Obez Prepubertal Çocuklarda Ortalama Trombosit Hacmi

Yıl 2018, Cilt: 4 Sayı: 1, 54 - 59, 01.01.2018

Hamdi Cihan Emeksiz

Öz

Amaç: Bir trombosit aktivasyon belirteci olan ortalama trombosit hacmi OTH , erişkinlerde, obezite ve kardiyovasküler hastalıklar ile ilişkili bulunmuştur. Ancak çocukluk yaş grubunda OTH ile obezite arasındaki ilişkiyi inceleyen az sayıda çalışma mevcuttur. Bu kesitsel çalışmanın amacı; obez prepubertal çocukların OTH değerleri ile sağlıklı kontrollerin OTH değerlerini karşılaştırmaktır. Gereç ve Yöntemler: Çocuk endokrin polikliniğinde obezite tanısı almış, yaşları 6-10,5 yıl arasında değişen 51 prepubertal çocuk ve çocuk endokrin polikliniğine genel kontrol amacıyla başvurmuş sağlıklı ve normal tartılı 46 prepubertal çocuk çalışmaya dahil edilmiştir. Bulgular: Trombosit sayısı, OTH ve trombosit dağılım genişliği TDG parametrelerinde, hasta ve kontrol grupları arasında istatistiksel olarak anlamlı fark bulunmadı p>0,05 . Bu üç parametre ile; vücut kütle indeksi, bel çevresi, kalça çevresi, kan şekeri, insülin, tiroid fonksiyon testleri, karaciğer fonksiyon testleri ve lipid profi li arasında herhangi bir korelasyon saptanmadı p>0,05 . Sonuç: Ortalama trombosit hacmi çocukluk yaş grubunda obezite ile ilişkili gözükmemektedir. Bu sonucun desteklenmesi için çocuklarda yapılacak daha geniş örneklemli prospektif çalışmalara ihtiyaç vardır

Anahtar Kelimeler

Ortalama trombosit hacmi, Obezite, Çocuk

Mean Platelet Volume in Obese Prepubertal Children

Öz

Objective: Mean platelet volume MPV , a marker of platelet activation, has been found to be associated with obesity and cardiovascular diseases in adults. However, only a few studies thus far have investigated the relationship between MPV and obesity during childhood. The aim of this crosssectional study was to compare the MPV values of obese prepubertal children with those of healthy controls.Material and Methods: Fifty-one prepubertal children aged 6 to 10.5 years diagnosed with obesity at the pediatric endocrinology clinic and 46 healthy prepubertal children with normal weight were enrolled in this study. Results: Platelet count, MPV and platelet distribution width PDW did not differ signifi cantly between the patient and control groups p>0.05 . There was no correlation between any of these three parameters and the body mass index, waist circumference, hip circumference, blood sugar, insulin, thyroid function tests, liver function tests and lipid profi le p>0.05 . Conclusion: Mean platelet volume does not seem to be associated with obesity in children. There is a need for large scale prospective studies in the pediatric age group to support this finding

