Karbotiyoamidin Sübstitüye Benzimidazol Bileşiklerinin Sentezi ve Biyolojik Aktivitelerinin İncelenmesi

Öz

Yapılarında bir oksijen atomu ile birlikte nitrojen içeren heterosiklik bileşikler, çeşitli biyolojik uygulamaları nedeniyle önemli bir tıbbi kimya bileşikleri sınıfıdır. Benzimidazoller de bu grupta yer alıp, halka yapısında farklı yapıda iki azot (N) atomu taşıyan heterosiklik bir aromatik organik bileşiktir. Yapılan bu çalışmada, sentezlenen benzimidazol türevlerinin (1-5) antiüreaz ve antioksidan aktiviteleri spektrofotometrik metotlarla incelendi. Antioksidan aktivitesinin kanıtı bizlere vücutta oluşabilecek hastalıklara karşı savunma mekanizmasının var olduğunu açıkça göstermektedir. Sentezlenen tüm benzimidazol bileşikleri antiüreaz ve antioksidan aktivite gösterdi. Üreaz inhibisyon aktivitesi gösteren en güçlü bileşik 2 numaralı, en az aktif bileşik ise 4 numaralı bileşiktir. Tüm bileşikler tiyoüreden daha yüksek aktivite gösterdi. En yüksek antioksidan aktivitesine sahip bileşik 5 numaralı bileşik, en düşük antioksidan aktivitesine sahip bileşik ise 4 numaralı bileşikler olarak belirlendi.

Anahtar Kelimeler

• ABTS ve DPPH aktivitesi
• Antiüreaz aktivite
• Antioksidan aktivite
• Benzimidazol

Synthesis of Carbothioamide Substituted Benzimidazole Compounds and Investigation of Biological Activities

Öz

Heterocyclic compounds containing nitrogen along with an oxygen atom in their structure are a major class of medicinal chemistry compounds due to their diverse biological applications. Benzimidazoles is also a heterocyclic aromatic organic compound in this group, carrying two different nitrogen (N) atoms in the ring structure. In this study, the antiurease and antioxidant activities of the synthesized benzimidazole derivatives (1-5) were investigated by spectrophotometric methods. Evidence of antioxidant activity clearly shows us that there is a defense mechanism against diseases that may occur in the body. All synthesized benzimidazole compounds showed antiurease and antioxidant activity. The most potent compound showing urease inhibition activity is number 2, and the least active compound is compound number 4. All compounds showed higher activity than thiourea. The compound with the highest antioxidant activity was determined as compound number 5, and the compound with the lowest antioxidant activity was determined as compound number 4.

Anahtar Kelimeler

• ABTS and DPPH activity
• Antiurease activity
• Antioxidant activity
• Benzimidazole

Kaynakça

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