Fibromiyaljili Hastalarda Vitamin Dʼnin Ağrı Şiddeti, Yaşam Kalitesi, Depresyon ve Uyku Üzerine Etkileri

Öz

Amaç: Bu çalışmanın amacı, serum 25 hidroksivitamin D konsantrasyonlarının Fibromiyalji Sendromuʼndaki FMS semptomlar üzerindeki rolünü araştırmaktır.Gereç ve Yöntemler: FMS tanısı almış 80 kadın hasta serum 25-hidroksivitamin D 25OHD konsantrasyonuna göre 2 gruba ayrıldı: 25OHD

Anahtar Kelimeler

• Depresyon, Fibromiyalji, Serum 25 hidroksivitamin D, Uyku, Semptom şiddeti

Effects of Vitamin D on Pain Severity, Quality of Life, Depression and Sleep in Patients with Fibromyalgia

Abstract

Objective: The aim of this study was to investigate the role of 25-hydroxyvitamin D 25OHD concentrations on symptoms in the Fibromyalgia Syndrome FMS .Material and Methods: 80 female patients diagnosed with FMS were divided into 2 groups according to serum 25OHD concentration: 25OHD

Keywords

• Depression, Fibromyalgia, Serum 25-hydroxyvitamin D, Sleep, Symptom severity

Kaynakça

1. Wolfe F, Clauw DJ, Fitzcharles M-A, Goldenberg DL, Häuser W, Katz RL, Mease PJ, Russell AS, Russell IJ, Walitt B. 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum 2016; 46:319-29.
2. Ellis SD, Kelly ST, Shurlock JH, Hepburn ALN. The role of vitamin D testing and replacement in fibromyalgia: A systematic literature review. BMC Rheumatol 2018; 2:28.
3. Baygutalp NK, Baygutalp F, Şeferoğlu B, Bakan E. The relation between serum vitamin D levels and clinical findings of fibromyalgia syndrome. Dicle Med J 2014; 41(3):446-50.
4. Abeles AM, Pillinger MH, Solitar BM, Abeles M. Nar- rative review: The pathophysiology of fibromyalgia. Ann Intern Med 2007; 146(10):726-34.
5. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM. Guidelines for preventing and treating vitamin D deficiency and insufficiency revisited. J Clin Endocrinol Metab 2012; 97(4):1153-8.
6. Okyay R, Koçyiğit B, Gürsoy S. Vitamin D levels in women with fibromyalgia and relationship between pain, tender point count and disease activity. Acta Med Medi- terr 2016; 32:243-7.
7. Dogru A, Balkarli A, Cobankara V, Tunc SE, Sahin M. Effects of vitamin D therapy on quality of life in patients with fibromyalgia. Eurasian J Med 2017; 49(2):113-7.
8. Altındağ O, Öğüt E, Gur A, Gursoy S, Gunay M. Serum vitamin D level and its relation with clinical parameters in fibromyalgia as a neuropathic pain. Orthop Muscular Syst 2014; 3:171.

