Ratlarda Pentoksifilinin Kontrast Nefropatisi Üzerine Koruyucu Etkileri

Öz

Amaç: Antioksidan ve immüno-modülatör etkileri olan pentoksifilinin PTX , renal iskemi-reperfüzyon hasarını azalttığı gösterilmiştir. PTX’in kontrast kaynaklı nefropatinin CIN gelişmesine karşı koruyucu bir rolü olup olmadığını araştırdık.Gereç ve Yöntemler: Toplam 24 tane wistar-albino dişi sıçan rastgele-altışarlı kontrol C , kontrast madde CM , PTX ve PTX + CM şeklinde dört gruba ayrıldı. Kontrol ve CM grupları haricindekilere 5 gün boyunca günde bir kez PTX verildi. CIN, 48 saat dehidrasyondan sonra intravenöz yüksek ozmolar kontrast madde olan -diatrizoatla 6 mL/kg indüklendi. Bazal ve post-CIN böbrek fonksiyon parametreleri, inflamatuar parametreler, serum ve renal doku oksidatif stres belirteçleri ileri oksidasyon protein ürünü ve malondialdehid serum seviyeleri ve histopatolojik lezyonlar değerlendirildi.Bulgular: Serum kreatinin ve kan üre nitrojen düzeylerindeki artış ve kreatin klerensinde azalma sadece CM grubunda anlamlıydı P

Anahtar Kelimeler

• Kontrast nefropatisi, Pentoksifilin, Böbrek, Önleyici, Oksidatif stres

The Protective Effects of Pentoxifylline on Contrast Induced Nephropathy in Rats

Abstract

Objective: Pentoxifylline PTX , which has antioxidant and immunomodulatory effects, has been shown to attenuate renal ischemia-reperfusion injury. We aimed to investigate whether PTX might have a preventive role against the development of contrast induced nephropathy CIN .Material and Methods: A total of 24 Wistar-albino female rats were randomly divided into four groups n=6 each as follows; control C , contrast material CM , PTX, and PTX+CM. Except the control and CM groups, the groups were given PTX once daily orally for 5 days. CIN was induced by administration of intravenous high-osmole contrast material-diatrizoate 6 mL/kg after 48 hour of dehydration. Basal and post-CIN kidney function parameters, inflammatory parameters, serum and renal tissue oxidative stress markers serum levels of advanced oxidation protein product and malondialdehyde , and histopathological lesions were assessed.Results: The increase in serum creatinine and blood urea nitrogen levels was significantly higher only in the CM group P

Keywords

• Contrast nephropathy, Pentoxifylline, Kidney, Preventive, Oxidative stress

Kaynakça

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