Pulmoner Aspergillozisin Klinik Tipleri: Bir Klinik Spektrum Derlemesi

Öz

Aspergillus mantar türleri doğada bulunur ve insanlarda pulmoner aspergilloz hastalıklarının nedenidir. Klinik ve radyolojik olarak genel olarak dört formda görülür; bunlar aspergilloma, kronik pulmoner aspergilloz, invaziv pulmoner aspergillozis ve allerjik bronkopulmoner aspergillozistir. Ancak pulmoner aspergillus türlerinin bir arada görüldüğü örtüşme sendromları da gözden kaçırılmamalıdır. Klinik semptomlar, radyolojik görüntüleme, serum antijen ve antikor düzeyleri, vücut sıvısı kültürleri, hızlı deri antijen testleri, serum immunoglobulin düzeyleri tanıya yardımcıdır. Tedavi seçenekleri vaka bazında değerlendirilse de; antifungal tedavi, cerrahi ve kortikosteroid ajanlar ana seçeneklerdir. COVİD-19 ile ilişkili invaziv pulmoner aspergillozis, COVİD-19 enfeksiyonu ile tanımlanmıştır. Kötü klinik prognoz nedeniyle COVİD-19 hastalarında gözden kaçırılmamalıdır.

Anahtar Kelimeler

• aspergillozis
• göğüs cerrahisi
• covid-19
• tedavi

Clinical Types of Pulmonary Aspergillosis: A Clinical Spectrum Review

Abstract

Aspergillus fungal species are found in nature and are the cause of pulmonary aspergillosis diseases in humans. It is generally seen in four forms clinically and radiologically, these are aspergilloma, chronic pulmonary aspergillosis, invasive pulmonary aspergillosis and allergic bronchopulmonary aspergillosis. However, overlap syndromes in which types of pulmonary aspergillosis are seen together should not be overlooked. Clinical symptoms, radiological imaging, serum antigen and antibody levels, body fluid cultures, rapid skin antigen tests, serum immunoglobulin levels are helpful for diagnosis. Although treatment options are evaluated on a case-by-case basis; antifungal therapy, surgery and corticosteroid agents are the main options. Invasive pulmonary aspergillosis associated with COVID-19 has been observed in association with COVID-19 infection. It should not be missed in patients with COVID-19 due to poor clinical prognosis.

Keywords

• aspergillosis
• thoracic surgery
• covid-19
• treatment

Kaynakça

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