Hepatoid adenocarcinoma with liver metastasis: A case report
Yıl 2007,
Cilt: 6 Sayı: 2, 97 - 99, 01.08.2007
İlker Turan
Fulya Günşar
Gül Yüce
Öz
Hepatoid adenocarcinoma is a special type of extra-hepatic adenocarcinoma, and has a special morphologic similarity to hepatocellular carcinoma. The stomach is one of the most common localizations of hepatoid adenocarcinomas. A 47-year-old man was referred to our clinic due to detection of the large solid masses in the liver. A very high level of serum alpha-fetoprotein was determined, but the ultrasonographic examination of the abdomen showed noncirrhotic liver parenchyma and the viral serologic markers were negative. Percutaneous liver biopsy was performed. The pathological examination of the biopsy material revealed metastatic hepatoid type adenocarcinoma. Upper gastrointestinal endoscopy showed gastric ulcers in the antrum. Histological examination of the antral biopsy specimens revealed malignant epithelial tumor.
Kaynakça
- Roberts CC, Colby TV, Batts KP. Carcinoma of the stomach with hepatocyte differentiation (hepatoid adenocarcinoma). Mayo Clin Proc. 1997; 72: 1154-60.
- Terracciano LM, Glatz K, Mhawech P. et al. Hepatoid adenocarci- noma with liver metastasis mimicking hepatocellular carcinoma: an immunohistochemical and molecular study of eight cases. Am J Surg Pathol. 2003; 27: 1302-12.
- Gao YB, Zhang DF, Jin XL. et al. Preliminary study on the clinical and pathological relevance of gastric hepatoid adenocarcinoma. J Dig Dis. 2007; 8: 23-8.
- Ishikura H, Kishimoto T, Andachi H. et al. Gastrointestinal hepatoid adenocarcinoma: venous permeation and mimicry of hepatocellular carcinoma, a report of four cases. Histopathology. 1997; 31: 47-54.
- Carlinfante G, Foschini MP, Pasquinelli G. et al. Hepatoid carcino- ma of the lung: a case report with immunohistochemical, ultrastruc- tural and in-situ hybridization findings. Histopathology. 2000; 37: 88-9.
- Foschini MP, Baccarini P, Dal Monte PR. et al. Albumin gene exp- ression in adenocarcinomas with hepatoid differentiation. Virchows Arch. 1998; 433: 537-41.
- Gitlin D, Perricelli A, Gitlin GM. Synthesis of -fetoprotein by liver, yolk sac, and gastrointestinal tract of the human conceptus. Cancer Res. 1972; 32: 979-82.
- Inagawa S, Shimazaki J, Hori M. et al. Hepatoid adenocarcinoma of the stomach. Gastric Cancer. 2001; 4: 43-52.
- Ishikura H, Fukasawa Y, Ogasawara K. et al. An AFP-producing gastric carcinoma with features of hepatic differentiation. A case re- port. Cancer. 1985; 56: 840-8.
- Chang YC, Nagasue N, Abe S. et al. alpha Fetoprotein producing early gastric cancer with liver metastasis: report of three cases. Gut. 1991; 32: 542-5.
- Ishikura H, Kirimoto K, Shamoto M. et al. Hepatoid adenocarcino- mas of the stomach. An analysis of seven cases. Cancer. 1986; 58: 119-26.
- Motoyama T, Aizawa K, Watanabe H. et al. alpha-Fetoprotein pro- ducing gastric carcinomas: a comparative study of three different subtypes. Acta Pathol Jpn. 1993; 43: 654-61.
- Aizawa K, Motoyama T, Suzuki S. et al. Different characteristics of hepatoid and non-hepatoid alpha-fetoprotein-producing gastric carcinomas: an experimental study using xenografted tumors. Int J Cancer. 1994; 58: 430-5.
- Kang GH, Kim YI. Alpha-fetoprotein-producing gastric carcinoma presenting focal hepatoid differentiation in metastatic lymph nodes. Virchows Arch. 1998; 432: 85-7.
- Ooi A, Nakanishi I, Sakamoto N. et al. Alpha-fetoprotein (AFP)-pro- ducing gastric carcinoma. Is it hepatoid differentiation? Cancer. 1990; 65: 1741-7.
- Nagai E, Ueyama T, Yao T. et al. Hepatoid adenocarcinoma of the stomach. A clinicopathologic and immunohistochemical analysis. Cancer. 1993; 72: 1827-35.
- Kanda T, Yoshida H, Mamada Y. et al. Resection of liver metastases from an alpha-fetoprotein-producing gastric cancer. J Nippon Med Sch. 2005; 72: 66-70.
- Yachnin S. The immunosuppressive properties of alpha-fetoprotein: a brief overview. Ann N Y Acad Sci. 1983; 417: 105-7.
