Araştırma Makalesi
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The Global Economic Burden of Asthma Disease: A Systematic Review and Meta-Analysis

Yıl 2025, Cilt: 27 Sayı: 3, 938 - 962, 29.09.2025
https://doi.org/10.32709/akusosbil.1322364

Öz

Affecting approximately 300 million people worldwide, asthma is a major public health problem causing both premature death and poor quality of life. The disease also imposes a significant economic burden on the health care system and households. The aim of this study was to conduct a meta-analysis based on studies comparing health expenditures between patients with and without asthma and between patients with controlled and uncontrolled asthma to clarify the effect size of health expenditures due to asthma. Another aim of the research is to determine the level of health service utilisation and expenditure in patients with and without asthma and in patients with controlled and uncontrolled asthma. In the study conducted using the PICOS research question strategy, PRISMA protocol principles and flow diagram, 3 different electronic databases (Web of Science (WOS), PubMed and ScienceDirect) were searched with the search formula determined between 06 - 29 April 2023, and 16 studies were included in the analysis as a result of the search. As a result of the analysis, it was found that the effect size and the overall effect size regarding the difference between the health expenditures of patients with asthma and patients without asthma, controlled and uncontrolled asthma patients were quite high. Having (not having) asthma disease, disease level and control level are very important factors on the level of health service utilisation and health expenditures. In order to manage asthma disease, minimise the economic burden of the disease on the health system and households, ensure effectiveness in treatment, and effectively implement the plans and programmes to be prepared for the disease, it is recommended to conduct asthma prevalence surveys throughout the country.

