Survival Analysis in N2 + Patients for Whom Surgical Resection Was Performed

Abstract

Objective: This study aimed to demonstrate survival assessment and determine survival of the number of metastatic stations which N2 lymph node station was involvement.Material and Methods: Ninety six 10.6% patients with N2 lymph node metastasis in 901 patients who had been operated for Non-Small Cell Lung Cancer NSCLC at hospital from January 2009 to October 2013, were included in the study. The patients were analized under two main headings. In the first title the survival analysis was performed depending on single station or multiple stations of lymph node involvement. In the second title patients were divided into 5 groups according to metastatic lymph node stations. Group 1 was composed of superior No 2&4 stations metastases 20.8% , Group 2 was aorticopulmonary window No 5&6 stations metastases 26% , Group 3 was central No 7 station 13.5% , Group 4 was inferior No 8&9 stations metastases 14.6% and Group 5 was multiple station metastases were determined 25% .Results: Average survival time was 33.3 months and the median survival time was 30.8 months. In patients with mediastinal lymph node metastasis, comparison of survival difference in single-multiple stations; median survival of 55.7 months in single station and median survival of 25.5 months in multiple stations has been found. Single station involvement was determined to caused statistically significant better survival p

Keywords

• Lung cancer surgery
• Metastatic N2 lymph nodes
• Survival

Cerrahi Rezeksiyon Uygulanmış N2 + Hastalarda Sağkalım Analizi

Öz

Amaç: Bu çalışma, operasyon sonrası metastatik olduğu saptanan N2 lenf nodu istasyonlarının sağkalım değerlendirmesini ve hangi N2 istasyon tutulumunun sağkalımının daha iyi olduğunun gösterilmesini amaçlamıştır.Gereç ve Yöntemler: Hastanemizde Ocak 2009-Ekim 2013 tarihleri arasında küçük hücreli dışı primer akciğer kanseri nedeni ile opere edilen 901 hastadan N2 lenf nodu metastazı tespit edilmiş 96 %10,6 hasta çalışmamıza dahil edildi. Hastalar iki ana başlık altında incelendi. İlk başlıkta, lenf nodu istasyonu tutulumunun tek istasyon ve multipl istasyon olmasına göre incelendi. İkinci başlıkta ise metastatik lenf nodu istasyonlarına göre 5 gruba ayrılarak tutulumların sağkalıma etkileri değerlendirildi. Grup 1ʼde süperior No 2&4 istasyon metastazları % 20,8 , Grup 2ʼde aortikopulmoner pencere No 5&6 metastazları %26 , Grup 3’te santral No 7 istasyon metastazı %13,5 , Grup 4ʼde inferior No 8&9 istasyon metastazları %14,6 ve Grup 5'de multipl istasyon metastazları incelenmiştir %25 .Bulgular: Ortalama sağkalım süresi 33,3 ay ve median sağkalım süresi 30,8 ay olarak bulundu. Mediastinal lenf nodlarında metastaz tespit edilen hastalarda, tek-multipl istasyon sağkalım farkı karşılaştırmasında tek istasyon tutulumunda 55,7 ay ortalama sağkalım ve multipl istasyon tutulumunda ise 25,5 ay ortalama sağkalım olduğu tespit edildi. Tek istasyon tutulumunun istatistiksel olarak anlamlı pİ0,05 olarak daha iyi sağkalıma neden olduğu belirlendi. Grup 1 ve 2’nin Grup 3 ve 5 ile karşılaştırmasında istatistiksel olarak anlamlı pİ0,05 olduğu ve daha iyi sağkalıma neden olduğu görüldü.Sonuç: Tek istasyon N2 tutulumunda multipl istasyon tutulumuna göre daha iyi sağkalım süreleri beklenmelidir. Özellikle 7 numaralı istasyon tutulumunda azalmış sağkalım görüldüğünden pre-peri operatif süreçte mutlaka örneklenmesi gerekmektedir

Anahtar Kelimeler

• Akciğer kanseri cerrahisi
• N2 lenf nodu metastazı
• Sağkalım

Kaynakça

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