Çocukluk Çağı Migreni ile Subkortikal Gri Madde Yapılarının İlişkisi

Öz

Amaç: Migren, çocuklardaki tekrarlayıcı baş ağrısının en sık sebebidir. Migren patogenezi halen aydınlatılamamıştır. Çalışmalarda, çoğunluğu yetişkinlerde olmak üzere, subkortikal gri cevher yapılarının migren patogenezindeki rolü araştırılmış olup farklı sonuçlar sunulmuştur. Çalışma ile migren patogenezinde subkortikal gri cevher yapılarının rolünün belirlenmesi amaçlanmıştır.Gereç ve Yöntemler: Çalışmaya normal manyetik rezonans görüntülemeye MRG sahip olan, benzer yaş ve cinsiyet dağılımında 28 çocukluk çağı migren ÇÇM hastası ile 41 kontrol hastası alındı. Migren hastaları aynı zamanda auralı migren 8 hasta ve aurasız migren 20 hasta grubu olarak da sınıflandırıldı T1 ağırlıklı görüntülerden ‘volBrain’ programı kullanılarak, subkortikal gri cevher volümleri elde edildi ve karşılaştırıldı.Bulgular: Çalışma sonucunda ÇÇM hastalarının putamen volümleri sağlıklı kontrol grubuna oranla anlamlı olarak artmış bulundu total putamen p

Anahtar Kelimeler

• Migren, Çocuk, Putamen, Volüm

The Relationship Between Childhood Migraine and Subcortical Gray Matter Structures

Abstract

Objective: Migraine is the most common cause of recurrent headache in children. The pathophysiology of migraine remains unclear. In recent studies, mostly in adults, the role of subcortical gray matter structures in migraine pathophysiology was investigated and various results were presented. The aim of this study was to determine the role of subcortical gray matter structures in the pathogenesis of migraine.Material and Methods: The study included 28 childhood migraine patients and 41 control patients with similar age and gender distribution and normal magnetic resonance imaging MRI findings. Migraine patients were also classified as migraine with aura 8 patients and migraine without aura 20 patients . Subcortical gray matter volumes were obtained and compared from T1-weighted images using the volBrain program.Results: Putamen volumes of childhood migraine patients were significantly increased compared to healthy controls total putamen p

Keywords

• Migraine, Childhood, Putamen, Volume

Kaynakça

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