Biosensor Studies For The Diagnosis Of Pancreas Cancer In Early Stages

Yıl 2023, Cilt: 6 Sayı: 1, 81 - 94, 15.06.2023

Zikriye Özbek , Nurşah Gür

Öz

Pancreatic cancer is a type of cancer with a poor prognosis and high mortality rate. Pancreatic cancer, which is an aggressive type of cancer, is very difficult to detect early and is usually diagnosed in later stages. The 5-year survival rate in diagnosed patients is 6% on average. Therefore, early detection of pancreatic cancer has an important role in increasing the survival rate and reducing mortality rates as a result of early intervention. Imaging techniques such as biopsy, ultrasound, and magnetic resonance are used as traditional methods in the diagnosis of pancreatic cancer, but these techniques are expensive, take a lot of time and need to be performed and analyzed by experts in the field in order to obtain accurate and precise results. For this reason, biosensors, which are more accessible, inexpensive, can be used by everyone, and have a high probability of giving accurate results, have been suggested to be used in the diagnosis of pancreatic cancer. In this study, biosensor studies for the detection of biomarkers such as miRNA and protein, which are revealed in the presence of pancreatic cancer, are included.

Anahtar Kelimeler

Pancreatic Cancer, Pancreatic Cancer Symptoms, Biomarkers, Biosensors

Pankreas Kanserinin Erken Evrelerde Teşhisi için Yapılan Biyosensör Çalışmaları

Öz

Pankreas kanseri, kötü prognoza ve yüksek ölüm oranına sahip bir kanser türüdür. Agresif bir kanser türü olan pankreas kanserinin erken tespit edilmesi oldukça zordur ve genellikle ileriki evrelerde kesin olarak teşhis koyulmaktadır. Teşhis konulan hastalarda 5 yıllık sağkalım oranı ortalama % 6’dır. Bu yüzden, pankreas kanserinin erken teşhis edilmesi, erken müdahale sonucu sağkalım oranını arttırmada ve ölüm oranlarını azaltmada önemli bir role sahiptir. Pankreas kanserinin teşhis edilmesinde geleneksel yöntemler olarak biyopsi, ultrason, manyetik rezonans gibi görüntüleme teknikleri kullanılır ancak bu teknikler pahalı, çok zaman almakta ve doğru, kesin sonuçlar alabilmek için alanında uzman kişiler tarafından yapılması ve analiz edilmesi gerekmektedir. Bu nedenle daha kolay ulaşılabilen, ucuz, herkes tarafından kullanılabilme özelliğine sahip ve doğru sonuç verme olasılığı yüksek araçlar olan biyosensörler, pankreas kanserinin teşhisinde kullanılması önerilmiştir. Bu çalışmada pankreas kanserinin varlığında açığa çıkan miRNA, protein gibi biyobelirteçlerin tespitine yönelik biyosensör çalışmalarına yer verilmiştir.

Anahtar Kelimeler

Pankreas kanseri, Pankreas Kanseri Belirtileri, Biyobelirteçler, Biyosensörler

Kaynakça

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