Derleme
BibTex RIS Kaynak Göster

Psikiyatrik Boyutlarıyla Dürtüsellik

Yıl 2025, Cilt: 34 Sayı: 3, 195 - 208, 30.09.2025
https://doi.org/10.17827/aktd.1698682

Öz

Bu derleme, dürtüsellik kavramının psikiyatrik boyutlarını çok yönlü olarak incelemektedir. Dürtüsellik; plansız ve hızlı hareket etme, risk alma, ödül arayışı gibi davranış örüntüleriyle tanımlanır ve birçok psikiyatrik bozukluğun temel belirtileri arasında yer almaktadır. Bireylerin yaklaşık %11’inde dürtüsel davranış örüntüleri klinik düzeyde gözlenmektedir. Dürtüsellik, dikkat eksikliği ve hiperaktivite bozukluğu (DEHB) olgularının %70’inden fazlasında görülmekte ve bu bireylerde akademik ve sosyal işlevselliği önemli ölçüde etkilemektedir. Nörobiyolojik düzeyde prefrontal ve orbitofrontal korteks gibi beyin bölgeleri ile serotonin, dopamin ve noradrenalin sistemlerinin dürtüsellikte belirleyici olduğu gösterilmiştir. Cinsiyet farklılıkları ve hormonal etkiler dürtüsel davranışların ortaya çıkışında önemli bir role sahiptir. Dürtüsellik; DEHB, kişilik bozuklukları, duygudurum bozuklukları ve madde kullanım bozuklukları gibi birçok psikiyatrik bozuklukta önemli bir belirti olarak ön plana çıkmaktadır. Değerlendirmelerde öz bildirim ölçekleri, davranışsal testler ve biyolojik ölçümler birlikte kullanılmaktadır. Sonuç olarak, dürtüsellik çok boyutlu ve kompleks bir davranış örüntüsü olup, psikiyatrik bozuklukların anlaşılmasında önemli bir yere sahiptir. Bu alanda yapılacak ileri araştırmalar, dürtüselliğin biyolojik temellerinin ve psikiyatrik bozukluklardaki rolünün daha iyi anlaşılmasına katkı sağlayacak, tedavi yaklaşımlarının iyileştirilmesi açısından büyük önem taşıyacaktır.

