease patients and healthy controls. Discussion: Further larger scale analyses are needed to support the findings of the present study.

Anahtar Kelimeler

• Celiac disease,intercellular adhesion molecule -1

Türkiye’de çölyak hastalığı ile ICAM-1 gen polimorfizminin ilişkisi

Öz

Giriş ve Amaç: Çölyak hastalığı, genetik olarak yatkın kişilerde gluten alımından sonra gelişen kronik intestinal inflamatuvar hastalıktır. İntersellüler adezyon molekül-1 geni, inflamatuvar olaylarda rol alan intersellüler adezyon molekül-1’i kodlamaktadır. Çölyak hastalığı olanların intestinal biyopsi ve serumlarında intersellüler adezyon molekül-1 seviyelerinde artış gösterilmiştir. Bu çalışmada amacımız, çölyak hastalığı riski ile intersellüler adezyon molekül-1 gen polimorfizminin ilişkisini araştırmaktı. Gereç ve Yöntem: Çalışmaya 40 çölyak hastası ve 40 sağlıklı kontrol dahil edildi. İntersellüler adezyon molekül-1 genindeki G241R(rs1799969) polimorfizmi analiz edildi. Bulgular: Çölyak hastalığı olanlarla kontrol grubu arasında intersellüler adezyon molekül-1 geninde G241R polimorfizmi yönünden istatistiksel olarak anlamlı fark saptamadık. Sonuç: Bizim çalışmamızdaki sonuçlara göre çölyak hastalığında intersellüler adezyon molekül-1 G241’in rolünü gösteremedik.

Anahtar Kelimeler

• Çölyak hastalığı,intersellüler adezyon molekül-1

Kaynakça

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