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Lipoic Acıd: An Universal Antioxidant

Yıl 2008, Cilt: 8 Sayı: 1, 231 - 245, 01.06.2008

Öz

Kaynakça

  • Aslan R., Şekeroğlu M.R., Bayıroğlu F., Serbest radikal türlerin membran lipid peroksidasyonuna etkileri ve hücresel antioksidan savunma. Sağlık Bil. Derg.; 2: 137-142. (1995).
  • Byung P.Y., Cellular defenses against damage from reactive species. Aphysiologycal Reviews; 74(1): 139-172. (1994).
  • Dündar Y., Aslan R., Hekimlikte oksidatif stres ve antiokasidanlar. Afyon Kocatepe Üniversiresi Yayınları, Ankara; Yayın No: 29 (1): 5,6,9-11,30,52. (2000).
  • Bullock M.W., Brockamann J.A., Patterson E.L.,Pierce J.V.,Macchi M.E., Proposed structures for protogen-A and protogen-B.J.Am.Chem Soc; 76:1827-1828. (1954)
  • Gutteridge J.M., Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin. Chem.; 41(12): 1819-1828. (1995).
  • Snell E.E.,Strong F.M.,Peterson W.H., Growth factors for bacteria. Biochem J; 31:1789-1799. .(1937).
  • Reed L.J., Busk B.G., Gunsalus I.C., Schnakenberg G.H.F., Crystalline a lipoic-acid: a catalytic agent associated with pyruvate dehydrogenase. Science; 114:93. (1950).
  • Morris T.W., Reed K.E., Cronan J.E., Lipoic acid metabolism in Escherichia coli: the IpIA and libB genes define redundant pathways for ligation of lipoyl groups to apoprotein. J.Bacteriol; 177:1-10. (1995).
  • Kramer K., Nutra ceutials in Heath and Disease Prevention. Marcel Dekker Incorporated, New York; 8:113. (2001).
  • Cadenas E., Handbook of antioxidants (2nd ed). Marcel Dekker Incorporated, Newyork; 23:473. (2001).
  • Gözükara E.M., Biyokimya. İnönü Üniversitesi Tıp Fakültesi yayınları, Malatya; 55,56,705,845-848. (1989).
  • Streeper R.S., Henriksen E.J., Jacob S., Hokama J.Y., Donovan L.F., Tritschler H.J., Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. Am. J.Physiol; 273:E185-E191. (1997).
  • Aalt Bast and Guido R.M.M. Haenen., The toxicity of antioxidants and their metabolites. Environmental toxicology and Pharmacology. Volume 11, Issues 3-4, July 2002, 251-258. (2002).
  • Cadenas, Enrique., Handbook of Antioxidants, Second Edition, Revised and Expanded. New York,NY,USA: Marcel Dekker İncorporated, 477- 478. (2001).
  • Kagan V.E., Shvedova A., Serbinova E., Dihidrolipoic acid-a universal antioxidant both in the membrane and in the aqueous phase. Reductıon of peroxyl, ascorbyl and chromanoxyl radicals. Biochem pharmacol; 44:1637-1649. (1992).
  • Persson L.H., Brunk U.T., A lysomotropic form of alpha-lipoic acid: a possible therapy of diabetic complications?. Div.of Pathology H, University Hospital, Linkoping, Sweden. ( 2000 ).
  • Evans JL, Haymann CS, Goldfire ID , Gavin LA., Endocr Pract. Pharmocokinetics, tolerability and fructosamine lowering effect of a novel, controlled-relese formulation of alpha-lipoic acid; Jan-Feb; 8(1): 29-35. (2002).
  • Herbert A.A., Guest J.R., Lipoic acid content of Escherichia coli and other microorganisms. Arch Microbiol; 106:259-266. (1975).
  • Busby R:W, Schelvis J.P.M., Yu D.S., Babcock G.t., Marletta M.a. Lipoic acid biosynthesis: Lip A is an Iron- Sulfur protein. J. Am.Chem. Soc.; 121: 4706-4707. (1999).
  • Biewenga G., Haenen G.R., Bast A. The pharmacology of the antioxidant lipoic acid. Gen Pharmac.; 29: 315-331. (1997).
  • Yasuno R., Wada H. The biosynthetic pathway for lipoic acid is present in plastids and mitochondria in arabidopsis Thaliana. FEBS Lett.; 517:110-114. (2002).
  • Perham R.N., Domains, motifs and linkers in 2-oxo-acid dehydrogenase multienzyme complexes: a paradigm in the desing of a multifunctional protein. Biochemistry; 30: 8501-8512. (1991).
  • Peinado J., Sies H., Akerboom T.P., Hepatic lipoate uptake. Arch. Biochem. Biophys.; 273: 389-395. (1989).
  • Cremer D.R., Rabeler R., Roberts A., Lynch B. Safety evaluation of α- lipoic acid (ALA). Regulatory Toxicology and Pharmacology. Volume 46, Issue 1, October 2006, Pages 29-41. (2006).
  • Josephv T.Spence AND Donald B. Mc Cormick., Lipoic acid metabolism in the rat. Available on line 2004. ( 1975).
  • Teichert J,Hermann R,Ruus P, Preiss R., Plasma kinetics,metabolism and urinary excretion of alpha-lipoic acid following oral administration in healty volunters. J. Clin Pharmacol. Nov ; 43(11): 257-67. (2003).
  • Ersoy E., Bayşu N., Biyokimya. Ankara Üniversitesi Veteriner Fakültesi Yayınları, Ankara.: 454. (1986).
  • Gözükara E.M., Biyokimya. İnönü Üniversitesi Tıp Fakültesi yayınları, Malatya; 55,56,705,845-848. (1989).
  • Navari-Izzo F., Quartacci M.F., Sgherri C., Lipoic acid: a unique antioxidant in the detoxification of activated oxygen species. Plant Physiol. Biochem; 40: 463-470. (2002).
  • Busse E., Zimmer G., Schopohl B., Kornhuber B., Influence of -lipoic acid on intracellular glutathione in vitro and in vivo. Arzneim- Forsch/Drug Res.; 42: 829-832. (1992).
  • Packer L., Witt E., Tritschler H.J., -Lipoic acid as a biological antioxidant. Science Direct-Free Radical Biology & Medicine; 19(2): 227-250. (1995).
  • Han D., Handelman G., Marcocci L., Sen C.K., Roy S., Kobuchi H., Flohe L., Packer L., Lipoic acid increases de novo synthesis of cellular glutathione by improving cysteine utilization. Biofactors; 6: 321-338. (1997).
  • Podda M., Tritschler H.J., Ulrich H., Packer L., -Lipoic acid supplementation prevents symptoms of vitamin E deficiency. Biochem. Biophys. Res. Commun.; 204: 98-104. (1994).
  • Sen C.K., Roy S., Han D., Packer L., Regulation of cellular thiols on human lymphocytes by alpha-lipoic acid: a flow cytometric analysis. Free Rad. Biol. Med.; 22: 1241-1257. (1997).
  • Sen C.K.. Roy S., Packer L., -Lipoic acid: cell regulatory function and potential therapeutic implications. San Diego; Academic Press: 111-119. (1999).
  • Haenen G.R.M.M., Bast A., Protection against lipid peroxidation by a microsomal glutathione-dependent labile factor. FEBS Lett.; 159: 24-28. (1983).
  • Quartacci M.F., Sgherri C., Lipoic acid: a unique antioxidant in the detoxification of actived oxygen species. Plant Physiol.Biochem; 40: 463-470. (2002).
  • Ou P., Tritschler H.J., Wolff S.P., Thioctic (lipoic) acid : a therapeutic metal-chelating antioxidant? Biochem Pharmacol; 50(1): 123-126. (1995).