Kaynakça

  • Aaron, S. D., Boulet, L. P., Reddel, H. K., ve Gershon, A. S. (2018). Underdiagnosis and overdiagnosis of asthma. American journal of respiratory and critical care medicine, 198(8), 1012-1020.
  • *Alefan, Q., Nawasrah, A., Almomani, B., ve Al-Issa, E. T. (2022). Direct medical cost of pediatric asthma in Jordan: A cost-of-illness retrospective cohort study. Value in Health Regional Issues, 31, 10-17.
  • *Aneeshkumar, S., ve Singh, R. B. (2018). Economic burden of asthma among patients visiting a private hospital in South India. Lung India: Official Organ of Indian Chest Society, 35(4), 312.
  • *Barbosa, J. P., Ferreira-Magalhães, M., Sá-Sousa, A., Azevedo, L. F., ve Fonseca, J. A. (2017). Cost of asthma in Portuguese adults: A population-based, cost-of-illness study. Revista Portuguesa de Pneumologia (English Edition), 23(6), 323-330.
  • Borenstein, M., Hedges, L. V., Higgins, J.P.T., Rothstein, H.R., 2009. Introduction to MetaAnalysis. John Wiley ve Sons, Ltd, Chichester, UK, UK
  • Bousquet, J., Mantzouranis, E., Cruz, A. A., Aït-Khaled, N., Baena-Cagnani, C. E., Bleecker, E. R., ... ve Zuberbier, T. (2010). Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. Journal of Allergy and Clinical Immunology, 126(5), 926-938.
  • Chastek, B., Korrer, S., Nagar, S. P., Albers, F., Yancey, S., Ortega, H., ... ve Dalal, A. A. (2016). Economic burden of illness among patients with severe asthma in a managed care setting. Journal of Managed Care ve Specialty Pharmacy, 22(7), 848-861.
  • *Chen, W., Safari, A., FitzGerald, J. M., Sin, D. D., Tavakoli, H., ve Sadatsafavi, M. (2019). Economic burden of multimorbidity in patients with severe asthma: a 20-year population-based study. Thorax, 74(12), 1113-1119.
  • Cisternas, M. G., Blanc, P. D., Yen, I. H., Katz, P. P., Earnest, G., Eisner, M. D., ... ve Yelin, E. H. (2003). A comprehensive study of the direct and indirect costs of adult asthma. Journal of allergy and clinical immunology, 111(6), 1212-1218.
  • Cleophas, J. T., ve Zwinderman, H. A. (2017). Modern meta-analysis: Review and update of methodologies. Springer International Publishing Switzerland.
  • Cohen, J. (1988). Statistical power analysis for the behavioral sciences. (2nd Edition) Hillsdale, NJ: Erlbaum.
  • Colice, G., Wu, E. Q., Birnbaum, H., Daher, M., Marynchenko, M. B., ve Varghese, S. (2006). Healthcare and workloss costs associated with patients with persistent asthma in a privately insured population. Journal of occupational and environmental medicine, 794-802.
  • Çınar, N. (2021). İyi bir sistematik derleme nasıl yazılmalı? Online Türk Sağlık Bilimleri Dergisi, 6(2), 310-314.
  • Darba, S., Safaei, N., Mahboub–Ahari, A., Nosratnejad, S., Alizadeh, G., Ameri, H., ve Yousefi, M. (2020). Direct and indirect costs associated with coronary artery (heart) disease in Tabriz, Iran. Risk Management and Healthcare Policy, 969-978.
  • *Doz, M., Chouaid, C., Com-Ruelle, L., Calvo, E., Brosa, M., Robert, J., ... ve Detournay, B. (2013). The association between asthma control, health care costs, and quality of life in France and Spain. BMC pulmonary medicine, 13, 1-10.
  • Field, A. P., ve Gillett, R. (2010). How to do a meta‐analysis. British Journal of Mathematical and Statistical Psychology, 63(3), 665-694.
  • *Finkelstein, E. A., Lau, E., Doble, B., Ong, B., ve Koh, M. S. (2021). Economic burden of asthma in Singapore. BMJ Open Respiratory Research, 8(1), e000654.
  • GBD (2019) Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 17; 396(10258):1204-1222. doi: 10.1016/S0140-6736(20)30925-9.
  • Glass, G. V., 1976. Primary, Secondary, and Meta-Analysis of Research. Educational Researcher 5, 3–8. Global Asthma Network. The global asthma report. 2018. Erişim Adresi: http://globalasthmareport.org/ resources/Global_Asthma_Report_ 2018.pdf Erişim Tarihi: 12.04.2023
  • Global Burden of Dısease, (2023). Diseases, Injuries, and Impairments. Erişim Adresi: https://www.thelancet.com/gbd/summaries Erişim Tarihi: 18. 05.2023
  • Hekking, P. P. W., Wener, R. R., Amelink, M., Zwinderman, A. H., Bouvy, M. L., ve Bel, E. H. (2015). The prevalence of severe refractory asthma. Journal of Allergy and Clinical Immunology, 135(4), 896-902.
  • Higgins, J. P., ve Thompson, S. G. (2002). Quantifying heterogeneity in a meta‐analysis. Statistics in medicine, 21(11), 1539-1558.
  • Ivanova, J. I., Bergman, R., Birnbaum, H. G., Colice, G. L., Silverman, R. A., ve McLaurin, K. (2012). Effect of asthma exacerbations on health care costs among asthmatic patients with moderate and severe persistent asthma. Journal of Allergy and Clinical Immunology, 129(5), 1229-1235.
