Çocuklarda Apendisit Tanısında Lenfosit Monosit Oranı Değerinin Rolü

Öz

Amaç: Apendisit, çocuk yaş grubunda sağ alt kadran ağrısının en sık cerrahi hastalığıdır. Bu çalışmanın amacı, çocuklarda apendisitte lenfosit monosit oranının(LMO) tanısal değerini araştırmaktır. Yöntemler: 2017-2020 yılları arasında 18 yaşından küçük inflamatuar olmayan nedenlerle hastaneye başvurup kanları alınan ve apendisit (komplike olmayan veya komplike olmayan) tanısı almış toplam 150 hasta retrospektif olarak incelendi. Hastalar Grup 1 (inflamasyonu olmayan sağlıklı çocuklar, n=50), Grup 2 (komplike olmayan apendisit, n=50) ve Grup 3 (komplike apendisit, n=50) olmak üzere üç alt gruba ayrıldı. Bulgular: Ortalama LMO düzeyinin komplike olmayan ve komplike apendisit gruplarında grup 1'e göre anlamlı olarak düşük olduğu görüldü(p=0,000). LMO'nun komplike olmayan apandisiti öngörmek için başvurudaki cut-off değeri 2,98'dir, duyarlılığı %94 ve özgüllüğü %96'dır (eğrinin altındaki alan, 0,960, p= 0,000). LMR'nin başvuruda komplike apandisiti öngörmek için cut-off değeri 2,15, duyarlılığı %96 ve özgüllüğü %72 idi (eğri altındaki alan, 0,865, p= 0,000). Sonuç: Bu çalışma, LMO oranının yüksek duyarlılık ve özgüllük ile apandisit tanısının koyulmasında yardımcı olabileceğini göstermektedir.

Anahtar Kelimeler

• Apandisit
• Çocuk
• inflamasyon
• lenfosit monosit oranı

The Role of Lymphocyte-to-Monocyte Ratio Levels in Diagnosis of Appendicitis in Children

Öz

Objective: Appendicitis is the most common surgical disease with right lower abdominal pain in pediatric age. This study aimed to investigate the diagnostic value of lymphocyte monocyte ratio (LMR) in appendicitis in children. Methods: A total of 150 patients under the age of 18 who were admitted hospital and given blood samples due to reasons of non-inflammatory conditions and were proved to have appendicitis (non-complicated or complicated) between 2017-2020 were analyzed retrospectively. Patients were classified into three subgroups: Group 1 (healthy children without any inflammation, n=50), Group 2 (non-complicated appendicitis, n=50) and Group 3 (complicated appendicitis, n=50). Results: The median LMR level was significantly lower in the non-complicated and complicated appendicitis groups than in group 1 (p=0,000). The cut-off value of LMR on admission to predict non-complicated appendicitis was 2,98 with a sensitivity of 94% and a specificity of 96% (area under the curve, 0,960, p= 0,000). The cut-off value of LMR on admission to predict complicated appendicitis was 2,15 with a sensitivity of 96% and a specificity of 72% (area under the curve, 0,865, p= 0,000). Conclusion: This study shows that LMR ratio may be helpful with high sensitivity and specificity in diagnosing appendicitis.

Anahtar Kelimeler

• Appendicitis
• Children
• inflammation
• lymphocyte monocytes ratio

Kaynakça

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