BibTex RIS Kaynak Göster

The frequency of gastroesophageal reflux disease in patients admitting to primary health care centers in Turkey

Yıl 2008, Cilt: 7 Sayı: 3, 137 - 143, 01.12.2008

Öz

Background and Aims: Gastroesophageal reflux disease is a common gastrointestinal disorder and its prevalence differs depending on the population studied. There are few data on the epidemiology of gastroesophageal reflux disease in Turkey. The aim of the study was to determine the frequency and epidemiologic features of gastroesophageal reflux disease in patients admitting to primary health care centers in Turkey. Materials and Methods: The study was carried out in a population of 7520 patients randomly selected among those admitted to primary health care centers in 32 different cities in Turkey. Patients were categorized into two groups [gastrointestinal system or non- gastrointestinal system] depending on the main symptoms on admission. The prevalence and epidemiologic features of gastroesophageal reflux disease were investigated via face-to-face questionnaire to a total of 2203 randomly selected patients from both of the groups. The diagnosis of gastroesophageal reflux disease was based on the Rome-II criteria. Results: Among the 7520 patients participating in the study, 2157 (31.5%) were admitted with gastrointestinal system symptoms and 5363 (41%) with non- gastrointestinal system symptoms. Of the 2157 patients with gastrointestinal system symptoms, the questionnaire was administered in a randomly selected 1461 patients and a diagnosis of gastroesophageal reflux disease was reached in 560 (38.3%). Of the 5363 patients with non- gastrointestinal system symptoms, a questionnaire was administered in a randomly selected 742 patients and a diagnosis of dyspepsia was reached in 189 (25.4%). The prevalence of dyspepsia was 33.9% in the whole group. Most of the patients were female (69.3%) and the mean age was 44 ± 14 years. Heartburn (60.1%), regurgitation (59.1%), retrosternal pain (35.5%) and cough (27.6%) were the most frequent symptoms. Sixteen percent of the patients experienced heartburn once a month, 30% once a week, 39.5% more than once a week, and 13.9% daily. There were no significant associations between gastroesophageal reflux disease and marital status, smoking, or tea, alcohol and coffee consumption. Economic status (p

