Melissa officinalis Ekstraktlarının Antimikrobiyal Aktivitesinin ve DNA Koruyucu Kapasitesinin Araştırılması

Yıl 2018, Cilt: 18 Sayı: 3, 757 - 762, 30.12.2018

Safiye Elif Korcan Bilgi Aksoy Sevim Feyza Erdoğmuş , İbrahim Hakkı Ciğerci

Öz

Bu çalışmada, Melissa officinalis yaprak ekstraktlarının antimikrobiyal, antioksidan kapasiteleri ve H2O2-

indüklenmiş oksidatif hasara karşı DNA koruyucu etkisi incelendi. Melissa officinalis yaprak

ekstraktlarının oksidatif stresten DNA'yı koruyucu etkisi maya comet testi kullanılarak belirlendi. Comet

testi Saccharomyces cerevisiae BY4741 üzerinde uygulandı. Oksidatif strese karşı, ekstrenin İnkübasyon

öncesi ve inkubasyon sırasında uygulanmasında doza bağlı olarak DNA hasarında azalma gözlendi.

Sonuçlar; Melissa officinalis methanolik yaprak ekstraktlarının hidrojen peroksitin zararlı etkisine karşı

DNA'yı koruduğunu gösterdi. Ayrıca Melissa officinalis ekstraktlarının farklı mikroorganizmalar

üzerindeki antimikrobiyal etkisi incelendi. Melissa officinalis ekstraktları tüm test mikroorganizmaları

üzerinde antimikrobiyal etki göstermiştir.

Anahtar Kelimeler

Antimikrobiyal aktivite, Antioksidan, Comet testi, DNA koruyucu etki, Melissa officinalis

Kaynakça

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