Karaciğere hepatoid adenokarsinoma metastazı: Olgu sunumu
Yıl 2007,
Cilt: 6 Sayı: 2, 97 - 99, 01.08.2007
İlker Turan
Fulya Günşar
Gül Yüce
Öz
Hepatoid adenokarsinoma morfolojik olarak hepatosellüler karsinomaya çok benzeyen özel bir tip ekstra-hepatik adenokarsinomadır. Hepatoid adenokarsinomaların en sık tespit edildiği yerlerden biri midedir. Karaciğerde büyük kitlesel lezyonlar tespit edilmesi nedeniyle 47 yaşında erkek hasta kliniğimize refere edilmişti. Serum alfa feto-protein düzeyleri çok yüksek saptanan olguda batın ultrasonografisinde karaciğer parankimi sirotik değildi ve viral serolojik göstergeler negatifti. Perkütan karaciğer biyopsisi yapıldı. Biyopsi materyalinin patolojik incelemesinde metastatik hepatoid tip adenokarsinoma metastazı saptandı. Üst gastrointestinal sistem endoskopisinde antrumda ülserler izlendi. Antral biyopsi örneklerinin histolojik incelemesinde epitelial malign tümör tespit edildi.
Kaynakça
- Roberts CC, Colby TV, Batts KP. Carcinoma of the stomach with hepatocyte differentiation (hepatoid adenocarcinoma). Mayo Clin Proc. 1997; 72: 1154-60.
- Terracciano LM, Glatz K, Mhawech P. et al. Hepatoid adenocarci- noma with liver metastasis mimicking hepatocellular carcinoma: an immunohistochemical and molecular study of eight cases. Am J Surg Pathol. 2003; 27: 1302-12.
- Gao YB, Zhang DF, Jin XL. et al. Preliminary study on the clinical and pathological relevance of gastric hepatoid adenocarcinoma. J Dig Dis. 2007; 8: 23-8.
- Ishikura H, Kishimoto T, Andachi H. et al. Gastrointestinal hepatoid adenocarcinoma: venous permeation and mimicry of hepatocellular carcinoma, a report of four cases. Histopathology. 1997; 31: 47-54.
- Carlinfante G, Foschini MP, Pasquinelli G. et al. Hepatoid carcino- ma of the lung: a case report with immunohistochemical, ultrastruc- tural and in-situ hybridization findings. Histopathology. 2000; 37: 88-9.
- Foschini MP, Baccarini P, Dal Monte PR. et al. Albumin gene exp- ression in adenocarcinomas with hepatoid differentiation. Virchows Arch. 1998; 433: 537-41.
- Gitlin D, Perricelli A, Gitlin GM. Synthesis of -fetoprotein by liver, yolk sac, and gastrointestinal tract of the human conceptus. Cancer Res. 1972; 32: 979-82.
- Inagawa S, Shimazaki J, Hori M. et al. Hepatoid adenocarcinoma of the stomach. Gastric Cancer. 2001; 4: 43-52.
- Ishikura H, Fukasawa Y, Ogasawara K. et al. An AFP-producing gastric carcinoma with features of hepatic differentiation. A case re- port. Cancer. 1985; 56: 840-8.
- Chang YC, Nagasue N, Abe S. et al. alpha Fetoprotein producing early gastric cancer with liver metastasis: report of three cases. Gut. 1991; 32: 542-5.
- Ishikura H, Kirimoto K, Shamoto M. et al. Hepatoid adenocarcino- mas of the stomach. An analysis of seven cases. Cancer. 1986; 58: 119-26.
- Motoyama T, Aizawa K, Watanabe H. et al. alpha-Fetoprotein pro- ducing gastric carcinomas: a comparative study of three different subtypes. Acta Pathol Jpn. 1993; 43: 654-61.
- Aizawa K, Motoyama T, Suzuki S. et al. Different characteristics of hepatoid and non-hepatoid alpha-fetoprotein-producing gastric carcinomas: an experimental study using xenografted tumors. Int J Cancer. 1994; 58: 430-5.
- Kang GH, Kim YI. Alpha-fetoprotein-producing gastric carcinoma presenting focal hepatoid differentiation in metastatic lymph nodes. Virchows Arch. 1998; 432: 85-7.
- Ooi A, Nakanishi I, Sakamoto N. et al. Alpha-fetoprotein (AFP)-pro- ducing gastric carcinoma. Is it hepatoid differentiation? Cancer. 1990; 65: 1741-7.
- Nagai E, Ueyama T, Yao T. et al. Hepatoid adenocarcinoma of the stomach. A clinicopathologic and immunohistochemical analysis. Cancer. 1993; 72: 1827-35.
- Kanda T, Yoshida H, Mamada Y. et al. Resection of liver metastases from an alpha-fetoprotein-producing gastric cancer. J Nippon Med Sch. 2005; 72: 66-70.
- Yachnin S. The immunosuppressive properties of alpha-fetoprotein: a brief overview. Ann N Y Acad Sci. 1983; 417: 105-7.