Kaynakça

  • Dent J, Brun J, Fendrick Am, et al. An evidence-based appraisal of reflux disease management- the Genval Workshop Report. Gut 1999;44(Suppl.2):1-16.
  • Locke GR III, Talley NJ, Fett SL, et al. Risk factors associated with symptoms of gastroesophageal reflux. Am J Med 1999;106:642-9.
  • Isolauri J, Laippala P. Prevalence of symptoms suggestive of gastroesophageal reflux disease in adult population. Ann Med 1995;106:642-9.
  • Kennedy T, Jones R. The prevalence of gastroesophageal reflux symptoms in a UK population and the consultation behaviour of patients with these symptoms. Aliment Pharmacol Ther 2000;14:1589-94.
  • Ronkainen J, Aro P, Storskrubb T, et al. Barrett’s esophagus is rare in the Svedish general population despite a high prevalence of GERD: a random population-based study (Kalixanda). Gastroenterology 2004;126 (Suppl2):A308.
  • Diaz-Rubio M, Morena-Elola-Olaso C, Rey E, et al. Symptoms of gastroesophageal reflux: prevalence, severity, duration and associated factors in a Spanish population. Aliment Pharmacol Ther 2004;19:95-105.
  • Locke GR III, Talley NJ, Fett SL, et al. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted Country, Minnesota. Gastroenterology 1997;112:1448-56.
  • Goh K. Changing epidemiology of gastroesophageal reflux disease in the Asian-Pacific region: an overview. J Gastroenterol Hepatol 2004;19:22-5.
  • Fock KM, Tally N, Hunt R , et al. Report of the Asia-Pacific consensus on the management of gastroesophageal reflux disease. J Gastroenterol Hepatol 2004;19:357-67.
  • Bor S, Mand›rac›oğlu A, Kitapç›oğlu G, et al. Gastroesophageal reflux disease in a low-income region in Turkey. Am J Gastroenterol 2005;100:759-65.
  • Segal I. The gastroesophageal reflux disease complex in subSaharan Africa. Eur J Cancer Prev 2001;10:209-12.
  • Stanghellini V. Three-month prevalence rates of gastrointestinal symptoms and the influence of demographic factors: results from the Domestic/International Gastroenterology Surveillance Study (DIGEST). Scand J Gastroenterol Suppl 1999;231:20-8.
  • Moayyedi P, Axon ATR. Review article: gastro-oesophageal reflux disease-the extent of the problem. Aliment Pharmacol Ther 2005;22 (Suppl.1):11-9.
  • Wong BCY, Kinoshita Y. Systematic review on epidemiology of gastroesophageal reflux disease in Asia. Clin Gastroenterol Hepatol 2006;4:398-407.
  • Fung WP. Gastric acid secretion in Chinese with particular reference to the dose of histamine required for maximal stimulation. Gut 1970;11:955-61.
  • El Serag HB, Sonnenberg A, Jamal MM, et al. Corpus gastritis is protective against reflux oesphagitis. Gut 1999;45:181-5.
  • Kang JY, Ho KY. Different prevalences of reflux oesophagitis and hiatus hernia among dyspeptic patients in England and Singapore. Eur J Gastroenterol Hepatol 1999;11:845-50.
  • Spechler SJ, Jain SK, Tendler DA, et al. Racial differences in the frequency of symptoms and complications of gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2002;16:1795-1800.
  • Mohammed I, Cherkas LF, Riley SA, et al. Genetic influences in gastro-eosophageal reflux disease: a twin study. Gut 2003;52:1085-89.
  • Drosman DA, Li Z, Andruzzi E, et al. U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact. Dig Dis Sci 1993;38:1569-80.
  • Raiha I, Impivaara O, Seppala M, et al. Determinants of symptoms suggestive of gastroesophageal reflux disease in the elderly. Scand J Gastroenterology 1993;28:1011-4.
  • Kay L, Jorgensen T, Jensen KH. Epidemiology of abdominal symptoms in a random population: prevalence, incidence, and natural history. Eur J Epidemiol 1994;10:559-66.
  • Nilsson M, Johnsen R, Ye W, et al. Lifestyle related risk factors in the aetiology of gastro-oesophageal reflux. Gut 2004;53:1730-5.
  • Kahrilas PJ, Gupta RR. The effect of cigarette smoking on salivation and oesophageal acid clearance. J Lab Clin Med 1989;114:431-8.
  • Ponce J, Vegazo O, Beltran B, et al. Prevalence of gastrooesophageal reflux disease in Spain and associated risk factors. Aliment Pharmacol Ther 2006;23:175-83.
  • Chen M, Xiong L, Chen H, et al. Prevalence, risk factors and impact of gastrooesophageal reflux disease symptoms: A population-based study in South China. Scand J Gastroenterol 2005;40:759-67.
  • Nocon M, Willich SN. Prevalence and sociodemographics of reflux symptoms in Germany-results from a national survey. Aliment Pharmacol Ther 2006;23:1601-5.
  • A Gallup survey on heartburn across American. Princeton. N.J.: The Gallup Organization;1988.

Türkiye'de birinci basamak sağlık kurumlarına başvuran hastalarda gastroözofageal reflü hastalığı görülme sıklığı