Kaynakça

  • 1. Moore FR, Doughty H, Neumann T, McClelland H, Allott C, O’Connor RC. Impulsivity, aggression, and suicidality relationship in adults: a systematic review and meta-analysis. EClinicalMedicine. 2022;45.
  • 2. American Psychiatric Association. DSM-5 Diagnostic Classification. In: Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association, 2013.
  • 3. Nigg JT. Annual Research Review: On the relations among self‐regulation, self‐control, executive functioning, effortful control, cognitive control, impulsivity, risk‐taking, and inhibition for developmental psychopathology. Journal of child psychology and psychiatry. 2017;58(4):361-383.
  • 4. Eysenck SBG, Eysenck HJ. The place of impulsiveness in a dimensional system of personality description. British Journal of Social and Clinical Psychology. 1977;16(1):57-68.
  • 5. Patton JH, Stanford MS, Barratt ES. Factor structure of the Barratt impulsiveness scale. J Clin Psychol. 1995;51(6):768-774.
  • 6. Ainslie G. Specious reward: a behavioral theory of impulsiveness and impulse control. Psychol Bull. 1975;82(4):463.
  • 7. Hollander E, Evers M. New developments in impulsivity. The Lancet. 2001;358(9286):949-950.
  • 8. Moeller FG, Barratt ES, Dougherty DM, Schmitz JM, Swann AC. Psychiatric aspects of impulsivity. American journal of psychiatry. 2001;158(11):1783-1793.
  • 9. Stahl C, Voss A, Schmitz F, et al. Behavioral components of impulsivity. J Exp Psychol Gen. 2014;143(2):850.
  • 10. Cross CP, Copping LT, Campbell A. Sex differences in impulsivity: a meta-analysis. Psychol Bull. 2011;137(1):97.
  • 11. Huang Y, Luan S, Wu B, et al. Impulsivity is a stable, measurable, and predictive psychological trait. Proceedings of the National Academy of Sciences. 2024;121(24):e2321758121.
  • 12. L’Abate L. A family theory of impulsivity. In: The impulsive client: Theory, research, and treatment. 1st ed. Ed(s): McCown WG, Johnson JL, Shure MB: 93–117. Washington, DC, American Psychological Association, 1993.
  • 13. Barratt ES, Stanford MS, Kent TA, Alan F. Neuropsychological and cognitive psychophysiological substrates of impulsive aggression. Biol Psychiatry. 1997;41(10):1045-1061.
  • 14. Linnoila M, Virkkunen M, Scheinin M, Nuutila A, Rimon R, Goodwin FK. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sci. 1983;33(26):2609-2614.
  • 15. Barratt ES, Stanford MS, Felthous AR, Kent TA. The effects of phenytoin on impulsive and premeditated aggression: a controlled study. J Clin Psychopharmacol. 1997;17(5):341-349.
  • 16. Raji H, Dinesh S, Sharma S. Inside the impulsive brain: a narrative review on the role of neurobiological, hormonal and genetic factors influencing impulsivity in psychiatric disorders. Egypt J Neurol Psychiatr Neurosurg. 2025;61(1):4.
  • 17. Hüpen P, Kumar H, Müller D, Swaminathan R, Habel U, Weidler C. Functional Brain Network of Trait Impulsivity: Whole‐Brain Functional Connectivity Predicts Self‐Reported Impulsivity. Hum Brain Mapp. 2024;45(15):e70059.
  • 18. Yazici K, Yazici AE. Dürtüselligin Nöroanatomik ve Nörokimyasal Temelleri/Neuroanatomical and Neurochemical Basis of Impulsivity. Psikiyatride Guncel Yaklasimlar. 2010;2(2):254.
  • 19. Åsberg M, Träskman L, Thorén P. 5-HIAA in the cerebrospinal fluid: A biochemical suicide predictor? Arch Gen Psychiatry. 1976;33(10):1193-1197.
  • 20. Linnoila M, Virkkunen M, Scheinin M, Nuutila A, Rimon R, Goodwin FK. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sci. 1983;33(26):2609-2614.
  • 21. Virkkunen M, Rawlings R, Tokola R, et al. CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers. Arch Gen Psychiatry. 1994;51(1):20- 27.
  • 22. Tyano S, Zalsman G, Ofek H, et al. Plasma serotonin levels and suicidal behavior in adolescents. European Neuropsychopharmacology. 2006;16(1):49-57.
  • 23. Biederman J, Mick E, Surman C, et al. A randomized, placebo-controlled trial of OROS methylphenidate in adults with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2006;59(9):829-835.
  • 24. Robinson EJ, Eagle DM, Bannerjee G, Robbins TW. Effects of atomoxetine on inhibitory control in the rat stop-signal task. J Psychopharmacol. 2006;20:A67.
  • 25. Blondeau C, Dellu-Hagedorn F. Dimensional analysis of ADHD subtypes in rats. Biol Psychiatry. 2007;61(12):1340-1350.
  • 26. Thomason C, Michelson D. Atomoxetine--treatment of attention deficit hyperactivity disorder: beyond stimulants. Drugs Today (Barc). 2004;40(5):465-473.
  • 27. Greenhill LL, Biederman J, Boellner SW, et al. A randomized, double-blind, placebo-controlled study of modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2006;45(5):503-511.
  • 28. Green R, Meredith LR, Mewton L, Squeglia LM. Adolescent neurodevelopment within the context of impulsivity and substance use. Curr Addict Rep. 2023;10(2):166-177.
  • 29. Kruger DJ, Nesse RM. An evolutionary life-history framework for understanding sex differences in human mortality rates. Human nature. 2006;17:74-97.
