Zn2+ İyonları ile Çapraz Bağlı Sodyum Karboksimetil Selüloz Kürelerden Flurbiprofenin Kontrollü Salımı

Yıl 2021, Cilt: 21 Sayı: 3, 538 - 548, 30.06.2021

Emine Bulut

https://doi.org/10.35414/akufemubid.888787

Cited By: 2

Öz

Çalışmada, steroit olmayan anti-inflamatuar ilaç olan flurbiprofeni (FBP) kapsüllemek için sodyum karboksimetil selüloz (NaCMC) küreler Zn2+ iyonları ile çapraz bağlanarak elde edildi. Elde edilen küreler Fourier transform infrared (FTIR) spektroskopisi ve diferansiyel taramalı kalorimetri (DSC) ile karakterize edildi ve çapları optik mikroskop kullanılarak ölçüldü. Ayrıca, kürelerin denge şişme dereceleri, tutuklama değerleri, küre verim değerleri ve salım profilleri değerlendirildi. Küre verimi, tutuklama verimi ve FBP salımı üzerine NaCMC derişiminin, FBP yüklemesinin ve pH’nın etkisi incelendi. Flurbiprofenin kürelerden salımı pH 1.2 ortamında çok az iken, pH 7.4 bağırsak ortamında ise kontrollü bir şekilde gerçekleşti. NaCMC derişimi ve FBP yüklemesi arttıkça, kürelerden FBP salımı azaldı ve en yüksek ilaç salımı, NaCMC derişimi % 2 ve ilaç yüklemesi % 10 olan kürelerde gözlendi. Salım kinetikleri çoğunlukla Durum II olarak tanımlandı.

Anahtar Kelimeler

Sodyum karboksimetil selüloz, Kontrollü ilaç salımı, Flurbiprofen, Küre

Destekleyen Kurum

Afyon Kocatepe Üniversitesi

Proje Numarası

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Teşekkür

Yazar, destekleri için Afyon Kocatepe Üniversitesi BAP koordinasyon birimine ve flurbiprofeni sağladığı için Atabay Firmasına (Türkiye) teşekkür eder.

Controlled Release of Flurbiprofen from Sodium Carboxymethyl Cellulose Spheres Crosslinked with Zn2+ Ions

Öz

In the study, sodium carboxymethyl cellulose (NaCMC) spheres were obtained by crosslinking Zn2+ ions to encapsulate flurbiprofen (FBP), non-steroid anti-inflammatory drug. The spheres obtained were characterized by Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC) and their diameters were measured using an optical microscope. In addition, equilibrium swelling degrees, entrapment efficiencies, sphere yield values and release profiles of the spheres were evaluated. The effects of NaCMC concentration, FBP loading and pH on sphere yield, entrapment efficiency and FBP release were investigated. The release of flurbiprofen from the spheres was very low in pH 1.2 environment, whereas the release occurred in a controlled manner in the pH 7.4 intestinal environment. As the NaCMC concentration and FBP loading increased, FBP release from the spheres decreased and the highest drug release was observed in spheres with a NaCMC concentration of 2% and a drug loading of 10%. The release kinetics were mostly described as Case II.

Anahtar Kelimeler

Sodium carboxymethyl cellulose, Controlled drug release, Flurbiprofen, Sphere

Proje Numarası

-

Kaynakça

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