Yeni Floresans Özellikli Çapraz Bağlı Polifosfazen Mikrokürelerin Sentezi ve Karakterizasyonu

Yıl 2020, , 418 - 425, 30.06.2020

Simge Metinoğlu Örüm

https://doi.org/10.35414/akufemubid.701698

Öz

Siklomatriks yapılı net-poli(siklotetrafosfazen-ko-tiramin) mikroküreler çöktürme polimerizasyonu ile tek adımda sentezlenmiştir. Elde dilen mikrokürelerin karakterizasyonu SEM, EDX, FTIR, XRD ve DLS teknikleri ile yapılmıştır. Ayrıca mikrokürelerin UV ve floresans özellikleri de incelenmiş olup, mikrokürelerin 239 nm’de maksimum absorbans yaptığı belirlenmiştir. Tiramin ve mikrokürelerin katı hal floresans özellikleri, 254 nm dalga boyunda uyarılarak incelenmiştir. Tiramin çok zayıf emisyon yaparken, mikroküreler 308 nm’de şiddetli emisyon göstermiştir. Elde edilen sonuçlar, sentezlenen polifosfazen mikrokürelerin sensör, biyolojik kataliz ve görüntüleme gibi floresans uygulamalar için yüksek potansiyele sahip olduğunu göstermektedir.

Anahtar Kelimeler

Tiramin, Mikroküre, Çöktürme polimerizasyonu, Polifosfazen, Floresans

Synthesis and Characterization of Novel Fluorescent Cross-Linked Polyphosphazene Microspheres

Öz

Cyclomatrix structured net-poly(cyclotetraphosphazene-co-tyramine) microspheres were synthesized by single step precipitation polymerization. The characterization of obtained microspheres were performed by SEM, EDX, FTIR, XRD and DLS techniques. Besides, UV and fluorescence properties of microspheres were researched and it was determined that microspheres have been shown maximum absorption at 239 nm. It was investigated the fluorescence characteristics of tyramine and microspheres as solid state, using 254 nm as the excitation wavelength. The microspheres showed a strong emission peak at 308 nm, whereas the emission peak of the tyramine was very weak. The obtained results show that the synthesized polyphosphazene microspheres have a high potential for fluorescent sensor, biological catalysis and imaging applications etc. 

Anahtar Kelimeler

Tyramine, Microsphere, Precipitation polymerization, Polyphosphazene, Fluorescence

