Araştırma Makalesi
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Effects of Malnutrition on Quality of Life in Inflammatory Bowel Disease

Yıl 2024, Cilt: 23 Sayı: 2, 54 - 60, 27.08.2024

Öz

Background and Aims: In the course of inflammatory bowel diseases, malnutrition is a common condition for both the disease itself and some other reasons, such as the drugs used. Malnutrition can also lead to an increase in patients' risk of morbidity and mortality, an increase in treatment costs and impairment in quality of life. Therefore, early detection, treatment and determination of the risk factors for malnutrition are important for inflammatory bowel diseases patients. In our study, we aimed to determine the frequency of malnutrition, the effects of malnutrition on the overall quality of life, and the demographic, clinical and laboratory features of patients with inflammatory bowel diseases. Materials and Methods: Patients diagnosed with inflammatory bowel diseases who were admitted to Gastroenterology Outpatient Clinic between 2020 and 2021 were screened for the risk of malnutrition by MUST score. The overall quality of life of the patients was investigated using the EQ-5D index. Results: The risk of malnutrition was high in 11% of the patients in the Chron’s disease group and in 10% of the patients in the ulcerative colitis group. In general quality of life evaluation, EQ-5D index was 0.83 ± 0.16 and EQ-5D VAS score was 63.75 ± 19.88 in the Chron’s disease group; in the ulcerative colitis group, the EQ-5D index was 0.81 ± 0.19 and the EQ-5D VAS score was 67.99 ± 22.09, and when both groups were compared in terms of general quality of life, no statistically significant difference was observed (p = 0.355, p = 0.202, respectively). When the remission and activation groups of patients diagnosed with Crohn's and ulcerative colitis were compared in terms of malnutrition and general quality of life, no statistically significant difference was found between both groups (activation and remission). Conclusion: No significant correlation was found with the activation status of the patients, their malnutrition and general quality of life. Evaluation of weight status, nutritional status and general quality of life in inflammatory bowel diseases patients in polyclinics gives us the chance to prevent possible malnutrition and deterioration of general quality of life during the course of the disease with prophylactic measures. Considering the effect of malnutrition on the prognosis of diseases, evaluation of inflammatory bowel diseases patients in terms of malnutrition is very important.

Kaynakça

  • 1. Addolorato G, Capristo E, Stefanini GF, Gasbarrini G. Inflammatory bowel disease: a study of the association between anxiety and depression, physical morbidity, and nutritional status. Scand J Gastroenterol. 1997;32(10):1013-21.
  • 2. Bischoff SC, Escher J, Hébuterne X, et al. ESPEN practical guideline: Clinical Nutrition in inflammatory bowel disease. Clin Nutr. 2020;39(3):632-53.
  • 3. Mijac DD, Janković GL, Jorga J, Krstić MN. Nutritional status in patients with active inflammatory bowel disease: prevalence of malnutrition and methods for routine nutritional assessment. Eur J Intern Med. 2010;21(4):315-9.
  • 4. Norman K, Kirchner H, Lochs H, Pirlich M. Malnutrition affects quality of life in gastroenterology patients. World J Gastroenterol. 2006;12(21):3380-5.
  • 5. Satsangi J, Silverberg MS, Vermeire S, Colombel JF. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut. 2006;55(6):749-53.
  • 6. Lewis JD, Chuai S, Nessel L, et al. Use of the Noninvasive Components of the Mayo Score to Assess Clinical Response in Ulcerative Colitis. Inflamm Bowel Dis. 2008;14(12):1660-6.
  • 7. Harvey RF, Bradshaw JM. A simple index of Crohn's-disease activity. Lancet. 1980;1(8167):514.
  • 8. Karsegard VL, Ferlay O, Maisonneuve N, et al. Malnutrition Universal Screening Tool (MUST)]. Rev Med Suisse Romande. 2004;124(10):601-5. French.
  • 9. Krabbe P, Weijnen T. Guidelines for analysing and reporting EQ-5D outcomes. In: Brooks R, Rabin R, de Charro F. (Eds). The Measurement and Valuation of Health Status Using EQ-5D: A European Perspective: Evidence from the EuroQol BIOMED Research Programme. Dordrecht: Springer; 2003;7-19.
  • 10. Rajendran N, Kumar D. Role of diet in the management of inflammatory bowel disease. World J Gastroenterol. 2010;16(12):1442-8.
  • 11. Yamamoto T, Nakahigashi M, Saniabadi AR. Review article: diet and inflammatory bowel disease--epidemiology and treatment. Aliment Pharmacol Ther. 2009;30(2):99-112.
  • 12. Csontos ÁA, Molnár A, Piri Z, Pálfi E, Miheller P. Malnutrition risk questionnaire combined with body composition measurement in malnutrition screening in inflammatory bowel disease. Rev Esp Enferm Dig. 2017;109(1):26-32.
  • 13. Rahman A, Williams P, Sandhu A, Mosli MH. Malnutrition Universal Screening Tool (MUST) predicts disease activity in patients with Crohn‟s disease. Canadian Journal of Clinic Nutrition. September 2016.
  • 14. Valentini L, Schaper L, Buning C, et al. Malnutrition and impaired muscle strength in patients with Crohn's disease and ulcerative colitis in remission. Nutrition. 2008;24(7-8):694-702.
  • 15. Mowat C, Cole A, Windsor A, et al; IBD Section of the British Society of Gastroenterology. Guidelines for the management of inflammatory bowel disease in adults. Gut. 2011;60(5):571-607.
  • 16. Andersson RE, Olaison G, Tysk C, Ekbom A. Appendectomy is followed by increased risk of Crohn's disease. Gastroenterology. 2003;124(1):40-6.
  • 17. Andersson RE, Olaison G, Tysk C, Ekbom A. Appendectomy and protection against ulcerative colitis. N Engl J Med. 2001;344(11):808-14.