LİPOİK ASİT: EVRENSEL ANTİOKSİDAN

Yıl 2008, Cilt: 8 Sayı: 1, 231 - 245, 01.06.2008

Öz

Alfa lipoik asit bazı yiyeceklerde bulunan ve aynı zamanda vücutta sentezlenen doğal bir maddedir. Serbest radikal hasarını önleyen lipoik asit yağda ve suda çözünebilmesi açısından antioksidanlar arasında tektir. İnsanlarda lipoik asit enerji oluşumunu içeren çeşitli 2-oksoasit dehidrogenazların bir parçasıdır. Okside lipoik asit ve redükte lipoik asit olarak 2 formu bulunmaktadır. Redükte lipoik aside dihidrolipoik asit de denmektedir. Dihidrolipoik asit biyolojik olarak daha aktiftir. Lipoik asit mitokondride oktanoik asit ve bir sülfür kaynağından sentez edilmektedir. Lipoik asit oral verildiğinde % 93’den fazlası barsaktan emilir, karaciğerde metabolizmayla % 20-30 ilk geçiş etkisine uğrar. α-Lipoik asidin insanlardaki primer metabolik yolu S-metilasyon β-oksidasyondur. Lipoik asit açil taşıyıcı olup iki elektron taşımakla görevlidir. α- ketoglutarat dehidrogenaz ile pirüvat dehidrogenaz enzim kompleksleri içinde bulunur. Lipoik asit pirüvatın oksidatif dekarboksilasyonunda koenzim olarak görev yapmaktadır. Lipoik asidin serbest radikal hasarını uzaklaştıran vitamin E ve vitamin C’ yi rejenere ettiği gösterilmiştir.