  • 30. Cross CP, Copping LT, Campbell A. Sex differences in impulsivity: a meta-analysis. Psychol Bull. 2011;137(1):97.
  • 31. Wilson M, Daly M. Competitiveness, risk taking, and violence: The young male syndrome. Ethol Sociobiol. 1985;6(1):59-73.
  • 32. Abbott MS, Seaman Jr RW, Doyle MR, Maguire DR, Rice KC, Collins GT. Interactions between impulsivity and MDPV self‐administration in rats. Addiction biology. 2022;27(3):e13168.
  • 33. Boonstra AM, Oosterlaan J, Sergeant JA, Buitelaar JK. Executive functioning in adult ADHD: a meta-analytic review. Psychol Med. 2005;35(8):1097-1108.
  • 34. Lijffijt M, Kenemans JL, Verbaten MN, van Engeland H. A meta-analytic review of stopping performance in attention-deficit/hyperactivity disorder: deficient inhibitory motor control? J Abnorm Psychol. 2005;114(2):216.
  • 35. Uhre VF, Larsen KM, Herz DM, Baaré W, Pagsberg AK, Siebner HR. Inhibitory control in obsessive compulsive disorder: A systematic review and activation likelihood estimation meta-analysis of functional magnetic resonance imaging studies. Neuroimage Clin. 2022;36:103268.
  • 36. Chamberlain SR, Fineberg NA, Blackwell AD, Robbins TW, Sahakian BJ. Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. American journal of psychiatry. 2006;163(7):1282-1284.
  • 37. Penades R, Catalan R, Rubia K, Andres S, Salamero M, Gasto C. Impaired response inhibition in obsessive compulsive disorder. European Psychiatry. 2007;22(6):404-410.
  • 38. Monterosso JR, Aron AR, Cordova X, Xu J, London ED. Deficits in response inhibition associated with chronic methamphetamine abuse. Drug Alcohol Depend. 2005;79(2):273-277.
  • 39. Eysenck SBG, Pearson PR, Easting G, Allsopp JF. Age norms for impulsiveness, venturesomeness and empathy in adults. Pers Individ Dif. 1985;6(5):613-619.
  • 40. Matthys W, Van Goozen SHM, De Vries H, Cohen-Kettenis PT, Van Engeland H. The dominance of behavioural activation over behavioural inhibition in conduct disordered boys with or without attention deficit hyperactivity disorder. The Journal of Child Psychology and Psychiatry and Allied Disciplines. 1998;39(5):643- 651.
  • 41. Halperin JM, Wolf LE, Pascualvaca DM, et al. Differential assessment of attention and impulsivity in children. J Am Acad Child Adolesc Psychiatry. 1988;27(3):326-329.
  • 42. Dougherty DM, Moeller FG, Steinberg JL, Marsh DM, Hines SE, Bjork JM. Alcohol increases commission error rates for a continuous performance test. Alcohol Clin Exp Res. 1999;23(8):1342-1351.
  • 43. Evenden JL. The pharmacology of impulsive behaviour in rats VII: the effects of serotonergic agonists and antagonists on responding under a discrimination task using unreliable visual stimuli. Psychopharmacology (Berl). 1999;146:422-431.
  • 44. Puumala T, Sirviö J. Changes in activities of dopamine and serotonin systems in the frontal cortex underlie poor choice accuracy and impulsivity of rats in an attention task. Neuroscience. 1998;83(2):489-499.
  • 45. Lamichhane B, Moukaddam N, Salas R, Goodman W, Sabharwal A. Multimodal objective assessment of impulsivity in healthy and mood disorder participants. NPP—Digital Psychiatry and Neuroscience. 2025;3(1):6.
  • 46. Özdemir PG, Selvi Y, Aydin A. Dürtüsellik ve tedavisi. Psikiyatride Güncel Yaklaşımlar. 2012;4(3):293-314.
  • 47. Tamam L, Döngel B. Yıkıcı bozukluklar, dürtü kontrol ve davranım bozuklukları. In: Temel ve Klinik Psikiyatri. 1st ed. Ankara, Güneş Yayınevi, 2018.
  • 48. Cuthbert BN, Insel TR. Toward the future of psychiatric diagnosis: the seven pillars of RDoC. BMC Med. 2013;11:1-8.
  • 49. Gray JA. A model of the limbic system and basal ganglia: Applications to anxiety and schizophrenia. In: The Cognitive Neurosciences. 1st ed. Ed: Gazzaniga MS: 1165–1176. Cambridge (MA), The MIT Press, 1995.
  • 50. Rachlin H. The Science of Self-Control. Cambridge (MA), Harvard University Press, 2004.
  • 51. Damasio AR, Tranel D, Damasio H. Individuals with sociopathic behavior caused by frontal damage fail to respond autonomically to social stimuli. Behavioural brain research. 1990;41(2):81-94.
  • 52. Swann AC, Janicak PL, Calabrese JR, et al. Structure of mania: subgroups with distinct clinical characteristics and course of illness in randomized clinical trial participants. J Affect Disord. 2001;67(1-3):123-132.
  • 53. Marzilli E, Cerniglia L, Cimino S. Antisocial personality problems in emerging adulthood: The role of family functioning, impulsivity, and empathy. Brain Sci. 2021;11(6):687.
  • 54. Barratt ES, Stanford MS, Kent TA, Alan F. Neuropsychological and cognitive psychophysiological substrates of impulsive aggression. Biol Psychiatry. 1997;41(10):1045-1061.
  • 55. Barratt ES, Stanford MS, Felthous AR, Kent TA. The effects of phenytoin on impulsive and premeditated aggression: a controlled study. J Clin Psychopharmacol. 1997;17(5):341-349.
