Evaluation of Childhood Surrenal Regional Masses: A Single Center Experience

Öz

Aim: Adrenal masses are rare in childhood, but when detected, close follow-up is mandatory. Childhood age cells adrenal masses usually require surgical intervention. Its epidemiology is well known. Although neoplastic masses are frequently seen, routine imaging at an early age shows that adrenal hemorrhages are not uncommon (1). In this study, it was aimed to evaluate the etiology, follow-up and treatment processes of adrenal region masses referred to the pediatric endocrine clinic. Method: Our study is a single-center, retrospective study examining patients admitted between 2021-2023. In our study, 17 patients aged 0-18 years, who were referred to the pediatric endocrine clinic and diagnosed with adrenal region masses, were retrospectively analyzed. Results: 53.5% of the cases were hematoma (n=9), 11.7% were neuroblastoma (2), 5.8% were pheochromocytoma (n=1), 5.8% were paraganglioma (n=1) , 5.8% got simple cyst (n=1), 5.8% got cortical functional adenoma (n=1). Two (11.7%) organs were absent in pathological examinations, but they were asymptomatic, shrinking masses. Three patients who underwent hematoma examination were treated for adrenal insufficiency. Heterozygous, possibly pathogenic, c.649C>G (p.Arg217Gly) predictor was detected in the SDHB (succinate dehydrogenase subunit B) gene analyzed from the tumor that received a paraganglioma case and from peripheral blood. Conclusion: In our study, we showed that the adrenal region masses observed in endocrine clinics have various etiologies.

Anahtar Kelimeler

• childhood
• mass
• surrenal

Çocukluk Çağı Sürrenal Bölge Kitlelerinin Değerlendirilmesi: Tek Merkez Deneyimi

Öz

Amaç: Çocukluk çağında sürrenal kitleler nadirdir ancak saptandığında yakın takip gerektirmektedir. Çocukluk yaş grubunda sürrenal kitleler genellikle cerrahi girişim gerektirir. Epidemiyolojisi tam olarak bilinmemektedir. Sıklıkla neoplastik kitleler görülmekle birlikte erken yaşta yapılan rutin görüntülemeler adrenal hemorajilerin de nadir olmadığını göstermektedir (1). Bu çalışmada çocuk endokrin kliniği ile refere edilen sürrenal bölge kitlelerinin etyoloji, takip ve tedavi süreçlerinin değerlendirilmesi amaçlandı. Yöntem: Çalışmamız 2021-2023 yılları arasında başvuran hastaların incelendiği, tek merkezli, retrospektif bir çalışmadır. Çalışmamızda çocuk endokrin kliniğine refere edilen, sürrenal bölge kitlesi tespit edilen 0-18 yaş aralığındaki 17 hasta retrospektif olarak incelendi. Bulgular: Olguların %53,5’i hematom (n=9), %11,7’si nöroblastom (2), %5,8’i feokoromasitoma (n=1), %5,8’i paraganglioma (n=1), %5,8’i basit kist (n=1), %5,8’i kortikal fonksiyonel adenom tanısı aldı (n=1). İki (%11,7) hastanın patolojik tanısı yoktu ancak bulgu vermeyen, zamanla küçülen kitlelerdi. Hematom tanısı alan 3 hasta adrenal yetmezlik nedeniyle tedavi aldı. Paraganglioma tanısı alan hastanın tümörden ve periferik kandan bakılan SDHB (succinate dehydrogenase subunit B) geninde heterozigot, muhtemel patojenik, c.649C>G (p.Arg217Gly) varyant tespit edildi. Sonuç: Çalışmamızda endokrin kliniklerinde izlenen sürrenal bölge kitlelerinin oldukça çeşitli etyolojilerde olduğunu göstermiş olduk.

Anahtar Kelimeler

• çocukluk çağı
• kitle
• sürrenal

Kaynakça

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