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Is there a relationship between ribavirin-induced anemia and viral response rates during HCV therapy?

Yıl 2013, Cilt: 12 Sayı: 1, 1 - 5, 01.04.2013

Öz

Background and Aims:Pegylated interferon and ribavirin combination is the standard therapy for hepatitis C; sustained viral response rates are reported as 42-52% for genotype 1. Hemolytic anemia due to ribavirin is an important side effect. Ribavirin dose reduction leads to reduction in the response to antiviral therapy. We planned a retrospective study to investigate whether anemia due to ribavirin affects the virologic outcomes. Materials and Methods: 164 patients infected with chronic hepatitis C genotype 1 and given pegylated interferon and ribavirin for a 48-week period were included. Drug-induced hemoglobin decrease was defined as >3 g/dl below the pretreatment value. 8.5-10 g/dl was defined as mild and

Kaynakça

  • Global surveillance and control of hepatitis C: report of a WHO consultation organized in collaboration with the Viral Hepatitis Pre- vention Board, Antwerp, Belgium. J Viral Hepat 1999; 6: 35-47.
  • Wasley A, Alter MJ. Epidemiology of hepatitis C: geographic differ- ences and temporal trends. Semin Liver Dis 2000; 20: 1-16.
  • De Franceschi L, Fattovich G, Turrini F, et al. Hemolytic anemia in- duced by ribavirin therapy in patients with chronic hepatitis C virus infection: role of membrane oxidative damage. Hepatology 2000; 31: 997–1004.
  • Russo MW, Fried MW. Side effects of therapy for chronic hepatitis C. Gastroenterology 2003; 124: 1711–9.
  • Kowdley KV. Hematologic side effects of interferon and ribavirin therapy. J Clin Gastroenterol 2005; 39(Suppl 1): S3–8.
  • Maddrey WC. Safety of combination interferon alfa-2b/ribavirin therapy in chronic hepatitis C-relapsed and treatment-naive pa- tients. Semin Liver Dis 1999; 19(Suppl I): 67–75.
  • Stickel F, Helbling B, Heim M. Critical review of the use of eryth- ropoietin in the treatment of anaemia during therapy for chronic hepatitis C. J Viral Hepat 2012; 19: 77–87.
  • Nomura H, Tanimoto H, Kajiwara E, et al. Factors contributing to rib- avirin-induced anemia. J Gastroenterol Hepatol 2004; 19: 1312–7.
  • Oze T, Hiramatsu N, Kurashige N, et al. Early decline of hemoglobin correlates with progression of ribavirin-induced hemolytic anemia during interferon plus ribavirin combination therapy in patients with chronic hepatitis C. J Gastroenterol 2006; 41: 862–72.
  • Reau N, Hadziyannis SJ, Messinger D, Fried MW, Jensen DM. Early predictors of anemia in patients with hepatitis C genotype 1 treat- ed with peginterferon alfa-2a (40 KD) plus ribavirin. Am J Gastro- enterol 2008; 103: 1981–8.
  • Pockros PJ, Shiffman ML, Schiff ER, et al.; PROACTIVE Study Group. Epoetin alfa improves quality of life in anemic HCV-infected patients receiving combination therapy. Hepatology 2004; 40: 1450–8.
  • Afdhal NH, Dieterich DT, Pockros PJ, et al.; Proactive Study Group. Epoetin alfa maintains ribavirin dose in HCV-infected patients: a prospective, double-blind, randomized controlled study. Gastroen- terology 2004; 126: 1302–11.
  • Dieterich DT, Wasserman R, Bräu N, et al. Once-weekly epoetin alfa improves anemia and facilitates maintenance of ribavirin dosing in hepatitis C virus-infected patients receiving ribavirin plus interferon alfa. Am J Gastroenterol 2003; 98: 2491–9.
  • Younossi ZM, Nader FH, Bai C, et al. A phase II dose finding study of darbepoetin and filgrastim for the management of anaemia and neutropenia in chronic hepatitis C treatment. J Viral Hepat 2008; 15: 370–8.
  • Shiffman ML, Salvatore J, Hubbard S, et al. Treatment of chronic hepatitis C virus genotype 1 with peginterferon, ribavirin, and epo- etin alfa. Hepatology 2007; 46: 371–9.
  • Thévenot T, Cadranel JF, Di Martino V, et al. A national French sur- vey on the use of growth factors as adjuvant treatment of chronic hepatitis C. Hepatology 2007; 45: 377–83.
  • Sulkowski MS, Shiffman ML, Afdhal NH, et al.; IDEAL Study Team. Hepatitis C virus treatment related anemia is associated with high- er sustained virologic response rate. Gastroenterology 2010; 139: 1602–11.

Ribavirine bağlı anemi yüksek viral yanıtlarla ilişkili midir?

