Effects of Lovastatin Suplemented Diet on Laying Performance, Egg Quality, Yolk Lipid Profile and Some Serum Parameters in Laying Hens

Abstract

This study was carried out to determine the effects of lovastatin supplementation on laying performance, egg quality, yolk lipid profile and some serum parameters in Lohmann LS white commercial laying hens reared in poultry houses of Food and Livestock Application and Research Center of Ataturk University. In this experiment, Lohmann layers (n=48, 46 wks of age) were randomly divided into two groups such as control (C) fed with basal diet and treatment (L) group fed with diet including 0,0059 % of lovastatin. After one week of the adaptation period, experiment lasted for five weeks. During the experimental period, hens were fed as ad-libitum and water through nipples was available for all the times. Lovastatin supplementation increased feed consumption (FC) and feed conversion ratio (FCR). Except for yolk color, other egg quality traits were not affected by diet including 0,0059 % of lovastatin. Hens fed with treatment diet had greater triglyceride and phosphatidyl serine values than hens fed with basal diet. Differences between the groups in terms of the levels of egg yolk and serum cholesterol were not significant in present study. These differences could be attributed to short experimental period and low lovastatin added to basal diet of hens. In conclusion, further studies should be conducted to clarify the effects of lovastatin supplementation on laying performance, egg quality, yolk lipid profile and some serum parameters in laying hens fed with diets including lovastatin at different levels during long feeding period.

Keywords

• Laying hens,Lovastatin,Laying performance,Egg quality,Egg yolk lipid profile,Serum parameters

Kaynakça

1. Alberts, A.W. 1998. Discovery, biochemistry and biology of lovastatin. The American Journal of Cardiology. 62: 10-15.
2. Çakır, S. and Yalçın, S., 2004. Yumurta kolestrol düzeyine etki eden faktörler Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, 44:51-63.
3. Elkin, G.R., and Rogler, J.C., 1990. Reduction of the cholesterol content of eggs by the oral adminastration of lovastation to laying hens. Journal of Agricultural Food Chemistry, 38:1635-1641.
4. Elkin, R.G., Yan, Z., Zhong, Y., Donkin, S.S., Buhman, K.K., Story, J.A., Turek, J.J., Porter, R.E., Anderson, M., Homan, R. and Newton, R.S. 1999. Select 3-hydroxy-3- methylglutaryl-coenzyme A reductase inhibitors vary in their ability to reduce egg yolk cholesterol leves in laying hens through alteration of hepatic cholesterol biosynthesis and plasma VLDL composition. Journal of Nutrition, 129:1010-1019.
5. Hara, A. and Radin, N.S. 1978. Lipid extraction of tissues with a low-toxicity solvent. Analytical Biochemistry, 90: 420–426.
6. Hugget, C.D., Buttery, P.J. and Salter, A.M. 1993. Plasma VLDL cholesterol and egg cholesterol are resistant to change in the layinh hen. Biochemical Society Transactions, 21:147.
7. Kim, J.H., Hong, S.t., Lee, H.S., and Kim, H.J., 2004. Oral adminastration of pravastatin reduces egg cholesterol but not plasma cholesterol in laying hens. Poulrty Science, 83:1539-1543.
8. Luhman, C.M., Miller B.G. and Beitz, D., 2000. Research note: The effect of feeding lovasttatin and colestipol on production and cholesterol content of eggs. Poultry Science, 69:852-855.

9. Macala, L.J., Yu, R.K. and Ando, S. 1983. Analysis of brain lipids by high performance thin-layer chromatography and densitometry. The Journal of Lipid Research, 24: 1243- 1250.
10. Mori, A.V., Mendonca, C.X., and Watanabe, C., 2000. Effect of cholestyramine and lovastatin upon plasma lipids and egg yolk cholesterol leves of laying hens. Brazilian Journal of Veterinary Animal Science, 37: 84-89.
11. Mori, A.V., Mendonca, C.X., and Santos, C.O.F., 1999. Effect of dietary lipid-lowering drugs upon plasma lipids and egg yolk cholesterol levels of laying hens. Journal of Agricultural and Food Chemistry, 47:4731-4735.
12. Naber, C.E.,1976. The cholesterol problem, the egg and lipid metabolism in the laying hen. Poultry Science, 55: 14-30.
13. SPSS, 1996. Statistical Packages for the Social Sciences: SPSS for Windows release 10.01. SPSS Inc., Chicago, 1996.