İnflamatuvar Bağırsak Hastalığında Malnütrisyonun Yaşam Kalitesi Üzerine Etkisi

Yıl 2024, Cilt: 23 Sayı: 2, 54 - 60, 27.08.2024

Öz

Giriş ve Amaç: İnflamatuvar bağırsak hastalıkları (İBH) seyrinde, hem hastalığın kendisinden hem de kullanılan ilaçlar gibi bazı nedenlerden dolayı malnütrisyon sık görülen bir durumdur. Malnütrisyon ayrıca hastaların morbidite ve mortalite riskinde artışa, tedavi maliyetlerinde artışa ve yaşam kalitesinde bozulmaya neden olabilir. Bu nedenle inflamatuvar bağırsak hastalığı olanlar için erken teşhis, tedavi ve malnütrisyona ilişkin risk faktörlerinin belirlenmesi önemlidir. Çalışmamızda inflamatuvar bağırsak hastalığı olanlarda malnütrisyon sıklığını, malnütrisyonun genel yaşam kalitesine etkilerini, demografik, klinik ve laboratuvar özelliklerini belirlemeyi amaçladık. Gereç ve Yöntem: 2020-2021 yılları arasında Gastroenteroloji Polikliniği'ne başvuran inflamatuvar bağırsak hastalığı tanısı alan hastalar MUST skoru ile malnütrisyon riski açısından tarandı. Hastaların genel yaşam kalitesi EQ-5D indeksi kullanılarak araştırıldı. Bulgular: Crohn hastalığı grubundaki hastaların %11'inde, ülseratif kolit (ÜK) grubundaki hastaların ise %10'unda malnütrisyon riski yüksekti. Genel yaşam kalitesi değerlendirmesinde Crohn hastalığı grubunda EQ-5D indeksi 0.83 ± 0.16, EQ-5D VAS skoru 63.75 ± 19.88; ülseratif kolit grubunda EQ-5D indeksi 0.81 ± 0.19 ve EQ-5D VAS skoru 67.99 ± 22.09 olup, her iki grup genel yaşam kalitesi açısından karşılaştırıldığında istatistiksel olarak anlamlı bir fark gözlenmedi (sırasıyla p = 0.355, p = 0.202). Crohn hastalığı ve ülseratif kolit tanısı alan hastaların remisyon ve aktivasyon grupları malnütrisyon ve genel yaşam kalitesi açısından karşılaştırıldığında her iki grup arasında (aktivasyon ve remisyon) istatistiksel olarak anlamlı fark bulunmadı. Sonuç: Hastaların aktivasyon durumları, malnütrisyon ve genel yaşam kalitesi arasında anlamlı bir ilişki bulunamadı. İnflamatuvar bağırsak hastalığı hastalarında polikliniklerde kilo durumu, beslenme durumu ve genel yaşam kalitesinin değerlendirilmesi, profilaktik önlemlerle hastalığın seyri sırasında olası malnütrisyon ve genel yaşam kalitesinin bozulmasını önleme şansı vermektedir. Malnütrisyonun hastalıkların prognozu üzerindeki etkisi dikkate alındığında inflamatuvar bağırsak hastalığı hastalarının malnütrisyon açısından değerlendirilmesi oldukça önemlidir.