  • 56. Coccaro EF, Siever LJ, Klar HM, et al. Serotonergic studies in patients with affective and personality disorders: correlates with suicidal and impulsive aggressive behavior. Arch Gen Psychiatry. 1989;46(7):587- 599.
  • 57. Leichsenring F, Fonagy P, Heim N, et al. Borderline personality disorder: a comprehensive review of diagnosis and clinical presentation, etiology, treatment, and current controversies. World psychiatry. 2024;23(1):4-25.
  • 58. Links PS, Heslegrave R, Reekum R van. Impulsivity: core aspect of borderline personality disorder. J Pers Disord. 1999;13(1):1-9.
  • 59. Soloff PH, Lynch KG, Kelly TM, Malone KM, Mann JJ. Characteristics of suicide attempts of patients with major depressive episode and borderline personality disorder: a comparative study. American Journal of Psychiatry. 2000;157(4):601-608.
  • 60. Soloff PH, Lis JA, Kelly T, Cornelius J, Ulrich R. Risk factors for suicidal behavior in borderline personality disorder. Am J Psychiatry. 1994;151(9):1316-1323.
  • 61. Mann JJ, Waternaux C, Haas GL, Malone KM. Toward a clinical model of suicidal behavior in psychiatric patients. American journal of Psychiatry. 1999;156(2):181-189.
  • 62. Dougherty DM, Bjork JM, Huckabee HCG, Moeller FG, Swann AC. Laboratory measures of aggression and impulsivity in women with borderline personality disorder. Psychiatry Res. 1999;85(3):315-326.
  • 63. Moeller FG, Barratt ES, Dougherty DM, Schmitz JM, Swann AC. Psychiatric aspects of impulsivity. American journal of psychiatry. 2001;158(11):1783-1793.
  • 64. Özdemir PG, Selvi Y, Aydin A. Dürtüsellik ve tedavisi. Psikiyatride Güncel Yaklaşımlar. 2012;4(3):293-314.
  • 65. Chan CC, Alter S, Hazlett EA, et al. Neural correlates of impulsivity in bipolar disorder: A systematic review and clinical implications. Neurosci Biobehav Rev. 2023;147:105109.
  • 66. Brady KT, Myrick H, McElroy S. The relationship between substance use disorders, impulse control disorders, and pathological aggression. American Journal on Addictions. 1998;7(3):221-230.
  • 67. Patton JH, Stanford MS, Barratt ES. Factor structure of the Barratt impulsiveness scale. J Clin Psychol. 1995;51(6):768-774.
  • 68. Allen TJ, Moeller FG, Rhoades HM, Cherek DR. Impulsivity and history of drug dependence. Drug Alcohol Depend. 1998;50(2):137-145.
  • 69. McCOWN WG. Multi‐impulsive Personality Disorder and Multiple Substance Abuse: evidence from members of self‐help groups. Br J Addict. 1988;83(4):431-432.
  • 70. O’Boyle M, Barratt ES. Impulsivity and DSM-III-R personality disorders. Pers Individ Dif. 1993;14(4):609-611.
  • 71. Kirby KN, Petry NM, Bickel WK. Heroin addicts have higher discount rates for delayed rewards than non-drug-using controls. J Exp Psychol Gen. 1999;128(1):78.
  • 72. Mitchell SH. Measures of impulsivity in cigarette smokers and non-smokers. Psychopharmacology (Berl). 1999;146:455-464.
  • 73. Marx I, Hacker T, Yu X, Cortese S, Sonuga-Barke E. ADHD and the choice of small immediate over larger delayed rewards: a comparative meta-analysis of performance on simple choice-delay and temporal discounting paradigms. J Atten Disord. 2021;25(2):171-187.
  • 74. Babinski LM, Hartsough CS, Lambert NM. Childhood conduct problems, hyperactivity-impulsivity, and inattention as predictors of adult criminal activity. The Journal of Child Psychology and Psychiatry and Allied Disciplines. 1999;40(3):347-355.
  • 75. O’TOOLE K, Abramowitz A, Morris R, Dulcan M. Effects of methylphenidate on attention and nonverbal learning in children with attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 1997;36(4):531-538.
  • 76. Halperin JM, Wolf LE, Pascualvaca DM, et al. Differential assessment of attention and impulsivity in children. J Am Acad Child Adolesc Psychiatry. 1988;27(3):326-329.
  • 77. Senkowski D, Ziegler T, Singh M, et al. Assessing inhibitory control deficits in adult ADHD: A systematic review and meta-analysis of the stop-signal task. Neuropsychol Rev. 2024;34(2):548-567.
  • 78. Bauer J, Werner A, Kohl W, et al. Hyperactivity and impulsivity in adult attention-deficit/hyperactivity disorder is related to glutamatergic dysfunction in the anterior cingulate cortex. The world journal of biological psychiatry. 2018;19(7):538-546.
  • 79. Camacho-Barcia L, Giel KE, Jiménez-Murcia S, et al. Eating disorders and obesity: bridging clinical, neurobiological, and therapeutic perspectives. Trends Mol Med. 2024;30(4):361-379. doi:https://doi.org/10.1016/j.molmed.2024.02.007
  • 80. Davis HA, Smith GT. Examining the role of urgency in predicting binge size in bulimia nervosa. Front Psychol. 2023;14:1166119.
  • 81. Welch SL, Fairburn CG. Impulsivity or comorbidity in bulimia nervosa: A controlled study of deliberate self-harm and alcohol and drug misuse in a community sample. The British Journal of Psychiatry. 1996;169(4):451-458.

