Development and Characterization of TMZ Loaded HPMC-Montmorillonite Composites

Yıl 2025, Cilt: 25 Sayı: 5, 1164 - 1171, 01.10.2025

Hakan Çiftçi , Firoozeh Panahianlarkey

https://doi.org/10.35414/akufemubid.1625984

Öz

In particular, the use of natural and large surface area natural inorganic materials such as clay minerals as carrier systems or adsorbents is important in terms of low cost. This study investigated the utility of montmorillonite (Mt) clay in both its raw form and when modified with hydroxypropyl methylcellulose (HPMC) for the encapsulation and release of temozolomide (TMZ) active ingredient. For this purpose, the raw Mt clay was first purified using the sedimentation method. Then, six different formulations were prepared using Mt, HPMC, and TMZ in different composition ratios. The release of TMZ was evaluated under simulated stomach fluid conditions at varying time intervals. As a result of the release tests, it was determined that the optimum formulation (F-6) showed best controlled release of TMZ from HPMC modified Mt. The F-6 formulation exhibited a rapid TMZ release of 50% in the first 45 min. In the later period, it was determined that the oscillation occurred more slowly for 360 min and reached approximately 90%. Korsmeyer-Peppas and Hixson kinetics provided a clear explanation of the TMZ release of the generated formulations. Nonetheless, the presence of regulated drug diffusion (Fickian mechanism) and ion exchange mechanism is linked to n coefficient values in the Korsmeyer-Peppas model being smaller than 0.5.

Anahtar Kelimeler

Montmorillonite , Bentonite , HPMC , Drug Release , Temozolomide

Destekleyen Kurum

Afyon Kocatepe Üniversitesi

Proje Numarası

23.FEN.BİL.04

Teşekkür

This study was supported by Afyon Kocatepe University, Scientific Research Projects Coordination, Afyonkarahisar, Türkiye (Grant No: 23.FEN.BİL.04).

TMZ Yüklü HPMC-Montmorillonit Kompozitlerinin Geliştirilmesi ve Karakterizasyonu

Öz

Özellikle kil mineralleri gibi doğal ve yüksek yüzey alanlı doğal inorganik malzemelerin taşıyıcı sistem veya adsorban olarak kullanılması düşük maliyet açısından önemlidir. Bu çalışmada montmorillonit (Mt) kilinin hem ham haliyle hem de hidroksipropil metilselüloz (HPMC) ile modifiye edildiğinde temozolomit (TMZ) etken maddesinin kapsüllenmesi ve salınması için kullanılabilirliğini araştırıldı. Bu amaçla, ham Mt kili ilk önce sedimantasyon (çöktürme) yöntemi kullanılarak saflaştırıldı. Daha sonra, farklı bileşim oranlarında Mt, HPMC ve TMZ kullanılarak altı farklı formülasyon hazırlandı. TMZ'nin salımı, farklı zaman aralıklarında simüle edilmiş mide sıvısı koşulları altında değerlendirildi. Salım testleri sonucunda, optimum formülasyonun (F-6) HPMC ile modifiye edilmiş Mt'den en iyi kontrollü TMZ salımı gösterdiği belirlendi. F-6 formülasyonu ilk 45 dakikada %50'lik hızlı bir TMZ salımı sergiledi. Devam eden periyotta, TMZ salımının 360 dakika boyunca daha yavaş gerçekleştiği ve yaklaşık %90'a kadar ulaştığı belirlendi. Korsmeyer-Peppas ve Hixson kinetiği, üretilen formülasyonların TMZ salımını açık bir şekilde açıkladı. Bununla birlikte, düzenlenmiş ilaç difüzyonunun (Fickian mekanizması) ve iyon değişim mekanizmasının varlığı, Korsmeyer-Peppas modelindeki n katsayısı değerlerinin 0,5'ten küçük olmasıyla bağlantılıdır.

Anahtar Kelimeler

Montmorillonit , Bentonit , HPMC , İlaç Salımı , Temozolomit

Proje Numarası

23.FEN.BİL.04

Kaynakça

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