Kaynakça

• Abbas, Y., Zuhra, Z., Basharat, M., Qiu, M., Wu, Z., Wu, D. and Ali, S., 2019. Morphology control of novel cross-linked ferrocenedimethanol derivative cyclophosphazenes: from microspheres to nanotubes and their enhanced physicochemical performances. The Journal of Pysical Chemistry B., 123, 4148−4156.
• Basharat, M., Liu, W., Zhang, S., Abbas, Y., Wu, Z., and Wu, D., 2019. Poly(cyclotriphosphazene-co-tris(4-hydroxyphenyl)ethane) microspheres with intrinsic excitation wavelength tunable multicolor photoluminescence. Macromolecular Chemistry and Physics, 220, 1900256-1900264.
• Fu, J., Wang, M., Zhang, C., Zhang, P. and Xu, Q., 2012. High hydrogen storage capacity of heteroatom-containing porous carbon nanospheres produced from cross-linked polyphosphazene nanospheres. Materials Letters, 81, 215–218.
• Fu, J., Wang, S., Zhu, J., Wang, K., Gao, M., Wang, X. and Xu, Q., 2018. Au-Ag bimetallic nanoparticles decorated multi-amino cyclophosphazene hybrid microspheres as enhanced activity catalysts for the reduction of 4-nitrophenol. Materials Chemistry and Physics, 207, 315-324.
• Hong, S., Li, J., Huang, X. and Liu, H., 2018. A facile approach to generate cross-linked poly (cyclotriphosphazeneco-oxyresveratrol) nanoparticle with intrinsically fluorescence. Journal of Inorganic and Organometallic Polymers and Materials, 28, 2258–2263.
• Hou, S., Chen, S., Dong, Y., Gao, S., Zhu, B. and Lu, Q., 2018. Biodegradable cyclomatrix polyphosphazene nanoparticles: a novel ph-responsive drug self-framed delivery system. ACS Applied Materials & Interfaces, 10, 25983-25993.
• Jiang, Z., Xie, F., Kang, C., Wang, Y., Yuan, L. and Wang, Y., 2019. Adsorption of thorium(IV) from aqueous solutions by poly (cyclotriphosphazene‑co‑4,4′‑diaminodiphenyl ether) microspheres. Journal of Radioanalytical and Nuclear Chemistry, 321, 895–905.
• Liu, W., Huang, X., Wei, H., Tang, X. and Zhu, Lu., 2011. Intrinsically fluorescent nanoparticles with excellent stability based on a highly crosslinked organic–inorganic hybrid polyphosphazene material. Chemical Communications, 47, 11447–11449.
• Malkappa, K. and Ray, S.S., 2019. Thermal stability, pyrolysis behavior, and fire-retardant performance of melamine cyanurate@poly(cyclotriphosphazene-co-4,4′-sulfonyl diphenol) hybrid nanosheet-containing polyamide 6 composites. ACS Omega, 4, 9615−9628.
• Meng, L., Xu, C., Liu, T., Li, H., Lu, Q. and Long, J., 2015. One-pot synthesis of highly cross-linked fluorescent polyphosphazene nanoparticles for cell imaging. Polymer Chemistry, 6, 3155–3163.
• Metinoğlu Örüm, S. and Süzen Demircioğlu, Y., 2019. One-pot synthesis and characterization of crosslinked polyphosphazene dopamine microspheres for controlled drug delivery applications. Journal of Macromolecular Science, Part A Pure and Applied Chemistry, 56, 854–859.
• Pan, T., Huang, X., Wei, H., Wei, W. and Tang X.,2012. Intrinsically fluorescent microspheres with superior thermal stability and broad ultraviolet-visible absorption based on hybrid polyphosphazene material. Macromolecular Chemistry and Physics, 213, 1590−1595.
• Qiu, S., Xing, W., Feng, X., Yu, B., Mu, X., Yuen, R.K.K. and Hu, Y., 2017. Self-standing cuprous oxide nanoparticles on silica@polyphosphazene nanospheres: 3D nanostructure for enhancing the flame retardancy and toxic effluents elimination of epoxy resins via synergistic catalytic effect. Chemical Engineering Journal, 309, 802–814.
• Siddiqui, H., Bashir, M. A., Javaid, K., Nizamani, A., Bano, H., Yousuf, S., Rahman, A. and Choudhary, M. I., 2016. Ultrasonic synthesis of tyramine derivatives as novel inhibitors of a-glucosidase in vitro. Journal of Enzyme Inhibition and Medicinal Chemistry, 31, 1392–1403.
• Sun, L., Liu, T., Li, H., Yang, L., Meng, L., Lu, Q. and Long, J., 2015. Fluorescent and cross-linked organic−inorganic hybrid nanoshells for monitoring drug delivery. ACS Applied Materials Interfaces, 7, 4990−4997.
• Süzen, Y. and Metinoğlu Örüm, S., 2017. Novel cyclomatrix-type polyphosphazene microspheres crosslinked with octachlorocyclotetraphosphazene: preparation and characterization. Anadolu University Journal of Science and Technology A- Applied Sciences and Engineering, 18, 973 – 987.
• Tang, X.Z. and Huang, X.B., 2017. Modern Inorganic Synthetic Chemistry. Ruren Xu and Yan Xu, Elsevier, 279-306.
• Wan, C. and Huang, X., 2017. Cyclomatrix polyphosphazenes frameworks (Cyclo-POPs) and therelated nanomaterials: Synthesis, assembly and functionalisation. Materials Today Communications, 11, 38–60.
• Wang, D., Hu, Y., Meng, L., Wang, X. and Lub, Q., 2015. One-pot synthesis of fluorescent and cross-linked polyphosphazene nanoparticles for highly sensitive and selective detection of dopamine in body fluids. RSC Advances, 5, 92762–92768.
• Wang, Y., Mu, J., Li, L., Shi, L., Zhang, W. and Jiang, Z., 2012. Preparation and properties of novel fluorinated cross-linked polyphosphazene micro-nano spheres. High Performance Polymers, 24, 229–236.
• Wei, X., Chen, H., Tham, H. P., Zhang, N., Xing, P., Zhang, G. and Zhao, Y., 2018. Combined photodynamic and photothermal therapy using cross-linked polyphosphazene nanospheres decorated with gold nanoparticles. ACS Applied Nano Materials, 7, 3663-3672.
• Wei, X., Zhang, G., Zhou, L. and Li, J., 2017. Synthesis and characterization of hydrophobic amino-based polyphosphazene microspheres with different morphologies via two strategies. Applied Surface Science, 419, 744–752.
• Wei, W., Lu, R., Xie, H., Zhang, Y., Bai, X., Gu, L., Da, R. and Liu, X., 2015. Selective adsorption and separation of dyes from an aqueous solution on organic–inorganic hybrid cyclomatrix polyphosphazene submicro-spheres. Journal of Materials Chemistry A, 3, 4314–4322.
• Zhang, H., Lu, Y., Wu, S., Wei, Y., Liu, Q., Liu, J. and Jiao, Q., 2016. Two-step enzymatic synthesis of tyramine from raw pyruvatefermentation broth. Journal of Molecular Catalysis B: Enzymatic, 124, 38–44.