2-Aminopiridin ile (E)-4-Okso-4-((4-sülfamoyilfenil)amino)büt-2-enoik Asitin Proton Transfer Tuzunun Sentezi, Metal Komplekslerinin Hazırlanması ve hCA I ve hCA II İzoenzimleri Üzerindeki İnhibisyon Özelliklerinin İncelenmesi

Yıl 2016, Cilt: 16 Sayı: 1, 41 - 53, 30.04.2015

Cengiz Yenikaya Halil İlkimen , Mehmet Melih Demirel Burçin Ceyhan Ekrem Tunca Metin Bülbül

https://doi.org/10.5578/fmbd.24124

Cited By: 1

Öz

Bu çalışmada, ilk olarak sülfanilamit (sa) ve maleik anhidritin (mal) tepkimesinden (E)-3-(4-
sülfamoyilfenil)amino)büt-2-enoik asit (Hsamal) bileşiği sentezlenmiş ve sonra bu bileşiğin
2-aminopiridin (ap) ile proton transfer tuzu (Hapsamal) hazırlanmıştır. Bu tuzun Fe(II), Co(II),
Ni(II) ve Zn(II) geçiş metal kompleksleri sentezlenmiştir. Proton transfer tuzlarının yapısı
elementel analiz, 1H-NMR, 13C-NMR, FT-IR, UV-Vis metotları ile aydınlatılmıştır. Amorf halde
elde edilen geçiş metal komplekslerinin yapıları ise elementel analiz, ICP-OES, FT-IR, UV-Vis,
manyetik duyarlılık ve molar iletkenlik sonuçları dikkate alınarak önerilmiştir. Ayrıca,
sentezlenen maddelerin insan eritrosit hCA I ve hCA II izoenzimleri üzerindeki inhibisyon
etkilerini belirlemek üzere in vitro çalışmalar yapılmıştır. Yeni sentezlenen maddelerin
izoenzimlerin esteraz aktivitesini inhibe ettiği tespit edilmiştir. Bu maddelerin inhibisyon
değerlerinin kontrol bileşiği asetazolamid (AAZ) değerleri ile kıyaslanabilir büyüklükte olduğu
tespit edilmiştir

Anahtar Kelimeler

“Sülfamoyil Bileşikleri” “2-Aminopiridin” “Proton Transfer Tuzu” “Metal Kompleksleri” “Karbonik Anhidraz İnhibisyonu”

Kaynakça

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• Bu çalışmaya katkılarından dolayı Dumlupınar Üniversitesi Bilimsel Araştırma Projeleri Komisyonu’na teşekkür ederiz
• (Proje No: 2012/16).