Yıl 2013, Cilt: 12 Sayı: 1, 1 - 5, 01.04.2013

Öz

Giriş ve Amaç: Pegile interferon ve ribavirin kombinasyonu hepatit C
için standart tedavidir; kalıcı viral yanıt oranları genotip 1 için 42-52%
olarak bildirilmiştir. Ribavirin nedeniyle hemolitik anemi önemli bir yan
etkisidir. Ribavirin dozunun azaltılması antiviral tedaviye yanıtın azalmasına
yol açar. Ribavirin kaynaklı aneminin virolojik sonuçları etkileyip
etkilemediğini araştırmak için retrospektif bir çalışma planladık.Gereç
ve Yöntem: Kronik hepatit C genotip 1 ile enfekte olan ve 48 hafta
süreyle pegile interferon ve ribavirin verilen 164 hasta çalışmaya dahil
edildi. İlaç kaynaklı hemoglobin düşüşü tedavi öncesi değerden >3 gr/
dl düşüş olarak tanımlandı. 8,5-10 gr/dl hafif anemi,

Kaynakça

  • Global surveillance and control of hepatitis C: report of a WHO consultation organized in collaboration with the Viral Hepatitis Pre- vention Board, Antwerp, Belgium. J Viral Hepat 1999; 6: 35-47.
  • Wasley A, Alter MJ. Epidemiology of hepatitis C: geographic differ- ences and temporal trends. Semin Liver Dis 2000; 20: 1-16.
  • De Franceschi L, Fattovich G, Turrini F, et al. Hemolytic anemia in- duced by ribavirin therapy in patients with chronic hepatitis C virus infection: role of membrane oxidative damage. Hepatology 2000; 31: 997–1004.
  • Russo MW, Fried MW. Side effects of therapy for chronic hepatitis C. Gastroenterology 2003; 124: 1711–9.
  • Kowdley KV. Hematologic side effects of interferon and ribavirin therapy. J Clin Gastroenterol 2005; 39(Suppl 1): S3–8.
  • Maddrey WC. Safety of combination interferon alfa-2b/ribavirin therapy in chronic hepatitis C-relapsed and treatment-naive pa- tients. Semin Liver Dis 1999; 19(Suppl I): 67–75.
  • Stickel F, Helbling B, Heim M. Critical review of the use of eryth- ropoietin in the treatment of anaemia during therapy for chronic hepatitis C. J Viral Hepat 2012; 19: 77–87.
  • Nomura H, Tanimoto H, Kajiwara E, et al. Factors contributing to rib- avirin-induced anemia. J Gastroenterol Hepatol 2004; 19: 1312–7.
  • Oze T, Hiramatsu N, Kurashige N, et al. Early decline of hemoglobin correlates with progression of ribavirin-induced hemolytic anemia during interferon plus ribavirin combination therapy in patients with chronic hepatitis C. J Gastroenterol 2006; 41: 862–72.
  • Reau N, Hadziyannis SJ, Messinger D, Fried MW, Jensen DM. Early predictors of anemia in patients with hepatitis C genotype 1 treat- ed with peginterferon alfa-2a (40 KD) plus ribavirin. Am J Gastro- enterol 2008; 103: 1981–8.
  • Pockros PJ, Shiffman ML, Schiff ER, et al.; PROACTIVE Study Group. Epoetin alfa improves quality of life in anemic HCV-infected patients receiving combination therapy. Hepatology 2004; 40: 1450–8.
  • Afdhal NH, Dieterich DT, Pockros PJ, et al.; Proactive Study Group. Epoetin alfa maintains ribavirin dose in HCV-infected patients: a prospective, double-blind, randomized controlled study. Gastroen- terology 2004; 126: 1302–11.
  • Dieterich DT, Wasserman R, Bräu N, et al. Once-weekly epoetin alfa improves anemia and facilitates maintenance of ribavirin dosing in hepatitis C virus-infected patients receiving ribavirin plus interferon alfa. Am J Gastroenterol 2003; 98: 2491–9.
  • Younossi ZM, Nader FH, Bai C, et al. A phase II dose finding study of darbepoetin and filgrastim for the management of anaemia and neutropenia in chronic hepatitis C treatment. J Viral Hepat 2008; 15: 370–8.
  • Shiffman ML, Salvatore J, Hubbard S, et al. Treatment of chronic hepatitis C virus genotype 1 with peginterferon, ribavirin, and epo- etin alfa. Hepatology 2007; 46: 371–9.
  • Thévenot T, Cadranel JF, Di Martino V, et al. A national French sur- vey on the use of growth factors as adjuvant treatment of chronic hepatitis C. Hepatology 2007; 45: 377–83.
  • Sulkowski MS, Shiffman ML, Afdhal NH, et al.; IDEAL Study Team. Hepatitis C virus treatment related anemia is associated with high- er sustained virologic response rate. Gastroenterology 2010; 139: 1602–11.
Toplam 17 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Engin Altıntaşž Bu kişi benim

Serkan Yaraşž - Bu kişi benim

Fehmi Ateşž Bu kişi benim

Bünyamin Sarıtaşž Bu kişi benim

Orhan Sezgin Bu kişi benim

Gülhan Örekici - Bu kişi benim

Yayımlanma Tarihi 1 Nisan 2013
Yayımlandığı Sayı Yıl 2013 Cilt: 12 Sayı: 1

Kaynak Göster

APA Altıntaşž, E., -, S. Y., Ateşž, F., Sarıtaşž, B., vd. (2013). Ribavirine bağlı anemi yüksek viral yanıtlarla ilişkili midir?. Akademik Gastroenteroloji Dergisi, 12(1), 1-5.

test-5