Relationship Of Breast Cancer And Molecular Subtypes With Menopausal Status And Body Mass Index

Abstract

Relationship Of Breast Cancer And Molecular Subtypes With Menopausal Status And Body Mass Index ABSTRACT Objectives: To determine the relationship between body mass index (BMI) and breast cancer subtypes according to menopausal status. Methods: Medical records of 802 patients who were followed up with the diagnosis of breast cancer in XXX Training and Research Hospital were retrospectively reviewed. The patients were divided into two groups according to menopausal status as premenopausal and postmenopausal. The groups were further categorized into subgroups as normal weight, overweight, and obese according to the BMI. For breast cancer subtype analysis, the St. Gallen classification was used. The effect of BMI on breast cancer subtypes according to menopausal status was analyzed. Results: Of the 802 patients, 44.8% (n=359) were premenopausal and 55.2% (n=443) were postmenopausal. When the patients were categorized according to the BMI, the rate of overweight and obese patients in the premenopausal group was 60.1% while this value was 82.1% in the postmenopausal group. It was observed that the number of overweight and obese patients was statistically significantly higher in the postmenopausal group. However, no statistically significant correlation was found in the analyses performed between BMI and breast cancer immunohistochemical subtypes in either group. Conclusions: The findings of this study support that obesity causes an increased risk of breast cancer in the postmenopausal period, independent of breast cancer immunohistochemical subtypes. The relationship between obesity and breast cancer should be evaluated together with risk factors, such as family history, ethnicity, and use of hormone replacement therapy since their roles have been more clearly defined in the etiology of breast cancer than obesity. Key Words: Body mass index, Breast cancer, Menopausal status, Molecular subtypes

Keywords

• Body mass index
• Breast cancer
• Menopausal status
• Molecular subtypes

Meme Kanseri ve Moleküler Alt Tiplerinin Menopoz Durumu ve Vücut Kitle İndeksi İle İlişkisi

Öz

ÖZ Amaç: Bu çalışmanın amacı vücut kitle indeksinin menopozal duruma göre meme kanseri subtipleri ile olan ilişkisinin belirlenmesidir. Yöntem: Sağlık Bilimleri Üniversitesi, XXX Eğitim ve Araştırma Hastanesinde meme kanseri tanısı ile takip edilen 802 hastanın dosyaları geriye dönük tarandı ve demografik, klinik ve patolojik karakteristikleri kaydedildi. Hastalar, menopozal duruma göre premenopozal ve postmenopozal olmak üzere iki gruba ayrıldı. Gruplar vücut kitle indeksi verilerine göre normal kilolu, aşırı kilolu ve obez olarak alt gruplara kategorize edildi. Meme kanseri subtip analizi için St. Gallen klasifikasyonu kullanıldı. Menopozal duruma göre vücut kitle indeksinin meme kanseri subtipleri üzerindeki etkisi analiz edildi. Bulgular: 802 hastanın %44,8’i (n: 359) premenopozal, %55,2’si (n: 443) ise postmenopozal idi. Hastalar vücut kitle indeksi verilerine göre kategorize edildiğinde premenopozal grupta aşırı kilolu ve obez hasta oranı %60,1 olup bu değer postmenopozal grupta %82,1 olarak izlendi. Aşırı kilolu ve obez hasta sayısının postmenopozal grupta istatistiksel olarak anlamlı şekilde daha fazla olduğu izlendi. Ne premenopozal ne de postmenopozal grupta vücut kitle indeksi ile meme kanseri immünhistokimyasal subtipleri arasında yapılan analizlerde istatistiksel olarak anlamlı bir korelasyon izlenmedi. Sonuçlar: Bu çalışmanın bulguları, obezitenin meme kanseri immünhistokimyasal subtiplerinden bağımsız olarak postmenopozal dönemde meme kanseri riskinde artışa neden olduğunu desteklemektedir. Obezite ve meme kanseri ilişkisi, meme kanseri etyolojisindeki rolleri obeziteye göre daha net olarak belirlenmiş olan aile öyküsü, etnisite ve hormon replasman tedavisi kullanımı gibi risk faktörleriyle birlikte değerlendirilmelidir. Anahtar Sözcükler: Vücut kitle indeksi, Meme kanseri, Menopozal durum, Moleküler subtipler

Anahtar Kelimeler

• Vücut kitle indeksi
• Meme kanseri
• Menopozal durum
• Moleküler subtipler

Kaynakça

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