  • Lee, L. K., Ramakrishnan, K., Safioti, G., Ariely, R., ve Schatz, M. (2020). Asthma control is associated with economic outcomes, work productivity and health-related quality of life in patients with asthma. BMJ Open Respiratory Research, 7(1), e000534.
  • *López-Tiro, J., Contreras-Contreras, A., Rodríguez-Arellano, M. E., ve Costa-Urrutia, P. (2022). Economic burden of severe asthma treatment: A real-life study. World Allergy Organization Journal, 15(7), 100662.
  • *Nagase, H., Adachi, M., Matsunaga, K., Yoshida, A., Okoba, T., Hayashi, N., ... ve Tohda, Y. (2020). Prevalence, disease burden, and treatment reality of patients with severe, uncontrolled asthma in Japan. Allergology International, 69(1), 53-60.
  • *Ng, B., Sadatsafavi, M., Safari, A., FitzGerald, J. M., ve Johnson, K. M. (2019). Direct costs of overdiagnosed asthma: a longitudinal, population-based cohort study in British Columbia, Canada. BMJ open, 9(11), e031306.
  • *Nili, M., Dwibedi, N., Adelman, M., LeMasters, T., Madhavan, S. S., ve Sambamoorthi, U. (2021). Economic burden of asthma-chronic obstructive pulmonary disease overlap among older adults in the United States. COPD: Journal of Chronic Obstructive Pulmonary Disease, 18(3), 357-366.
  • Nurmagambetov, T., Kuwahara, R., ve Garbe, P. (2018). The economic burden of asthma in the United States, 2008–2013. Annals of the American Thoracic Society, 15(3), 348-356.
  • *Nurmagambetov, T., Kuwahara, R., ve Garbe, P. (2018). The economic burden of asthma in the United States, 2008–2013. Annals of the American Thoracic Society, 15(3), 348-356.
  • *Pallegedara, A. (2018). Impacts of chronic non-communicable diseases on households’ out-of-pocket healthcare expenditures in Sri Lanka. International journal of health economics and management, 18(3), 301-319.
  • Patole, S. (Ed.). (2021). Principles and practice of systematic reviews and meta-analysis. Cham: Springer International Publishing. doi:10.1007/978-3-030-71921-0
  • *Reibman, J., Tan, L., Ambrose, C., Chung, Y., Desai, P., Llanos, J. P., ... ve Tkacz, J. (2021). Clinical and economic burden of severe asthma among US patients treated with biologic therapies. Annals of Allergy, Asthma ve Immunology, 127(3), 318-325.
  • *Roche, N., Nadif, R., Fabry-Vendrand, C., Pillot, L., Thabut, G., Teissier, C., ... ve Zins, M. (2023). Asthma burden according to treatment steps in the French population-based cohort CONSTANCES. Respiratory Medicine, 206, 107057.
  • *Sullivan, P. W., Ghushchyan, V., Navaratnam, P., Friedman, H. S., Kavati, A., Ortiz, B., ve Lanier, B. (2017). The national cost of asthma among school-aged children in the United States. Annals of allergy, asthma ve immunology, 119(3), 246-252.
  • Sullivan, S. D., Rasouliyan, L., Russo, P. A., Kamath, T., Chipps, B. E., ve TENOR Study Group. (2007). Extent, patterns, and burden of uncontrolled disease in severe or difficult‐to‐treat asthma. Allergy, 62(2), 126-133.
  • Suruki, R. Y., Daugherty, J. B., Boudiaf, N., ve Albers, F. C. (2017). The frequency of asthma exacerbations and healthcare utilization in patients with asthma from the UK and USA. BMC pulmonary medicine, 17(1), 1-11. Şen, S. ve Yıldırım, İ. (2020). CMA ile meta-analiz uygulamaları. Anı Yayıncılık.
  • The Global Asthma Report. (2022). The global asthma report 2022. The International Journal of Tuberculosis and Lung Disease, 26 (1), 1-104.
  • Vellopoulou K, Bakakos P, Loukides S, Maniadakis N, Kourlaba G. (2019). The economic burden of asthma in Greece: A cross-sectional study Appl Health Econ Health Policy. 17:629-40. doi: 10.1007/s40258-019- 00469-4. PubMed PMID: 30997609.
  • *Vellopoulou, K., Bakakos, P., Loukides, S., Maniadakis, N. ve Kourlaba, G. (2019). The economic burden of asthma in Greece: a cross-sectional study. Applied Health Economics and Health Policy, 17, 629-640.
  • WHO (2023). Asthma. Erişim Adresi: https://www.who.int/news-room/fact-sheets/detail/asthma Erişim Tarihi: 16. 05.2023.
  • Wirtz, V. J., Turpin, K., Laing, R. O., Mukiira, C. K., ve Rockers, P. C. (2018). Access to medicines for asthma, diabetes and hypertension in eight counties of Kenya. Tropical Medicine ve International Health, 23(8), 879-885.
  • Yaghoubi, M., Adibi, A., Safari, A., FitzGerald, J. M., ve Sadatsafavi, M. (2019). The projected economic and health burden of uncontrolled asthma in the United States. American journal of respiratory and critical care medicine, 200(9), 1102-1112.