Kaynakça

  • Aslan R., Şekeroğlu M.R., Bayıroğlu F., Serbest radikal türlerin membran lipid peroksidasyonuna etkileri ve hücresel antioksidan savunma. Sağlık Bil. Derg.; 2: 137-142. (1995).
  • Byung P.Y., Cellular defenses against damage from reactive species. Aphysiologycal Reviews; 74(1): 139-172. (1994).
  • Dündar Y., Aslan R., Hekimlikte oksidatif stres ve antiokasidanlar. Afyon Kocatepe Üniversiresi Yayınları, Ankara; Yayın No: 29 (1): 5,6,9-11,30,52. (2000).
  • Bullock M.W., Brockamann J.A., Patterson E.L.,Pierce J.V.,Macchi M.E., Proposed structures for protogen-A and protogen-B.J.Am.Chem Soc; 76:1827-1828. (1954)
  • Gutteridge J.M., Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin. Chem.; 41(12): 1819-1828. (1995).
  • Snell E.E.,Strong F.M.,Peterson W.H., Growth factors for bacteria. Biochem J; 31:1789-1799. .(1937).
  • Reed L.J., Busk B.G., Gunsalus I.C., Schnakenberg G.H.F., Crystalline a lipoic-acid: a catalytic agent associated with pyruvate dehydrogenase. Science; 114:93. (1950).
  • Morris T.W., Reed K.E., Cronan J.E., Lipoic acid metabolism in Escherichia coli: the IpIA and libB genes define redundant pathways for ligation of lipoyl groups to apoprotein. J.Bacteriol; 177:1-10. (1995).
  • Kramer K., Nutra ceutials in Heath and Disease Prevention. Marcel Dekker Incorporated, New York; 8:113. (2001).
  • Cadenas E., Handbook of antioxidants (2nd ed). Marcel Dekker Incorporated, Newyork; 23:473. (2001).
  • Gözükara E.M., Biyokimya. İnönü Üniversitesi Tıp Fakültesi yayınları, Malatya; 55,56,705,845-848. (1989).
  • Streeper R.S., Henriksen E.J., Jacob S., Hokama J.Y., Donovan L.F., Tritschler H.J., Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. Am. J.Physiol; 273:E185-E191. (1997).
  • Aalt Bast and Guido R.M.M. Haenen., The toxicity of antioxidants and their metabolites. Environmental toxicology and Pharmacology. Volume 11, Issues 3-4, July 2002, 251-258. (2002).
  • Cadenas, Enrique., Handbook of Antioxidants, Second Edition, Revised and Expanded. New York,NY,USA: Marcel Dekker İncorporated, 477- 478. (2001).
  • Kagan V.E., Shvedova A., Serbinova E., Dihidrolipoic acid-a universal antioxidant both in the membrane and in the aqueous phase. Reductıon of peroxyl, ascorbyl and chromanoxyl radicals. Biochem pharmacol; 44:1637-1649. (1992).
  • Persson L.H., Brunk U.T., A lysomotropic form of alpha-lipoic acid: a possible therapy of diabetic complications?. Div.of Pathology H, University Hospital, Linkoping, Sweden. ( 2000 ).
  • Evans JL, Haymann CS, Goldfire ID , Gavin LA., Endocr Pract. Pharmocokinetics, tolerability and fructosamine lowering effect of a novel, controlled-relese formulation of alpha-lipoic acid; Jan-Feb; 8(1): 29-35. (2002).
  • Herbert A.A., Guest J.R., Lipoic acid content of Escherichia coli and other microorganisms. Arch Microbiol; 106:259-266. (1975).
  • Busby R:W, Schelvis J.P.M., Yu D.S., Babcock G.t., Marletta M.a. Lipoic acid biosynthesis: Lip A is an Iron- Sulfur protein. J. Am.Chem. Soc.; 121: 4706-4707. (1999).
  • Biewenga G., Haenen G.R., Bast A. The pharmacology of the antioxidant lipoic acid. Gen Pharmac.; 29: 315-331. (1997).
  • Yasuno R., Wada H. The biosynthetic pathway for lipoic acid is present in plastids and mitochondria in arabidopsis Thaliana. FEBS Lett.; 517:110-114. (2002).
  • Perham R.N., Domains, motifs and linkers in 2-oxo-acid dehydrogenase multienzyme complexes: a paradigm in the desing of a multifunctional protein. Biochemistry; 30: 8501-8512. (1991).
  • Peinado J., Sies H., Akerboom T.P., Hepatic lipoate uptake. Arch. Biochem. Biophys.; 273: 389-395. (1989).
  • Cremer D.R., Rabeler R., Roberts A., Lynch B. Safety evaluation of α- lipoic acid (ALA). Regulatory Toxicology and Pharmacology. Volume 46, Issue 1, October 2006, Pages 29-41. (2006).
  • Josephv T.Spence AND Donald B. Mc Cormick., Lipoic acid metabolism in the rat. Available on line 2004. ( 1975).
  • Teichert J,Hermann R,Ruus P, Preiss R., Plasma kinetics,metabolism and urinary excretion of alpha-lipoic acid following oral administration in healty volunters. J. Clin Pharmacol. Nov ; 43(11): 257-67. (2003).
  • Ersoy E., Bayşu N., Biyokimya. Ankara Üniversitesi Veteriner Fakültesi Yayınları, Ankara.: 454. (1986).
  • Gözükara E.M., Biyokimya. İnönü Üniversitesi Tıp Fakültesi yayınları, Malatya; 55,56,705,845-848. (1989).
  • Navari-Izzo F., Quartacci M.F., Sgherri C., Lipoic acid: a unique antioxidant in the detoxification of activated oxygen species. Plant Physiol. Biochem; 40: 463-470. (2002).
  • Busse E., Zimmer G., Schopohl B., Kornhuber B., Influence of -lipoic acid on intracellular glutathione in vitro and in vivo. Arzneim- Forsch/Drug Res.; 42: 829-832. (1992).
  • Packer L., Witt E., Tritschler H.J., -Lipoic acid as a biological antioxidant. Science Direct-Free Radical Biology & Medicine; 19(2): 227-250. (1995).
  • Han D., Handelman G., Marcocci L., Sen C.K., Roy S., Kobuchi H., Flohe L., Packer L., Lipoic acid increases de novo synthesis of cellular glutathione by improving cysteine utilization. Biofactors; 6: 321-338. (1997).
  • Podda M., Tritschler H.J., Ulrich H., Packer L., -Lipoic acid supplementation prevents symptoms of vitamin E deficiency. Biochem. Biophys. Res. Commun.; 204: 98-104. (1994).
  • Sen C.K., Roy S., Han D., Packer L., Regulation of cellular thiols on human lymphocytes by alpha-lipoic acid: a flow cytometric analysis. Free Rad. Biol. Med.; 22: 1241-1257. (1997).
  • Sen C.K.. Roy S., Packer L., -Lipoic acid: cell regulatory function and potential therapeutic implications. San Diego; Academic Press: 111-119. (1999).
  • Haenen G.R.M.M., Bast A., Protection against lipid peroxidation by a microsomal glutathione-dependent labile factor. FEBS Lett.; 159: 24-28. (1983).
  • Quartacci M.F., Sgherri C., Lipoic acid: a unique antioxidant in the detoxification of actived oxygen species. Plant Physiol.Biochem; 40: 463-470. (2002).
  • Ou P., Tritschler H.J., Wolff S.P., Thioctic (lipoic) acid : a therapeutic metal-chelating antioxidant? Biochem Pharmacol; 50(1): 123-126. (1995).
Toplam 38 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