The Psychiatric Dimensions of Impulsivity

Yıl 2025, Cilt: 34 Sayı: 3, 195 - 208, 30.09.2025
https://doi.org/10.17827/aktd.1698682

Öz

This review explores the multifaceted psychiatric dimensions of impulsivity. Defined by patterns of unplanned, rapid actions, risk-taking, and reward-seeking behavior, impulsivity is a key feature in many psychiatric disorders. Impulsive behavior patterns are observed at a clinical level in approximately 11% of individuals. Impulsivity is seen in more than 70% of attention deficit and hyperactivity disorder (ADHD) cases and significantly affects academic and social functioning in these individuals. Neurobiologically, regions such as the prefrontal and orbitofrontal cortex, along with neurotransmitter systems like serotonin, dopamine, and norepinephrine, play a critical role in impulsive behavior. Gender differences and hormonal influences also shape how impulsivity is expressed. Impulsivity is notably associated with disorders such as ADHD, personality disorders, mood disorders, and substance use disorders. Assessment methods include self-report questionnaires, behavioral laboratory tasks, and biological measurements. In conclusion, impulsivity is a complex and multidimensional behavioral pattern that plays a significant role in understanding psychiatric disorders. Future research in this field is essential to better understand the biological underpinnings of impulsivity and its role in mental illness, which will be crucial for improving therapeutic approaches.