Anahtar Kelimeler

Mean platelet volume, Obesity, Child

Kaynakça

• 1. Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, Mullany EC, Biryukov S, Abbafati C, Abera SF, Abraham JP, Abu-Rmeileh NM, Achoki T, AlBuhairan FS, Alemu ZA, Alfonso R, Ali MK, Ali R, Guzman NA, Ammar W, Anwari P, Banerjee A, Barquera S, Basu S, Bennett DA, Bhutta Z, Blore J, Cabral N, Nonato IC, Chang JC, Chowdhury R, Courville KJ, Criqui MH, Cundiff DK, Dabhadkar KC, Dandona L, Davis A, Dayama A, Dharmaratne SD, Ding EL, Durrani AM, Esteghamati A, Farzadfar F, Fay DF, Feigin VL, Flaxman A, Forouzanfar MH, Goto A, Green MA, Gupta R, Hafezi-Nejad N, Hankey GJ, Harewood HC, Havmoeller R, Hay S, Hernandez L, Husseini A, Idrisov BT, Ikeda N, Islami F, Jahangir E, Jassal SK, Jee SH, Jeffreys M, Jonas JB, Kabagambe EK, Khalifa SE, Kengne AP, Khader YS, Khang YH, Kim D, Kimokoti RW, Kinge JM, Kokubo Y, Kosen S, Kwan G, Lai T, Leinsalu M, Li Y, Liang X, Liu S, Logroscino G, Lotufo PA, Lu Y, Ma J, Mainoo NK, Mensah GA, Merriman TR, Mokdad AH, Moschandreas J, Naghavi M, Naheed A, Nand D,Narayan KM, Nelson EL, Neuhouser ML, Nisar MI, Ohkubo T, Oti SO, Pedroza A, Prabhakaran D, Roy N, Sampson U, Seo H, Sepanlou SG, Shibuya K, Shiri R, Shiue I, Singh GM, Singh JA, Skirbekk V, Stapelberg NJ, Sturua L, Sykes BL, Tobias M, Tran BX, Trasande L, Toyoshima H, van de Vijver S, Vasankari TJ, Veerman JL, Velasquez-Melendez G, Vlassov VV, Vollset SE, Vos T, Wang C, Wang X, Weiderpass E, Werdecker A, Wright JL, Yang YC, Yatsuya H, Yoon J, Yoon SJ, Zhao Y, Zhou M, Zhu S, Lopez AD, Murray CJ, Gakidou E. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014; 384(9945): 766-81.
• 2. TC Sağlık Bakanlığı. Türkiye’de Okul Çağı Çocuklarında (6-10 Yaş Grubu) Büyümenin İzlenmesi (TOÇBİ) Projesi Araştırma Raporu. Ankara: 2011.
• 3. Deshmukh-Taskar P, Nicklas TA, Morales M, Yang SJ, Zakeri I, Berenson GS. Tracking of overweight status from childhood to young adulthood: The Bogalusa Heart Study. Eur J Clin Nutr 2006; 60: 48–57.
• 4. Goff DC Jr, Lloyd-Jones DM, Bennett G, Coady S, D’Agostino RB, Gibbons R, Greenland P, Lackland DT, Levy D, O’Donnell CJ, Robinson JG, Schwartz JS, Shero ST, Smith SC Jr, Sorlie P, Stone NJ, Wilson PW, Jordan HS, Nevo L, Wnek J, Anderson JL, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH, DeMets D, Hochman JS, Kovacs RJ, Ohman EM, Pressler SJ, Sellke FW, Shen WK, Smith SC Jr, Tomaselli GF; American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014; 129 (25): S49-73.
• 5. Gawaz M, Langer H, May AE. Platelets in infl ammation and atherogenesis. J Clin Invest 2005;115: 3378-84.
• 6. Renga B, Scavizzi F. Platelets and cardiovascular risk. Acta Cardiol 2017; 72(1): 2-8.
• 7. Tsiara S, Elisaf M, Jagroop IA, Mikhailidis DP. Platelets as predictors of vascular risk: Is there a practical index of platelet activity? Clin Appl Thromb Hemost 2003; 9: 177- 90.
• 8. Coban E, Ozdogan M, Yazicioglu G, Akcit F. The mean platelet volume in patients with obesity. Int J Clin Pract 2005;59:981-2.
• 9. Coban E, Yilmaz A, Sari R. The effect of weight loss on the mean platelet volume in obese patients. Platelets 2007;18(3):212-6.
• 10. Muscari A, De Pascalis S, Cenni A, Ludovico C, Castaldini N, Antonelli S, Bianchi G, Magalotti D, Zoli M. Determinants of mean platelet volume (MPV) in an elderly population: Relevance of body fat, blood glucose and ischaemic electrocardiographic changes. Thromb Haemost 2008; 99(6): 1079-84.
• 11. Yüksel Kalkan G, Gür M, Baykan AO, Uçar H, Elbasan Z, Şahin DY, Koç M, Börekçi, A, Çaylı M. Mean platelet volume is associated with aortic intima-media thickness in patients without clinical manifestation of atherosclerotic cardiovascular disease. Anatol J Cardiol 2015 ;15(9):753- 8.
• 12. Arslan N, Makay B. Mean platelet volume in obese adolescents with nonalcoholic fatty liver disease. J Pediatr Endocrinol Metab 2010 ;23(8): 807-13.
• 13. Arslan N, Makay B, Hızlı S, Koçyiğit A, Demircioğlu F, Tuncel AS, Cakmakçı H. Assessment of atherosclerosis in obese adolescents: Positive correlation of mean platelet volume and carotid intima media thickness. J Paediatr Child Health 2013; 49(11): 963-8.
• 14. Özkan EA, Khosroshahi HE, Serin Hİ, Özdemir ZT, Kılıç M, Ekim M, Geçit UA, Domur E. The evaluation of carotid intima-media thickness and mean platelet volume values and correlation with cardiac functions in obese children. Int J Clin Exp Med 2015; 8(12): 22557-63.
• 15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta−cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412–19.
• 16. Mallika V, Goswami B, Rajappa M. Atherosclerosis pathophysiology and the role of novel risk factors: A clinicobiochemical perspective. Angiology 2007; 58(5): 513-22.
• 17. Ford ES; National Health and Nutrition Examination Survey. C-reactive protein concentration and cardiovascular disease risk factors in children: fi ndings from the National Health and Nutrition Examination Survey 1999- 2000. Circulation 2003; 108(9): 1053-8.
• 18. Kullo IJ, Ballantyne CM. Conditional risk factors for atherosclerosis. Mayo Clin Proc 2005; 80(2): 219-30.
• 19. Papanas N, Symeonidis G, Maltezos E, Mavridis G, Karavageli E, Vosnakidis T, Lakasas G. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets 2004; 15: 475-8.
• 20. Nadar S, Blann AD, Lip GY. Platelet morphology and plasma indices of platelet activation in essential hypertension: effects of amlodipine-based antihypertensive therapy. Ann Med 2004; 36: 552-7.