E. Gülçin Karaca Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2008
Gönderilme Tarihi 8 Ağustos 2015
Yayımlandığı Sayı Yıl 2008 Cilt: 8 Sayı: 1

Kaynak Göster

APA Karaca, E. G. (2008). LİPOİK ASİT: EVRENSEL ANTİOKSİDAN. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi, 8(1), 231-245.
AMA Karaca EG. LİPOİK ASİT: EVRENSEL ANTİOKSİDAN. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi. Haziran 2008;8(1):231-245.
Chicago Karaca, E. Gülçin. “LİPOİK ASİT: EVRENSEL ANTİOKSİDAN”. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi 8, sy. 1 (Haziran 2008): 231-45.
EndNote Karaca EG (01 Haziran 2008) LİPOİK ASİT: EVRENSEL ANTİOKSİDAN. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi 8 1 231–245.
IEEE E. G. Karaca, “LİPOİK ASİT: EVRENSEL ANTİOKSİDAN”, Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi, c. 8, sy. 1, ss. 231–245, 2008.
ISNAD Karaca, E. Gülçin. “LİPOİK ASİT: EVRENSEL ANTİOKSİDAN”. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi 8/1 (Haziran 2008), 231-245.
JAMA Karaca EG. LİPOİK ASİT: EVRENSEL ANTİOKSİDAN. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi. 2008;8:231–245.
MLA Karaca, E. Gülçin. “LİPOİK ASİT: EVRENSEL ANTİOKSİDAN”. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi, c. 8, sy. 1, 2008, ss. 231-45.
Vancouver Karaca EG. LİPOİK ASİT: EVRENSEL ANTİOKSİDAN. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi. 2008;8(1):231-45.


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