Kaynakça

  • 1. Moore FR, Doughty H, Neumann T, McClelland H, Allott C, O’Connor RC. Impulsivity, aggression, and suicidality relationship in adults: a systematic review and meta-analysis. EClinicalMedicine. 2022;45.
  • 2. American Psychiatric Association. DSM-5 Diagnostic Classification. In: Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association, 2013.
  • 3. Nigg JT. Annual Research Review: On the relations among self‐regulation, self‐control, executive functioning, effortful control, cognitive control, impulsivity, risk‐taking, and inhibition for developmental psychopathology. Journal of child psychology and psychiatry. 2017;58(4):361-383.
  • 4. Eysenck SBG, Eysenck HJ. The place of impulsiveness in a dimensional system of personality description. British Journal of Social and Clinical Psychology. 1977;16(1):57-68.
  • 5. Patton JH, Stanford MS, Barratt ES. Factor structure of the Barratt impulsiveness scale. J Clin Psychol. 1995;51(6):768-774.
  • 6. Ainslie G. Specious reward: a behavioral theory of impulsiveness and impulse control. Psychol Bull. 1975;82(4):463.
  • 7. Hollander E, Evers M. New developments in impulsivity. The Lancet. 2001;358(9286):949-950.
  • 8. Moeller FG, Barratt ES, Dougherty DM, Schmitz JM, Swann AC. Psychiatric aspects of impulsivity. American journal of psychiatry. 2001;158(11):1783-1793.
  • 9. Stahl C, Voss A, Schmitz F, et al. Behavioral components of impulsivity. J Exp Psychol Gen. 2014;143(2):850.
  • 10. Cross CP, Copping LT, Campbell A. Sex differences in impulsivity: a meta-analysis. Psychol Bull. 2011;137(1):97.
  • 11. Huang Y, Luan S, Wu B, et al. Impulsivity is a stable, measurable, and predictive psychological trait. Proceedings of the National Academy of Sciences. 2024;121(24):e2321758121.
  • 12. L’Abate L. A family theory of impulsivity. In: The impulsive client: Theory, research, and treatment. 1st ed. Ed(s): McCown WG, Johnson JL, Shure MB: 93–117. Washington, DC, American Psychological Association, 1993.
  • 13. Barratt ES, Stanford MS, Kent TA, Alan F. Neuropsychological and cognitive psychophysiological substrates of impulsive aggression. Biol Psychiatry. 1997;41(10):1045-1061.
  • 14. Linnoila M, Virkkunen M, Scheinin M, Nuutila A, Rimon R, Goodwin FK. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sci. 1983;33(26):2609-2614.
  • 15. Barratt ES, Stanford MS, Felthous AR, Kent TA. The effects of phenytoin on impulsive and premeditated aggression: a controlled study. J Clin Psychopharmacol. 1997;17(5):341-349.
  • 16. Raji H, Dinesh S, Sharma S. Inside the impulsive brain: a narrative review on the role of neurobiological, hormonal and genetic factors influencing impulsivity in psychiatric disorders. Egypt J Neurol Psychiatr Neurosurg. 2025;61(1):4.
  • 17. Hüpen P, Kumar H, Müller D, Swaminathan R, Habel U, Weidler C. Functional Brain Network of Trait Impulsivity: Whole‐Brain Functional Connectivity Predicts Self‐Reported Impulsivity. Hum Brain Mapp. 2024;45(15):e70059.
  • 18. Yazici K, Yazici AE. Dürtüselligin Nöroanatomik ve Nörokimyasal Temelleri/Neuroanatomical and Neurochemical Basis of Impulsivity. Psikiyatride Guncel Yaklasimlar. 2010;2(2):254.
  • 19. Åsberg M, Träskman L, Thorén P. 5-HIAA in the cerebrospinal fluid: A biochemical suicide predictor? Arch Gen Psychiatry. 1976;33(10):1193-1197.
  • 20. Linnoila M, Virkkunen M, Scheinin M, Nuutila A, Rimon R, Goodwin FK. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sci. 1983;33(26):2609-2614.
  • 21. Virkkunen M, Rawlings R, Tokola R, et al. CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers. Arch Gen Psychiatry. 1994;51(1):20- 27.
  • 22. Tyano S, Zalsman G, Ofek H, et al. Plasma serotonin levels and suicidal behavior in adolescents. European Neuropsychopharmacology. 2006;16(1):49-57.
  • 23. Biederman J, Mick E, Surman C, et al. A randomized, placebo-controlled trial of OROS methylphenidate in adults with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2006;59(9):829-835.
  • 24. Robinson EJ, Eagle DM, Bannerjee G, Robbins TW. Effects of atomoxetine on inhibitory control in the rat stop-signal task. J Psychopharmacol. 2006;20:A67.
  • 25. Blondeau C, Dellu-Hagedorn F. Dimensional analysis of ADHD subtypes in rats. Biol Psychiatry. 2007;61(12):1340-1350.
  • 26. Thomason C, Michelson D. Atomoxetine--treatment of attention deficit hyperactivity disorder: beyond stimulants. Drugs Today (Barc). 2004;40(5):465-473.
  • 27. Greenhill LL, Biederman J, Boellner SW, et al. A randomized, double-blind, placebo-controlled study of modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2006;45(5):503-511.
  • 28. Green R, Meredith LR, Mewton L, Squeglia LM. Adolescent neurodevelopment within the context of impulsivity and substance use. Curr Addict Rep. 2023;10(2):166-177.
  • 29. Kruger DJ, Nesse RM. An evolutionary life-history framework for understanding sex differences in human mortality rates. Human nature. 2006;17:74-97.
  • 30. Cross CP, Copping LT, Campbell A. Sex differences in impulsivity: a meta-analysis. Psychol Bull. 2011;137(1):97.
