Obez Prepubertal Çocuklarda Ortalama Trombosit Hacmi

Öz

Amaç: Bir trombosit aktivasyon belirteci olan ortalama trombosit hacmi OTH , erişkinlerde, obezite ve kardiyovasküler hastalıklar ile ilişkili bulunmuştur. Ancak çocukluk yaş grubunda OTH ile obezite arasındaki ilişkiyi inceleyen az sayıda çalışma mevcuttur. Bu kesitsel çalışmanın amacı; obez prepubertal çocukların OTH değerleri ile sağlıklı kontrollerin OTH değerlerini karşılaştırmaktır. Gereç ve Yöntemler: Çocuk endokrin polikliniğinde obezite tanısı almış, yaşları 6-10,5 yıl arasında değişen 51 prepubertal çocuk ve çocuk endokrin polikliniğine genel kontrol amacıyla başvurmuş sağlıklı ve normal tartılı 46 prepubertal çocuk çalışmaya dahil edilmiştir. Bulgular: Trombosit sayısı, OTH ve trombosit dağılım genişliği TDG parametrelerinde, hasta ve kontrol grupları arasında istatistiksel olarak anlamlı fark bulunmadı p>0,05 . Bu üç parametre ile; vücut kütle indeksi, bel çevresi, kalça çevresi, kan şekeri, insülin, tiroid fonksiyon testleri, karaciğer fonksiyon testleri ve lipid profi li arasında herhangi bir korelasyon saptanmadı p>0,05 . Sonuç: Ortalama trombosit hacmi çocukluk yaş grubunda obezite ile ilişkili gözükmemektedir. Bu sonucun desteklenmesi için çocuklarda yapılacak daha geniş örneklemli prospektif çalışmalara ihtiyaç vardır

Anahtar Kelimeler

• Ortalama trombosit hacmi, Obezite, Çocuk

Mean Platelet Volume in Obese Prepubertal Children

Abstract

Objective: Mean platelet volume MPV , a marker of platelet activation, has been found to be associated with obesity and cardiovascular diseases in adults. However, only a few studies thus far have investigated the relationship between MPV and obesity during childhood. The aim of this crosssectional study was to compare the MPV values of obese prepubertal children with those of healthy controls.Material and Methods: Fifty-one prepubertal children aged 6 to 10.5 years diagnosed with obesity at the pediatric endocrinology clinic and 46 healthy prepubertal children with normal weight were enrolled in this study. Results: Platelet count, MPV and platelet distribution width PDW did not differ signifi cantly between the patient and control groups p>0.05 . There was no correlation between any of these three parameters and the body mass index, waist circumference, hip circumference, blood sugar, insulin, thyroid function tests, liver function tests and lipid profi le p>0.05 . Conclusion: Mean platelet volume does not seem to be associated with obesity in children. There is a need for large scale prospective studies in the pediatric age group to support this finding

Keywords

• Mean platelet volume, Obesity, Child

Kaynakça

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