9. Gendelman O, Itzhaki D, Makarov S, Bennun M, Ami- tal H. A randomized double-blind placebo-controlled study adding high dose vitamin D to analgesic regimens in patients with musculoskeletal pain. Lupus 2015; 24(4- 5):483-9.
10. Andersen ML, Tufik S. Vitamin D as an underlying factor in sleep-related issues. J Clin Sleep Med 2012; 8(6):699.
11. McCarty DE, Reddy A, Keigley Q, Kim PY, Cohen S, Marino AA. Nonspecific pain is a marker for hypovita- minosis D in patients undergoing evaluation for sleep dis- orders: a pilot study. Nat Sci Sleep 2013; 5:37-42.
12. Eyles DW, Liu PY, Josh P, Cui X. Intracellular distribu- tion of the vitamin D receptor in the brain: Comparison with classic target tissues and redistribution with develop- ment. Neuroscience 2014; 268:1-9.
13. Ulusoy H, Sarica N, Arslan S, Ozyurt H, Cetin I, Birgul Ozer E, Yildirim N. Serum vitamin D status and bone mineral density in fibromyalgia. Bratisl Lek Listy 2010; 111:604-9
14. Okumus M, Koybası M, Tuncay F, Ceceli E, Ayhan F, Yorgancioglu R, Borman P. Fibromyalgia syndrome: Is it related to vitamin D deficiency in premenopausal female patients? Pain Manag Nurs 2013; 14(4):156-63.
15. Ediz L, Hiz O, Toprak M, Tekeoglu I, Ercan S. The validity and reliability of the Turkish version of the revised fibromyalgia impact questionnaire. Clin Rheumatol 2011; 30:339-46.
16. Koçyiğit H, Aydemir Ö, Fişek G, Ölmez N, Memiş A. Reliability and validity of the Turkish version of short form-36 (SF-36): A study in a group of patients will rheu- matic diseases. Turk J Drugs Ther 1999; 12:102-6.
17. Hisli N. Beck depression inventory for university students validity and reliability. Turk J Psychol 1989; 7:3-13
18. Ağargün MY, Kara H, Anlar O. The Validity and Reli- ability of the Pittsburgh Sleep Quality Index. Turk J Psy- chiatry 1996; 7(2):107-11.
19. İzci B, Ardıç S, Fırat H, Şahin A, Altınörs M. Reliability and validity studies of the Turkish version of the epworth sleepiness scale. Sleep Breath 2008; 12(2):161-8.
20. Soykan A. The reliability and validity of Arizona sexual experiences scale in Turkish ESRD patients undergoing hemodialysis. Int J Impot Res 2004; 16:531-4.
21. Martins YA, Cardinali CAEF, Ravanelli MI, Brunaldi K. Is hypovitaminosis D associated with fibromyalgia? A systematic review. Nutr Rev 2020; 78(2):115-33. (Epub ahead of print).
22. Amin OA, Abouzeid SM, Ali SA, Amin BA, Alswat KA. Clinical association of vitamin D and serotonin levels among patients with fibromyalgia syndrome. Neuropsy- chiatr Dis Treat 2019; 15:1421-1426
23. Makrani AH, Afshari M, Ghajar M, Forooghi Z, Moo- sazadeh M. Vitamin D and fibromyalgia: A meta-analy- sis. Korean J Pain 2017; 30(4):250-7.
24. Olama SM, Senna MK, Elarman MM, Elhawary G. Serum vitamin D level and bone mineral density in pre- menopausal Egyptian women with fibromyalgia. Rheu- matol Int 2013; 33(1):185-92.
25. Yilmaz R, Salli A, Cingoz HT, Kucuksen S, Ugurlu H. Efficacy of vitamin D replacement therapy on patients with chronic nonspecific widespread musculoskeletal pain with vitamin D deficiency. Int J Rheum Dis 2016; 19(12):1255-62.
26. Maafi AA, Ghavidel-Parsa B, Hangdoost A. Serum Vita- min D status in Iranian fibromyalgia patients: According to the symptom severity and illness invalidation. Korean J Pain 2016; 29(3):172-8.
27. Lİge-Hagen JS, Sæle A, Juhl C, Bech P, Stenager E, Mellentin AI. Prevalence of depressive disorder among patients with fibromyalgia: Systematic review and meta-analysis. J Affect Disord 2019; 245:1098-105.
28. Del Pozo-Cruz J, Alfonso-Rosa RM, Castillo-Cuerva A, Sañudo B, Nolan P. Depression symptoms are associated with key health outcomes in women with fibromyalgia: A cross-sectional study. Int J Rheum Dis 2017; 20(7):798- 808.
29. Collado-Mateo D, Olivares PR, Adsuar JC, Gusi N. Impact of fibromyalgia on sexual function in women. J Back Musculoskelet Rehabil 2020; 33(3):355-61. (Epub ahead of print).
30. Krysiak R, Gilowska M, Okopień B. Sexual function and depressive symptoms in young women with low vitamin D status: A pilot study. Eur J Obstet Gynecol Reprod Biol 2016; 204:108-12.