  • 31. Wilson M, Daly M. Competitiveness, risk taking, and violence: The young male syndrome. Ethol Sociobiol. 1985;6(1):59-73.
  • 32. Abbott MS, Seaman Jr RW, Doyle MR, Maguire DR, Rice KC, Collins GT. Interactions between impulsivity and MDPV self‐administration in rats. Addiction biology. 2022;27(3):e13168.
  • 33. Boonstra AM, Oosterlaan J, Sergeant JA, Buitelaar JK. Executive functioning in adult ADHD: a meta-analytic review. Psychol Med. 2005;35(8):1097-1108.
  • 34. Lijffijt M, Kenemans JL, Verbaten MN, van Engeland H. A meta-analytic review of stopping performance in attention-deficit/hyperactivity disorder: deficient inhibitory motor control? J Abnorm Psychol. 2005;114(2):216.
  • 35. Uhre VF, Larsen KM, Herz DM, Baaré W, Pagsberg AK, Siebner HR. Inhibitory control in obsessive compulsive disorder: A systematic review and activation likelihood estimation meta-analysis of functional magnetic resonance imaging studies. Neuroimage Clin. 2022;36:103268.
  • 36. Chamberlain SR, Fineberg NA, Blackwell AD, Robbins TW, Sahakian BJ. Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. American journal of psychiatry. 2006;163(7):1282-1284.
  • 37. Penades R, Catalan R, Rubia K, Andres S, Salamero M, Gasto C. Impaired response inhibition in obsessive compulsive disorder. European Psychiatry. 2007;22(6):404-410.
  • 38. Monterosso JR, Aron AR, Cordova X, Xu J, London ED. Deficits in response inhibition associated with chronic methamphetamine abuse. Drug Alcohol Depend. 2005;79(2):273-277.
  • 39. Eysenck SBG, Pearson PR, Easting G, Allsopp JF. Age norms for impulsiveness, venturesomeness and empathy in adults. Pers Individ Dif. 1985;6(5):613-619.
  • 40. Matthys W, Van Goozen SHM, De Vries H, Cohen-Kettenis PT, Van Engeland H. The dominance of behavioural activation over behavioural inhibition in conduct disordered boys with or without attention deficit hyperactivity disorder. The Journal of Child Psychology and Psychiatry and Allied Disciplines. 1998;39(5):643- 651.
  • 41. Halperin JM, Wolf LE, Pascualvaca DM, et al. Differential assessment of attention and impulsivity in children. J Am Acad Child Adolesc Psychiatry. 1988;27(3):326-329.
  • 42. Dougherty DM, Moeller FG, Steinberg JL, Marsh DM, Hines SE, Bjork JM. Alcohol increases commission error rates for a continuous performance test. Alcohol Clin Exp Res. 1999;23(8):1342-1351.
  • 43. Evenden JL. The pharmacology of impulsive behaviour in rats VII: the effects of serotonergic agonists and antagonists on responding under a discrimination task using unreliable visual stimuli. Psychopharmacology (Berl). 1999;146:422-431.
  • 44. Puumala T, Sirviö J. Changes in activities of dopamine and serotonin systems in the frontal cortex underlie poor choice accuracy and impulsivity of rats in an attention task. Neuroscience. 1998;83(2):489-499.
  • 45. Lamichhane B, Moukaddam N, Salas R, Goodman W, Sabharwal A. Multimodal objective assessment of impulsivity in healthy and mood disorder participants. NPP—Digital Psychiatry and Neuroscience. 2025;3(1):6.
  • 46. Özdemir PG, Selvi Y, Aydin A. Dürtüsellik ve tedavisi. Psikiyatride Güncel Yaklaşımlar. 2012;4(3):293-314.
  • 47. Tamam L, Döngel B. Yıkıcı bozukluklar, dürtü kontrol ve davranım bozuklukları. In: Temel ve Klinik Psikiyatri. 1st ed. Ankara, Güneş Yayınevi, 2018.
  • 48. Cuthbert BN, Insel TR. Toward the future of psychiatric diagnosis: the seven pillars of RDoC. BMC Med. 2013;11:1-8.
  • 49. Gray JA. A model of the limbic system and basal ganglia: Applications to anxiety and schizophrenia. In: The Cognitive Neurosciences. 1st ed. Ed: Gazzaniga MS: 1165–1176. Cambridge (MA), The MIT Press, 1995.
  • 50. Rachlin H. The Science of Self-Control. Cambridge (MA), Harvard University Press, 2004.
  • 51. Damasio AR, Tranel D, Damasio H. Individuals with sociopathic behavior caused by frontal damage fail to respond autonomically to social stimuli. Behavioural brain research. 1990;41(2):81-94.
  • 52. Swann AC, Janicak PL, Calabrese JR, et al. Structure of mania: subgroups with distinct clinical characteristics and course of illness in randomized clinical trial participants. J Affect Disord. 2001;67(1-3):123-132.
  • 53. Marzilli E, Cerniglia L, Cimino S. Antisocial personality problems in emerging adulthood: The role of family functioning, impulsivity, and empathy. Brain Sci. 2021;11(6):687.
  • 54. Barratt ES, Stanford MS, Kent TA, Alan F. Neuropsychological and cognitive psychophysiological substrates of impulsive aggression. Biol Psychiatry. 1997;41(10):1045-1061.
  • 55. Barratt ES, Stanford MS, Felthous AR, Kent TA. The effects of phenytoin on impulsive and premeditated aggression: a controlled study. J Clin Psychopharmacol. 1997;17(5):341-349.
  • 56. Coccaro EF, Siever LJ, Klar HM, et al. Serotonergic studies in patients with affective and personality disorders: correlates with suicidal and impulsive aggressive behavior. Arch Gen Psychiatry. 1989;46(7):587- 599.
  • 57. Leichsenring F, Fonagy P, Heim N, et al. Borderline personality disorder: a comprehensive review of diagnosis and clinical presentation, etiology, treatment, and current controversies. World psychiatry. 2024;23(1):4-25.