Yıl 2008, Cilt: 7 Sayı: 3, 137 - 143, 01.12.2008

Öz

Giriş ve Amaç: Gastroözofageal reflü hastalığı, gastrointestinal sistemin sık görülen hastalıklarından birisi olup, prevalansı çalışmanın yapıldığı topluma göre değişmektedir. Türkiye'de gastroözofageal reflü hastalığı epidemiyolojisi hakkında sınırlı bilgi vardır. Bu çalışma da Türkiye'de birinci basamak sağlık kuruluşlarına başvuran hastalarda gastroözofageal reflü hastalığı sıklığını saptamak ve epidemiyolojik özelliklerini belirlemek amaçlanmıştır. Gereç ve Yöntem: Çalışma Türkiye'nin 32 farklı ilindeki birinci basamak sağlık kuruluşlarına başvuran olgular arasından rasgele seçilen 7520 olguda gerçekleştirilmiştir. Hastalar başvurudaki ana yakınmalarına göre gastrointestinal sistem ve gastrointestinal sistem dışı semptomlarla başvuranlar olmak üzere iki guruba ayrıldıktan sonra, her iki gurup içinden rastgele seçilen 2203 olguya yüz yüze görüşülerek anket yapılmış ve gastroözofageal reflü hastalığı prevalansı ve epidemiyolojik özellikleri araştırılmıştır. Gastroözofageal reflü hastalığı tanısı Roma-II kriterlerine göre konulmuştur. Bulgular: Çalışmaya katılan 7520 hastanın 2157'si (%31.5) gastrointestinal sistem semptomları ile doktora başvururken, 5363'ü (%68.5) gastrointestinal sistem dışı yakınmalar ile başvurmuştur. Gastrointestinal sistem yakınmaları ile başvuran 2157 hasta arasından rasgele anket yapılan 1461 olgunun 560'ında (%38.3), gastrointestinal sistem dışı yakınmalar ile başvuran 5363 olgu arasından rasgele anket yapılan 742 olgunun 189'unda (%25.4) gastroözofageal reflü hastalığı tanısı konulmuştur. Gastroözofageal reflü hastalı ğı prevalansı %33.9 olarak bulunmuştur. Hastaların çoğunluğu kadın olup (%69.3), yaş ortalaması 44±14 yıldır. Retrosternal yanma (%60.1), regürjitasyon (%59.1), retrosternal ağrı (%35.5) ve öksürük (%27.6) en sık görülen yakınmalardır. Hastaların %16.6'sı retrosternal yanmayı ayda bir, %30'u haftada bir, %39.5'i haftada birden fazla, %13.9'u her gün yaşadığını ifade etmektedir. Medeni durum, çay, sigara, kahve ve alkol kullanımı ile gastroözofageal reflü hastalığı arasında istatistiksel anlamlı bir ilişki bulunmamıştır. Ekonomik durum (p < 0,01) ve eğitim düzeyi (p < 0,01) ile gastroözofageal reflü hastalığı arasında anlamlı pozitif bir korelasyon vardır. Sonuç: Sonuç olarak, ülkemizde gastroözofageal reflü hastalığı batılı ülkelerde rastlanan sıklığa yakın oranlarda görülmekte olup retrosternal yanma ve regürjitasyon başvuruda en sık rastlanan şikayetler olarak ortaya çıkmaktadır.

