Romatoid Artritte Plazma sTRAIL Düzeyi ile Hastalık Aktivitesi İlişkisi

Öz

Amaç: Çalışmanın amacı romatoid artritte plazmada çözünmüş TNF ilişkili apoptoz tetikleyici ligand sTRAIL düzeyinin saptanması ve sTRAIL düzeyinin hastalık aktivitesi ile ilişkisinin araştırılmasıdır. Gereç ve Yöntemler: 19 Romatoid artrit RA hastası ve kontrol grubu olarak belirlenen 31 primer Sjögren sendromu pSS hastası ile 24 sağlıklı kişi çalışmaya dahil edildi. RA hastalarının hastalık aktivitesi, hastalık aktivite skoru-28 DAS-28 ile hesaplandı. Plazma sTRAIL düzeyi immunoenzimatik yöntem ELISA ile ölçüldü. Bulgular: Ortalama sTRAIL düzeyi RA hastalarında 1751 ± 635 pg/ml , pSS hastaları 1234 ± 625 pg/ml ve sağlıklı kontrol 1181 ± 304 pg/ml grubundan daha yüksek olarak ölçüldü p=0.002 . RA hastalarında DAS-28 ve sTRAIL düzeyi arasında bir korelasyon saptanmadı. Ayrıca sTRAIL düzeyi ile hastalık aktivitesini gösteren ESR ve CRP arasında da korelasyon saptanmadı. Sonuç: RA’li hastaların sTRAIL düzeyleri hastalık aktivitesinden bağımsız olarak anlamlı düzeyde artmaktadır. Bu bulgular sTRAIL’in RA patogenezinde önemli bir rol alabileceğini göstermektedir

Anahtar Kelimeler

• TNF ilişkili apoptoz tetikleyici ligand, Romatoid artrit, Sjögren sendromu

The Relationship Between Plasma sTRAIL Level and Disease Activity in Rheumatoid Arthritis

Abstract

Objective: The purpose of this study was to investigate the plasma soluble tumour necrosis factor related apoptosis-inducing ligand sTRAIL level in rheumatoid arthritis RA and to evaluate the relationship between sTRAIL and disease activity. Material and Methods: 19 RA patients, and as a control group 31 primary Sjogren’s syndrome pSS patients and 24 healthy subjects were included in the study. Disease activity of RA patients was calculated by the Disease Activity Score-28 DAS-28 . Plasma sTRAIL concentrations were measured by the enzyme linked immunosorbent assay ELISA .Results: Mean plasma sTRAIL concentration in RA patients 1751 ± 635 pg/ml was higher than in disease control patients with pSS 1234 ± 625 pg/ml and in healthy controls 1181 ± 304 pg/ml p=0.002 . In RA patients, there was no correlation between mean DAS-28 score and plasma sTRAIL levels. And also, there was no correlation between sTRAIL levels and laboratory parameters indicating disease activity such as the erythrocyte sedimentation rate ESR and C-reactive protein CRP . conclusion: Plasma sTRAIL levels were significantly higher in RA regardless of disease activity. These findings suggest that sTRAIL may have an important role in the pathogenesis of rheumatoid arthritis

Keywords

• TNF-related apoptosis inducing ligand, Rheumatoid arthritis, Sjogren’s syndrome

Kaynakça

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