Romatoid Artritte Plazma sTRAIL Düzeyi ile Hastalık Aktivitesi İlişkisi

Yıl 2017, Cilt: 3 Sayı: 2, 95 - 100, 01.01.2017

Funda Erbasan Veli Yazısız Münevver Kahraman Ender Terzioğlu

Öz

Amaç: Çalışmanın amacı romatoid artritte plazmada çözünmüş TNF ilişkili apoptoz tetikleyici ligand sTRAIL düzeyinin saptanması ve sTRAIL düzeyinin hastalık aktivitesi ile ilişkisinin araştırılmasıdır. Gereç ve Yöntemler: 19 Romatoid artrit RA hastası ve kontrol grubu olarak belirlenen 31 primer Sjögren sendromu pSS hastası ile 24 sağlıklı kişi çalışmaya dahil edildi. RA hastalarının hastalık aktivitesi, hastalık aktivite skoru-28 DAS-28 ile hesaplandı. Plazma sTRAIL düzeyi immunoenzimatik yöntem ELISA ile ölçüldü. Bulgular: Ortalama sTRAIL düzeyi RA hastalarında 1751 ± 635 pg/ml , pSS hastaları 1234 ± 625 pg/ml ve sağlıklı kontrol 1181 ± 304 pg/ml grubundan daha yüksek olarak ölçüldü p=0.002 . RA hastalarında DAS-28 ve sTRAIL düzeyi arasında bir korelasyon saptanmadı. Ayrıca sTRAIL düzeyi ile hastalık aktivitesini gösteren ESR ve CRP arasında da korelasyon saptanmadı. Sonuç: RA’li hastaların sTRAIL düzeyleri hastalık aktivitesinden bağımsız olarak anlamlı düzeyde artmaktadır. Bu bulgular sTRAIL’in RA patogenezinde önemli bir rol alabileceğini göstermektedir

Anahtar Kelimeler

TNF ilişkili apoptoz tetikleyici ligand, Romatoid artrit, Sjögren sendromu

The Relationship Between Plasma sTRAIL Level and Disease Activity in Rheumatoid Arthritis

Öz

Objective: The purpose of this study was to investigate the plasma soluble tumour necrosis factor related apoptosis-inducing ligand sTRAIL level in rheumatoid arthritis RA and to evaluate the relationship between sTRAIL and disease activity. Material and Methods: 19 RA patients, and as a control group 31 primary Sjogren’s syndrome pSS patients and 24 healthy subjects were included in the study. Disease activity of RA patients was calculated by the Disease Activity Score-28 DAS-28 . Plasma sTRAIL concentrations were measured by the enzyme linked immunosorbent assay ELISA .Results: Mean plasma sTRAIL concentration in RA patients 1751 ± 635 pg/ml was higher than in disease control patients with pSS 1234 ± 625 pg/ml and in healthy controls 1181 ± 304 pg/ml p=0.002 . In RA patients, there was no correlation between mean DAS-28 score and plasma sTRAIL levels. And also, there was no correlation between sTRAIL levels and laboratory parameters indicating disease activity such as the erythrocyte sedimentation rate ESR and C-reactive protein CRP . conclusion: Plasma sTRAIL levels were significantly higher in RA regardless of disease activity. These findings suggest that sTRAIL may have an important role in the pathogenesis of rheumatoid arthritis

Anahtar Kelimeler

TNF-related apoptosis inducing ligand, Rheumatoid arthritis, Sjogren’s syndrome

Kaynakça

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