Astım Hastalığının Küresel Ekonomik Yükü: Sistematik Derleme ve Meta Analiz Çalışması

Yıl 2025, Cilt: 27 Sayı: 3, 938 - 962, 29.09.2025
https://doi.org/10.32709/akusosbil.1322364

Öz

Dünya çapında yaklaşık 300 milyon insanı etkileyen astım, hem erken ölüm hem de düşük yaşam kalitesine neden olan önemli bir halk sorunudur. Bununla birlikte hastalık, sağlık sitemi ve hane halkları üzerinde ciddi ekonomik yükü de beraberinde getirmektedir. Bu araştırmanın amacı, astım hastalığı nedeniyle gerçekleşen sağlık harcamalarının etki büyüklüğünü açıklığa kavuşturmak için astımı olan ve olmayan hastalar ve kontrollü ve kontrolsüz astımı olan hastalar arasında sağlık harcamalarını karşılaştıran çalışmalara dayanan bir meta analiz gerçekleştirmektir. Araştırmanın bir diğer amacı astımı olan ve olmayan hastalarda ve kontrollü ve kontrolsüz astım hastalarında sağlık hizmeti kullanım ve harcama düzeyini ortaya koymaktır. PICOS araştırma sorusu stratejisi, PRISMA protokolü ilkeleri ve akış diyagramı kullanılarak gerçekleştirilen çalışmada, 06 - 29 Nisan 2023 tarihleri arasında belirlenen arama formülü ile 3 farklı elektronik veri tabanı (Web of Science (WOS), PubMed ve ScienceDirect) taranmış, yapılan tarama neticesinde 16 araştırma analize dâhil edilmiştir. Yapılan analiz sonucunda; astıma sahip olan hastalar ile olmayan hastalar, kontrollü ve kontrolsüz astım hastalarının sağlık harcamaları arasındaki farka ilişkin etki büyüklüğü ile genel etki büyüklüğünün oldukça yüksek olduğu bulunmuştur. Astım hastalığına sahip olma(ma), hastalık seviyesi ve kontrol düzeyi sağlık hizmeti kullanım düzeyi ve sağlık harcamaları üzerinde oldukça önemli bir etmendir. Astım hastalığını yönetebilmek, hastalığın sağlık sistemi ve hane halkları üzerindeki ekonomik yükünü minimize etmek, tedavide etkinliği sağlayabilmek, hastalığa yönelik hazırlanacak planı ve programları etkin bir şekilde gerçekleştirebilmek için ülke genelinde astım prevalans araştırmaları yapılması önerilmektedir.