Kaynakça

  • 1. Addolorato G, Capristo E, Stefanini GF, Gasbarrini G. Inflammatory bowel disease: a study of the association between anxiety and depression, physical morbidity, and nutritional status. Scand J Gastroenterol. 1997;32(10):1013-21.
  • 2. Bischoff SC, Escher J, Hébuterne X, et al. ESPEN practical guideline: Clinical Nutrition in inflammatory bowel disease. Clin Nutr. 2020;39(3):632-53.
  • 3. Mijac DD, Janković GL, Jorga J, Krstić MN. Nutritional status in patients with active inflammatory bowel disease: prevalence of malnutrition and methods for routine nutritional assessment. Eur J Intern Med. 2010;21(4):315-9.
  • 4. Norman K, Kirchner H, Lochs H, Pirlich M. Malnutrition affects quality of life in gastroenterology patients. World J Gastroenterol. 2006;12(21):3380-5.
  • 5. Satsangi J, Silverberg MS, Vermeire S, Colombel JF. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut. 2006;55(6):749-53.
  • 6. Lewis JD, Chuai S, Nessel L, et al. Use of the Noninvasive Components of the Mayo Score to Assess Clinical Response in Ulcerative Colitis. Inflamm Bowel Dis. 2008;14(12):1660-6.
  • 7. Harvey RF, Bradshaw JM. A simple index of Crohn's-disease activity. Lancet. 1980;1(8167):514.
  • 8. Karsegard VL, Ferlay O, Maisonneuve N, et al. Malnutrition Universal Screening Tool (MUST)]. Rev Med Suisse Romande. 2004;124(10):601-5. French.
  • 9. Krabbe P, Weijnen T. Guidelines for analysing and reporting EQ-5D outcomes. In: Brooks R, Rabin R, de Charro F. (Eds). The Measurement and Valuation of Health Status Using EQ-5D: A European Perspective: Evidence from the EuroQol BIOMED Research Programme. Dordrecht: Springer; 2003;7-19.
  • 10. Rajendran N, Kumar D. Role of diet in the management of inflammatory bowel disease. World J Gastroenterol. 2010;16(12):1442-8.
  • 11. Yamamoto T, Nakahigashi M, Saniabadi AR. Review article: diet and inflammatory bowel disease--epidemiology and treatment. Aliment Pharmacol Ther. 2009;30(2):99-112.
  • 12. Csontos ÁA, Molnár A, Piri Z, Pálfi E, Miheller P. Malnutrition risk questionnaire combined with body composition measurement in malnutrition screening in inflammatory bowel disease. Rev Esp Enferm Dig. 2017;109(1):26-32.
  • 13. Rahman A, Williams P, Sandhu A, Mosli MH. Malnutrition Universal Screening Tool (MUST) predicts disease activity in patients with Crohn‟s disease. Canadian Journal of Clinic Nutrition. September 2016.
  • 14. Valentini L, Schaper L, Buning C, et al. Malnutrition and impaired muscle strength in patients with Crohn's disease and ulcerative colitis in remission. Nutrition. 2008;24(7-8):694-702.
  • 15. Mowat C, Cole A, Windsor A, et al; IBD Section of the British Society of Gastroenterology. Guidelines for the management of inflammatory bowel disease in adults. Gut. 2011;60(5):571-607.
  • 16. Andersson RE, Olaison G, Tysk C, Ekbom A. Appendectomy is followed by increased risk of Crohn's disease. Gastroenterology. 2003;124(1):40-6.
  • 17. Andersson RE, Olaison G, Tysk C, Ekbom A. Appendectomy and protection against ulcerative colitis. N Engl J Med. 2001;344(11):808-14.
Toplam 17 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Gastroenteroloji ve Hepatoloji
Bölüm Makaleler
Yazarlar

1. shamkhal Safarov Bu kişi benim 0009-0000-8709-9768

Azar Abiyev 0000-0002-9840-7348

Abdullah Emre Yıldırım 0000-0002-4386-9297

Yayımlanma Tarihi 27 Ağustos 2024
Gönderilme Tarihi 12 Mart 2024
Kabul Tarihi 11 Haziran 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 23 Sayı: 2

Kaynak Göster

APA Safarov, 1., Abiyev, A., & Yıldırım, A. E. (2024). Effects of Malnutrition on Quality of Life in Inflammatory Bowel Disease. Akademik Gastroenteroloji Dergisi, 23(2), 54-60. https://doi.org/10.17941/agd.1514621

test-5