Katyonik Surfaktan Varlığında Kalem Grafit Elektrot Yüzeyinde Epirubisin’in Sıyırma Voltametrisi ile Miktar Tayini

Yıl 2020, Cilt: 20 Sayı: 1, 19 - 29, 17.03.2020

Pınar Talay Pınar , Yavuz Yardım

https://doi.org/10.35414/akufemubid.621530

Cited By: 1

Öz

Bu çalışmada, bir antrasiklin ilaç olan epirubisin’in, kalem grafit elektrot kullanarak elektrokimyasal özelliklerini katyonik surfaktan varlığında Britton-Robinson tampon çözeltisinde (pH 2.0-10.0) araştırılmıştır. Öncelikle kalem grafit elektrotun performansını etkileyen parametreler örneğin, elektrot aktivasyonu, destek elektrolit seçimi, pH etkisi, biriktirme gerilimi ve süresi, surfaktan etkisi ve kare-dalga voltametrik yöntem parametreleri adsorptif sıyırma voltametrisi tekniği kullanılarak detaylı bir şekilde incelenmiştir. Daha sonra önerilen tekniklerin elde edilen en iyi koşullarında epirubisin için doğrusal aralık (0.01-2.0 µg mL^-1) ve gözlenebilme sınırı (GS; 0.0018 µg mL^-1) belirlenmiştir. Geliştirilen kare dalga adsorptif sıyırma voltametri tekniği, insan idrarına standart katma tekniğiyle uygulanmıştır.

Anahtar Kelimeler

Epirubisin; Katyonik Surfaktan; Voltametri; Kalem Grafit Elektrot; Biyolojik Örnek

Kaynakça

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