Kaynakça

  • Aaron, S. D., Boulet, L. P., Reddel, H. K., ve Gershon, A. S. (2018). Underdiagnosis and overdiagnosis of asthma. American journal of respiratory and critical care medicine, 198(8), 1012-1020.
  • *Alefan, Q., Nawasrah, A., Almomani, B., ve Al-Issa, E. T. (2022). Direct medical cost of pediatric asthma in Jordan: A cost-of-illness retrospective cohort study. Value in Health Regional Issues, 31, 10-17.
  • *Aneeshkumar, S., ve Singh, R. B. (2018). Economic burden of asthma among patients visiting a private hospital in South India. Lung India: Official Organ of Indian Chest Society, 35(4), 312.
  • *Barbosa, J. P., Ferreira-Magalhães, M., Sá-Sousa, A., Azevedo, L. F., ve Fonseca, J. A. (2017). Cost of asthma in Portuguese adults: A population-based, cost-of-illness study. Revista Portuguesa de Pneumologia (English Edition), 23(6), 323-330.
  • Borenstein, M., Hedges, L. V., Higgins, J.P.T., Rothstein, H.R., 2009. Introduction to MetaAnalysis. John Wiley ve Sons, Ltd, Chichester, UK, UK
  • Bousquet, J., Mantzouranis, E., Cruz, A. A., Aït-Khaled, N., Baena-Cagnani, C. E., Bleecker, E. R., ... ve Zuberbier, T. (2010). Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. Journal of Allergy and Clinical Immunology, 126(5), 926-938.
  • Chastek, B., Korrer, S., Nagar, S. P., Albers, F., Yancey, S., Ortega, H., ... ve Dalal, A. A. (2016). Economic burden of illness among patients with severe asthma in a managed care setting. Journal of Managed Care ve Specialty Pharmacy, 22(7), 848-861.
  • *Chen, W., Safari, A., FitzGerald, J. M., Sin, D. D., Tavakoli, H., ve Sadatsafavi, M. (2019). Economic burden of multimorbidity in patients with severe asthma: a 20-year population-based study. Thorax, 74(12), 1113-1119.
  • Cisternas, M. G., Blanc, P. D., Yen, I. H., Katz, P. P., Earnest, G., Eisner, M. D., ... ve Yelin, E. H. (2003). A comprehensive study of the direct and indirect costs of adult asthma. Journal of allergy and clinical immunology, 111(6), 1212-1218.
  • Cleophas, J. T., ve Zwinderman, H. A. (2017). Modern meta-analysis: Review and update of methodologies. Springer International Publishing Switzerland.
  • Cohen, J. (1988). Statistical power analysis for the behavioral sciences. (2nd Edition) Hillsdale, NJ: Erlbaum.
  • Colice, G., Wu, E. Q., Birnbaum, H., Daher, M., Marynchenko, M. B., ve Varghese, S. (2006). Healthcare and workloss costs associated with patients with persistent asthma in a privately insured population. Journal of occupational and environmental medicine, 794-802.
  • Çınar, N. (2021). İyi bir sistematik derleme nasıl yazılmalı? Online Türk Sağlık Bilimleri Dergisi, 6(2), 310-314.
  • Darba, S., Safaei, N., Mahboub–Ahari, A., Nosratnejad, S., Alizadeh, G., Ameri, H., ve Yousefi, M. (2020). Direct and indirect costs associated with coronary artery (heart) disease in Tabriz, Iran. Risk Management and Healthcare Policy, 969-978.
  • *Doz, M., Chouaid, C., Com-Ruelle, L., Calvo, E., Brosa, M., Robert, J., ... ve Detournay, B. (2013). The association between asthma control, health care costs, and quality of life in France and Spain. BMC pulmonary medicine, 13, 1-10.
  • Field, A. P., ve Gillett, R. (2010). How to do a meta‐analysis. British Journal of Mathematical and Statistical Psychology, 63(3), 665-694.
  • *Finkelstein, E. A., Lau, E., Doble, B., Ong, B., ve Koh, M. S. (2021). Economic burden of asthma in Singapore. BMJ Open Respiratory Research, 8(1), e000654.
  • GBD (2019) Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 17; 396(10258):1204-1222. doi: 10.1016/S0140-6736(20)30925-9.
  • Glass, G. V., 1976. Primary, Secondary, and Meta-Analysis of Research. Educational Researcher 5, 3–8. Global Asthma Network. The global asthma report. 2018. Erişim Adresi: http://globalasthmareport.org/ resources/Global_Asthma_Report_ 2018.pdf Erişim Tarihi: 12.04.2023
  • Global Burden of Dısease, (2023). Diseases, Injuries, and Impairments. Erişim Adresi: https://www.thelancet.com/gbd/summaries Erişim Tarihi: 18. 05.2023
  • Hekking, P. P. W., Wener, R. R., Amelink, M., Zwinderman, A. H., Bouvy, M. L., ve Bel, E. H. (2015). The prevalence of severe refractory asthma. Journal of Allergy and Clinical Immunology, 135(4), 896-902.
  • Higgins, J. P., ve Thompson, S. G. (2002). Quantifying heterogeneity in a meta‐analysis. Statistics in medicine, 21(11), 1539-1558.
  • Ivanova, J. I., Bergman, R., Birnbaum, H. G., Colice, G. L., Silverman, R. A., ve McLaurin, K. (2012). Effect of asthma exacerbations on health care costs among asthmatic patients with moderate and severe persistent asthma. Journal of Allergy and Clinical Immunology, 129(5), 1229-1235.
  • Lee, L. K., Ramakrishnan, K., Safioti, G., Ariely, R., ve Schatz, M. (2020). Asthma control is associated with economic outcomes, work productivity and health-related quality of life in patients with asthma. BMJ Open Respiratory Research, 7(1), e000534.
