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Association of celiac disease with an ICAM-1 gene polymorphism in Turkey

Yıl 2017, Cilt: 16 Sayı: 1, 26 - 28, 24.04.2017

Öz

Background and Aims: Celiac disease is a chronic inflammatory disease of the intestines that occurs after gluten intake in genetically susceptible individuals. The intercellular adhesion molecule -1 gene codes for the intercellular adhesion molecule -1protein, which plays a pivotal role in inflammatory diseases. intercellular adhesion molecule -1 levels have been shown to be increased in celiac disease patients. We aimed to define the relationship between an intercellular adhesion molecule -1 gene polymorphism and celiac disease risk in the Turkish population. Material and Methods: Forty celiac disease patients and 40 healthy controls were included in this study. The G241 R (rs 1799969) polymorphism was analyzed. Results: No statistically significant difference was detected in the frequency of the G241R polymorphism in the intercellular adhesion molecule -1 gene between celiac disease patients and healthy controls. Discussion: Further larger scale analyses are needed to support the findings of the present study.

Kaynakça

  • 1. Ferguson A, MacDonald TT, McClure JP, Holden RJ. Cell-mediated immunity to gliadin within the small-intestinal mucosa in coeliac disease. Lancet 1975;1:895-7. 2. Sollid LM. Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol 2002;2:647-55. 3. Sollid LM, Markussen G, Ek J, et al. Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer. J Exp Med 1989;169:345-50. 4. Monsuur AJ, de Bakker PI, Alizadeh BZ, et al. Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. Nat Genet 2005;37:1341-4. 5. Curley CR, Monsuur AJ, Wapenaar MC, et al. A functional candidate screen for coeliac disease genes. Eur J Hum Genet 2006;14:1215-22. 6. van de Stolpe A, van der Saag PT. Intercellular adhesion molecule-1. J Mol Med (Berl) 1996;74:13-33. 7. Sturgess RP, Macartney JC, Makgoba MW, et al. Differential upregulation of intercellular adhesion molecule-1 in coeliac disease. Clin Exp Immunol 1990;82:489-92. 8. Jelínková L, Tucková L, Sánchez D, et al. Increased levels of circulating ICAM-1, E-selectin, and IL-2 receptors in celiac disease. Dig Dis Sci 2000;45:398-402. 9. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition. Revised criteria for diagnosis of coeliac disease. Arch Dis Child 1990;65:909-11. 10. Abel M, Cellier C, Kumar N, Cerf-Bensussan N, et al. Hum adulthood-onset celiac disease is associated with intercellular adhesion molecule-1 (ICAM-1) gene polymorphism. Immunol 2006;67:612-7. 11. Kaur G, Rapthap CC, Kumar S, et al. Polymorphism in L-selectin, E-selectin and ICAM-1 genes in Asian Indian pediatric patients with celiac disease. Hum Immunol 2006;67:634-8. 12. Dema B, Martínez A, Polanco I, et al. ICAM1 R241 is not associated with celiac disease in the Spanish population. Hum Immunol 2008;69:675-8.

Türkiye’de çölyak hastalığı ile ICAM-1 gen polimorfizminin ilişkisi

Yıl 2017, Cilt: 16 Sayı: 1, 26 - 28, 24.04.2017

Öz

Giriş ve Amaç: Çölyak hastalığı, genetik olarak yatkın kişilerde gluten alımından sonra gelişen kronik intestinal inflamatuvar hastalıktır. İntersellüler adezyon molekül-1 geni, inflamatuvar olaylarda rol alan intersellüler adezyon molekül-1’i kodlamaktadır. Çölyak hastalığı olanların intestinal biyopsi ve serumlarında intersellüler adezyon molekül-1 seviyelerinde artış gösterilmiştir. Bu çalışmada amacımız, çölyak hastalığı riski ile intersellüler adezyon molekül-1 gen polimorfizminin ilişkisini araştırmaktı. Gereç ve Yöntem: Çalışmaya 40 çölyak hastası ve 40 sağlıklı kontrol dahil edildi. İntersellüler adezyon molekül-1 genindeki G241R(rs1799969) polimorfizmi analiz edildi. Bulgular: Çölyak hastalığı olanlarla kontrol grubu arasında intersellüler adezyon molekül-1 geninde G241R polimorfizmi yönünden istatistiksel olarak anlamlı fark saptamadık. Sonuç: Bizim çalışmamızdaki sonuçlara göre çölyak hastalığında intersellüler adezyon molekül-1 G241’in rolünü gösteremedik.

Kaynakça

  • 1. Ferguson A, MacDonald TT, McClure JP, Holden RJ. Cell-mediated immunity to gliadin within the small-intestinal mucosa in coeliac disease. Lancet 1975;1:895-7. 2. Sollid LM. Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol 2002;2:647-55. 3. Sollid LM, Markussen G, Ek J, et al. Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer. J Exp Med 1989;169:345-50. 4. Monsuur AJ, de Bakker PI, Alizadeh BZ, et al. Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. Nat Genet 2005;37:1341-4. 5. Curley CR, Monsuur AJ, Wapenaar MC, et al. A functional candidate screen for coeliac disease genes. Eur J Hum Genet 2006;14:1215-22. 6. van de Stolpe A, van der Saag PT. Intercellular adhesion molecule-1. J Mol Med (Berl) 1996;74:13-33. 7. Sturgess RP, Macartney JC, Makgoba MW, et al. Differential upregulation of intercellular adhesion molecule-1 in coeliac disease. Clin Exp Immunol 1990;82:489-92. 8. Jelínková L, Tucková L, Sánchez D, et al. Increased levels of circulating ICAM-1, E-selectin, and IL-2 receptors in celiac disease. Dig Dis Sci 2000;45:398-402. 9. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition. Revised criteria for diagnosis of coeliac disease. Arch Dis Child 1990;65:909-11. 10. Abel M, Cellier C, Kumar N, Cerf-Bensussan N, et al. Hum adulthood-onset celiac disease is associated with intercellular adhesion molecule-1 (ICAM-1) gene polymorphism. Immunol 2006;67:612-7. 11. Kaur G, Rapthap CC, Kumar S, et al. Polymorphism in L-selectin, E-selectin and ICAM-1 genes in Asian Indian pediatric patients with celiac disease. Hum Immunol 2006;67:634-8. 12. Dema B, Martínez A, Polanco I, et al. ICAM1 R241 is not associated with celiac disease in the Spanish population. Hum Immunol 2008;69:675-8.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Konular Sağlık Kurumları Yönetimi
Bölüm Makaleler
Yazarlar

Fatma Ebru Akın Bu kişi benim

Gülay Güleç Ceylan Bu kişi benim

Aylin Demirezer Bolat Bu kişi benim

Öykü Tayfur Yürekli Bu kişi benim

Mustafa Tahtacı

Eyüp Selvi Bu kişi benim

Naciye Şemnur Büyükaşık Bu kişi benim

Osman Ersoy3

Yayımlanma Tarihi 24 Nisan 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 16 Sayı: 1

Kaynak Göster

APA Akın, F. E., Ceylan, G. G., Demirezer Bolat, A., Tayfur Yürekli, Ö., vd. (2017). Türkiye’de çölyak hastalığı ile ICAM-1 gen polimorfizminin ilişkisi. Akademik Gastroenteroloji Dergisi, 16(1), 26-28. https://doi.org/10.17941/agd.315845

test-5