  • 58. Links PS, Heslegrave R, Reekum R van. Impulsivity: core aspect of borderline personality disorder. J Pers Disord. 1999;13(1):1-9.
  • 59. Soloff PH, Lynch KG, Kelly TM, Malone KM, Mann JJ. Characteristics of suicide attempts of patients with major depressive episode and borderline personality disorder: a comparative study. American Journal of Psychiatry. 2000;157(4):601-608.
  • 60. Soloff PH, Lis JA, Kelly T, Cornelius J, Ulrich R. Risk factors for suicidal behavior in borderline personality disorder. Am J Psychiatry. 1994;151(9):1316-1323.
  • 61. Mann JJ, Waternaux C, Haas GL, Malone KM. Toward a clinical model of suicidal behavior in psychiatric patients. American journal of Psychiatry. 1999;156(2):181-189.
  • 62. Dougherty DM, Bjork JM, Huckabee HCG, Moeller FG, Swann AC. Laboratory measures of aggression and impulsivity in women with borderline personality disorder. Psychiatry Res. 1999;85(3):315-326.
  • 63. Moeller FG, Barratt ES, Dougherty DM, Schmitz JM, Swann AC. Psychiatric aspects of impulsivity. American journal of psychiatry. 2001;158(11):1783-1793.
  • 64. Özdemir PG, Selvi Y, Aydin A. Dürtüsellik ve tedavisi. Psikiyatride Güncel Yaklaşımlar. 2012;4(3):293-314.
  • 65. Chan CC, Alter S, Hazlett EA, et al. Neural correlates of impulsivity in bipolar disorder: A systematic review and clinical implications. Neurosci Biobehav Rev. 2023;147:105109.
  • 66. Brady KT, Myrick H, McElroy S. The relationship between substance use disorders, impulse control disorders, and pathological aggression. American Journal on Addictions. 1998;7(3):221-230.
  • 67. Patton JH, Stanford MS, Barratt ES. Factor structure of the Barratt impulsiveness scale. J Clin Psychol. 1995;51(6):768-774.
  • 68. Allen TJ, Moeller FG, Rhoades HM, Cherek DR. Impulsivity and history of drug dependence. Drug Alcohol Depend. 1998;50(2):137-145.
  • 69. McCOWN WG. Multi‐impulsive Personality Disorder and Multiple Substance Abuse: evidence from members of self‐help groups. Br J Addict. 1988;83(4):431-432.
  • 70. O’Boyle M, Barratt ES. Impulsivity and DSM-III-R personality disorders. Pers Individ Dif. 1993;14(4):609-611.
  • 71. Kirby KN, Petry NM, Bickel WK. Heroin addicts have higher discount rates for delayed rewards than non-drug-using controls. J Exp Psychol Gen. 1999;128(1):78.
  • 72. Mitchell SH. Measures of impulsivity in cigarette smokers and non-smokers. Psychopharmacology (Berl). 1999;146:455-464.
  • 73. Marx I, Hacker T, Yu X, Cortese S, Sonuga-Barke E. ADHD and the choice of small immediate over larger delayed rewards: a comparative meta-analysis of performance on simple choice-delay and temporal discounting paradigms. J Atten Disord. 2021;25(2):171-187.
  • 74. Babinski LM, Hartsough CS, Lambert NM. Childhood conduct problems, hyperactivity-impulsivity, and inattention as predictors of adult criminal activity. The Journal of Child Psychology and Psychiatry and Allied Disciplines. 1999;40(3):347-355.
  • 75. O’TOOLE K, Abramowitz A, Morris R, Dulcan M. Effects of methylphenidate on attention and nonverbal learning in children with attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 1997;36(4):531-538.
  • 76. Halperin JM, Wolf LE, Pascualvaca DM, et al. Differential assessment of attention and impulsivity in children. J Am Acad Child Adolesc Psychiatry. 1988;27(3):326-329.
  • 77. Senkowski D, Ziegler T, Singh M, et al. Assessing inhibitory control deficits in adult ADHD: A systematic review and meta-analysis of the stop-signal task. Neuropsychol Rev. 2024;34(2):548-567.
  • 78. Bauer J, Werner A, Kohl W, et al. Hyperactivity and impulsivity in adult attention-deficit/hyperactivity disorder is related to glutamatergic dysfunction in the anterior cingulate cortex. The world journal of biological psychiatry. 2018;19(7):538-546.
  • 79. Camacho-Barcia L, Giel KE, Jiménez-Murcia S, et al. Eating disorders and obesity: bridging clinical, neurobiological, and therapeutic perspectives. Trends Mol Med. 2024;30(4):361-379. doi:https://doi.org/10.1016/j.molmed.2024.02.007
  • 80. Davis HA, Smith GT. Examining the role of urgency in predicting binge size in bulimia nervosa. Front Psychol. 2023;14:1166119.
  • 81. Welch SL, Fairburn CG. Impulsivity or comorbidity in bulimia nervosa: A controlled study of deliberate self-harm and alcohol and drug misuse in a community sample. The British Journal of Psychiatry. 1996;169(4):451-458.
Toplam 81 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sinirbilim (Diğer)
Bölüm Derleme
Yazarlar

Caner Yeşiloğlu 0000-0002-9997-351X

Tunahan Sun 0000-0002-1383-3154

Mehmet Emin Demirkol 0000-0003-3965-7360

Lut Tamam 0000-0002-9750-7531

Erken Görünüm Tarihi 24 Eylül 2025
Yayımlanma Tarihi 30 Eylül 2025
Gönderilme Tarihi 13 Mayıs 2025
Kabul Tarihi 26 Ağustos 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 34 Sayı: 3

Kaynak Göster

AMA Yeşiloğlu C, Sun T, Demirkol ME, Tamam L. Psikiyatrik Boyutlarıyla Dürtüsellik. aktd. Eylül 2025;34(3):195-208. doi:10.17827/aktd.1698682