  • *López-Tiro, J., Contreras-Contreras, A., Rodríguez-Arellano, M. E., ve Costa-Urrutia, P. (2022). Economic burden of severe asthma treatment: A real-life study. World Allergy Organization Journal, 15(7), 100662.
  • *Nagase, H., Adachi, M., Matsunaga, K., Yoshida, A., Okoba, T., Hayashi, N., ... ve Tohda, Y. (2020). Prevalence, disease burden, and treatment reality of patients with severe, uncontrolled asthma in Japan. Allergology International, 69(1), 53-60.
  • *Ng, B., Sadatsafavi, M., Safari, A., FitzGerald, J. M., ve Johnson, K. M. (2019). Direct costs of overdiagnosed asthma: a longitudinal, population-based cohort study in British Columbia, Canada. BMJ open, 9(11), e031306.
  • *Nili, M., Dwibedi, N., Adelman, M., LeMasters, T., Madhavan, S. S., ve Sambamoorthi, U. (2021). Economic burden of asthma-chronic obstructive pulmonary disease overlap among older adults in the United States. COPD: Journal of Chronic Obstructive Pulmonary Disease, 18(3), 357-366.
  • Nurmagambetov, T., Kuwahara, R., ve Garbe, P. (2018). The economic burden of asthma in the United States, 2008–2013. Annals of the American Thoracic Society, 15(3), 348-356.
  • *Nurmagambetov, T., Kuwahara, R., ve Garbe, P. (2018). The economic burden of asthma in the United States, 2008–2013. Annals of the American Thoracic Society, 15(3), 348-356.
  • *Pallegedara, A. (2018). Impacts of chronic non-communicable diseases on households’ out-of-pocket healthcare expenditures in Sri Lanka. International journal of health economics and management, 18(3), 301-319.
  • Patole, S. (Ed.). (2021). Principles and practice of systematic reviews and meta-analysis. Cham: Springer International Publishing. doi:10.1007/978-3-030-71921-0
  • *Reibman, J., Tan, L., Ambrose, C., Chung, Y., Desai, P., Llanos, J. P., ... ve Tkacz, J. (2021). Clinical and economic burden of severe asthma among US patients treated with biologic therapies. Annals of Allergy, Asthma ve Immunology, 127(3), 318-325.
  • *Roche, N., Nadif, R., Fabry-Vendrand, C., Pillot, L., Thabut, G., Teissier, C., ... ve Zins, M. (2023). Asthma burden according to treatment steps in the French population-based cohort CONSTANCES. Respiratory Medicine, 206, 107057.
  • *Sullivan, P. W., Ghushchyan, V., Navaratnam, P., Friedman, H. S., Kavati, A., Ortiz, B., ve Lanier, B. (2017). The national cost of asthma among school-aged children in the United States. Annals of allergy, asthma ve immunology, 119(3), 246-252.
  • Sullivan, S. D., Rasouliyan, L., Russo, P. A., Kamath, T., Chipps, B. E., ve TENOR Study Group. (2007). Extent, patterns, and burden of uncontrolled disease in severe or difficult‐to‐treat asthma. Allergy, 62(2), 126-133.
  • Suruki, R. Y., Daugherty, J. B., Boudiaf, N., ve Albers, F. C. (2017). The frequency of asthma exacerbations and healthcare utilization in patients with asthma from the UK and USA. BMC pulmonary medicine, 17(1), 1-11. Şen, S. ve Yıldırım, İ. (2020). CMA ile meta-analiz uygulamaları. Anı Yayıncılık.
  • The Global Asthma Report. (2022). The global asthma report 2022. The International Journal of Tuberculosis and Lung Disease, 26 (1), 1-104.
  • Vellopoulou K, Bakakos P, Loukides S, Maniadakis N, Kourlaba G. (2019). The economic burden of asthma in Greece: A cross-sectional study Appl Health Econ Health Policy. 17:629-40. doi: 10.1007/s40258-019- 00469-4. PubMed PMID: 30997609.
  • *Vellopoulou, K., Bakakos, P., Loukides, S., Maniadakis, N. ve Kourlaba, G. (2019). The economic burden of asthma in Greece: a cross-sectional study. Applied Health Economics and Health Policy, 17, 629-640.
  • WHO (2023). Asthma. Erişim Adresi: https://www.who.int/news-room/fact-sheets/detail/asthma Erişim Tarihi: 16. 05.2023.
  • Wirtz, V. J., Turpin, K., Laing, R. O., Mukiira, C. K., ve Rockers, P. C. (2018). Access to medicines for asthma, diabetes and hypertension in eight counties of Kenya. Tropical Medicine ve International Health, 23(8), 879-885.
  • Yaghoubi, M., Adibi, A., Safari, A., FitzGerald, J. M., ve Sadatsafavi, M. (2019). The projected economic and health burden of uncontrolled asthma in the United States. American journal of respiratory and critical care medicine, 200(9), 1102-1112.
Toplam 43 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Ekonomisi, Sağlık Yönetimi
Bölüm İktisadi ve İdari Bilimler
Yazarlar

Servet Alp 0000-0001-8156-2205

İsmail Ağırbaş 0000-0002-1664-5159

Yayımlanma Tarihi 29 Eylül 2025
Gönderilme Tarihi 3 Temmuz 2023
Yayımlandığı Sayı Yıl 2025 Cilt: 27 Sayı: 3

Kaynak Göster

APA Alp, S., & Ağırbaş, İ. (2025). Astım Hastalığının Küresel Ekonomik Yükü: Sistematik Derleme ve Meta Analiz Çalışması. Afyon Kocatepe Üniversitesi Sosyal Bilimler Dergisi, 27(3), 938-962. https://doi.org/10.32709/akusosbil.1322364