Kaynakça

  • Dent J, Brun J, Fendrick Am, et al. An evidence-based appraisal of reflux disease management- the Genval Workshop Report. Gut 1999;44(Suppl.2):1-16.
  • Locke GR III, Talley NJ, Fett SL, et al. Risk factors associated with symptoms of gastroesophageal reflux. Am J Med 1999;106:642-9.
  • Isolauri J, Laippala P. Prevalence of symptoms suggestive of gastroesophageal reflux disease in adult population. Ann Med 1995;106:642-9.
  • Kennedy T, Jones R. The prevalence of gastroesophageal reflux symptoms in a UK population and the consultation behaviour of patients with these symptoms. Aliment Pharmacol Ther 2000;14:1589-94.
  • Ronkainen J, Aro P, Storskrubb T, et al. Barrett’s esophagus is rare in the Svedish general population despite a high prevalence of GERD: a random population-based study (Kalixanda). Gastroenterology 2004;126 (Suppl2):A308.
  • Diaz-Rubio M, Morena-Elola-Olaso C, Rey E, et al. Symptoms of gastroesophageal reflux: prevalence, severity, duration and associated factors in a Spanish population. Aliment Pharmacol Ther 2004;19:95-105.
  • Locke GR III, Talley NJ, Fett SL, et al. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted Country, Minnesota. Gastroenterology 1997;112:1448-56.
  • Goh K. Changing epidemiology of gastroesophageal reflux disease in the Asian-Pacific region: an overview. J Gastroenterol Hepatol 2004;19:22-5.
  • Fock KM, Tally N, Hunt R , et al. Report of the Asia-Pacific consensus on the management of gastroesophageal reflux disease. J Gastroenterol Hepatol 2004;19:357-67.
  • Bor S, Mand›rac›oğlu A, Kitapç›oğlu G, et al. Gastroesophageal reflux disease in a low-income region in Turkey. Am J Gastroenterol 2005;100:759-65.
  • Segal I. The gastroesophageal reflux disease complex in subSaharan Africa. Eur J Cancer Prev 2001;10:209-12.
  • Stanghellini V. Three-month prevalence rates of gastrointestinal symptoms and the influence of demographic factors: results from the Domestic/International Gastroenterology Surveillance Study (DIGEST). Scand J Gastroenterol Suppl 1999;231:20-8.
  • Moayyedi P, Axon ATR. Review article: gastro-oesophageal reflux disease-the extent of the problem. Aliment Pharmacol Ther 2005;22 (Suppl.1):11-9.
  • Wong BCY, Kinoshita Y. Systematic review on epidemiology of gastroesophageal reflux disease in Asia. Clin Gastroenterol Hepatol 2006;4:398-407.
  • Fung WP. Gastric acid secretion in Chinese with particular reference to the dose of histamine required for maximal stimulation. Gut 1970;11:955-61.
  • El Serag HB, Sonnenberg A, Jamal MM, et al. Corpus gastritis is protective against reflux oesphagitis. Gut 1999;45:181-5.
  • Kang JY, Ho KY. Different prevalences of reflux oesophagitis and hiatus hernia among dyspeptic patients in England and Singapore. Eur J Gastroenterol Hepatol 1999;11:845-50.
  • Spechler SJ, Jain SK, Tendler DA, et al. Racial differences in the frequency of symptoms and complications of gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2002;16:1795-1800.
  • Mohammed I, Cherkas LF, Riley SA, et al. Genetic influences in gastro-eosophageal reflux disease: a twin study. Gut 2003;52:1085-89.
  • Drosman DA, Li Z, Andruzzi E, et al. U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact. Dig Dis Sci 1993;38:1569-80.
  • Raiha I, Impivaara O, Seppala M, et al. Determinants of symptoms suggestive of gastroesophageal reflux disease in the elderly. Scand J Gastroenterology 1993;28:1011-4.
  • Kay L, Jorgensen T, Jensen KH. Epidemiology of abdominal symptoms in a random population: prevalence, incidence, and natural history. Eur J Epidemiol 1994;10:559-66.
  • Nilsson M, Johnsen R, Ye W, et al. Lifestyle related risk factors in the aetiology of gastro-oesophageal reflux. Gut 2004;53:1730-5.
  • Kahrilas PJ, Gupta RR. The effect of cigarette smoking on salivation and oesophageal acid clearance. J Lab Clin Med 1989;114:431-8.
  • Ponce J, Vegazo O, Beltran B, et al. Prevalence of gastrooesophageal reflux disease in Spain and associated risk factors. Aliment Pharmacol Ther 2006;23:175-83.
  • Chen M, Xiong L, Chen H, et al. Prevalence, risk factors and impact of gastrooesophageal reflux disease symptoms: A population-based study in South China. Scand J Gastroenterol 2005;40:759-67.
  • Nocon M, Willich SN. Prevalence and sociodemographics of reflux symptoms in Germany-results from a national survey. Aliment Pharmacol Ther 2006;23:1601-5.
  • A Gallup survey on heartburn across American. Princeton. N.J.: The Gallup Organization;1988.
Toplam 28 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Dilek Oğuz Bu kişi benim

Aydın Şeref Köksal Bu kişi benim

Ali Özden Bu kişi benim

Yayımlanma Tarihi 1 Aralık 2008
Yayımlandığı Sayı Yıl 2008 Cilt: 7 Sayı: 3

Kaynak Göster

APA Oğuz, D., Köksal, A. Ş., & Özden, A. (2008). Türkiye’de birinci basamak sağlık kurumlarına başvuran hastalarda gastroözofageal reflü hastalığı görülme sıklığı. Akademik Gastroenteroloji Dergisi, 7(3), 137-143.

test-5