Düşük Nikel Diyetinin Hastalıklarda Kullanımı

Öz

Nikel, çevrede yaygın olarak bulunan bir metal olup, özellikle duyarlı bireylerde dermatolojik ve sistemik reaksiyonlara yol açabilmektedir. Nikel alerjisi ve buna bağlı gelişen alerjik kontakt dermatit, günümüzde hem toplumda hem de mesleki maruziyetin yoğun olduğu gruplarda önemli bir sağlık sorunu oluşturmaktadır. Besinlerle alınan nikelin, yalnızca cilt reaksiyonlarına değil; aynı zamanda endometriozis, irritabl bağırsak sendromu, Crohn hastalığı, gastroözofageal reflü hastalığı, çölyak hastalığı ve laktoz intoleransı gibi birçok hastalığın semptomlarını tetikleyebileceği bildirilmiştir. Düşük nikel diyeti, bu tür klinik durumlarda nikel maruziyetini azaltarak semptomların hafifletilmesinde destekleyici bir yaklaşım olarak öne çıkmaktadır. Bu derleme, nikelin biyolojik ve toksikolojik özellikleri ile birlikte, düşük nikel diyetinin söz konusu hastalıklardaki etkilerini güncel literatür doğrultusunda değerlendirmeyi amaçlamaktadır. Bulgular, düşük nikel diyetinin hem dermatolojik hem de gastrointestinal belirtilerin kontrolünde etkili olabileceğini göstermektedir. Ancak bu ilişkinin daha net anlaşılabilmesi için ileri düzey randomize kontrollü çalışmalara ihtiyaç duyulmaktadır.

Anahtar Kelimeler

• Düşük Nikel diyeti
• Nikel alerjisi
• Dermatit
• Endometriozis
• Çölyak Hastalığı

The Use of Low Nickel Diet in Diseases

Öz

Nickel is a widely distributed metal in the environment and can lead to dermatological and systemic reactions, particularly in sensitive individuals. Nickel allergy and the associated allergic contact dermatitis are significant public health concerns, both in the general population and among individuals with high occupational exposure. Dietary intake of nickel has been reported to trigger not only cutaneous reactions but also the symptoms of several other conditions such as endometriosis, irritable bowel syndrome, Crohn's disease, gastroesophageal reflux disease, celiac disease, and lactose intolerance. The low-nickel diet emerges as a supportive nutritional approach for reducing nickel exposure and alleviating symptoms in such clinical situations. This review aims to evaluate the biological and toxicological properties of nickel, as well as the potential benefits of a low-nickel diet for managing these conditions, based on the current literature. Findings suggest that a low-nickel diet may be effective in controlling both dermatological and gastrointestinal symptoms. However, further randomized controlled trials are needed to better understand this relationship.

Anahtar Kelimeler

• Low Nickel diet
• Nickel allergy
• Dermatitis
• Endometriosis
• Celiac Disease

Kaynakça

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