Optimization Studies of Mg/Al-NO3 Layered Double Hydroxide Nanoparticles by Hydrothermal Treatment

Öz

Layered Double Hydroxides based nanoparticles offer significant advantages in biological applications with high biocompatibility and low cytotoxicity. In this study, nanoparticles (nMg/Al-NO3-LDH) were synthesized by the co-precipitation method and synthesis optimization of the nanoparticles was carried out by hydrothermal treatment. The effect of hydrothermal treatment on Z-average and surface charge was evaluated. Experiments were performed at 80˚C and 100˚C during in the range of 2-48 h by using different stirring rates (250, 1000, and 1500 rpm) and without stirring. Dynamic Light Scattering (DLS) was used to assess the particle size (nm), polydispersity index (PDI), and zeta potential (mV) of the nanoparticles. The chemical structure of nanoparticles was characterized by Fourier Transform Infrared spectrometry (FTIR). As a result, nanoparticles with an optimum particle size of 86.87 nm, a PDI of 0.132 and a zeta potential (mV) of 44.4±8.74 were obtained at 80˚C, 48h and 250 rpm. The data showed that Mg/Al-NO3-LDH nanoparticles have suitable physical properties for biological applications.

Anahtar Kelimeler

• Layered double hydroxide nanoparticles
• Hydrothermal treatment
• Particle size optimization
• Inorganic materials

Mg/Al-NO3 Çift Tabakalı Hidroksit Nanopartiküllerinin Hidrotermal İşlem İle Optimizasyonu Çalışmaları

Öz

Çift Tabakalı Hidroksitler yüksek biyouyumluluk ve düşük sitotoksisite ile biyolojik uygulamalarda önemli avantajlar sunar. Bu çalışmada nanopartiküller (nMg/Al-NO3-LDH) birlikte çöktürme yöntemiyle sentezlendi ve nanopartiküllerin sentez optimizasyonu hidrotermal işlem altında gerçekleştirildi. Hidrotermal işlemin partikül boyutu ve yüzey yükü üzerindeki etkisi değerlendirildi. Deneyler 80˚C ve 100˚C'de, 2-48 saat aralığında ve çeşitli karıştırma hızlarında 250, 1000, 1500 rpm gerçekleştirildi. Nanopartiküllerin partikül boyutu (nm), polidispersite indeksi (PDI) ve zeta potansiyel (mV) değerleri Dinamik Işık Saçılımı (DLS) ile saptandı. Nanopartiküllerin kimyasal yapısı Fourier Dönüşümü Kızılötesi spektrometresi (FTIR) ile karakterize edildi. Sonuç olarak, 80˚C, 48 saat ve 250 rpm'de optimum partikül boyutu 86.87 nm, polidispersite indeksi (PDI) 0.132 ve zeta potansiyeli (mV) 44.4±8.74 olan nanopartiküller elde edildi. Veriler, biyolojik uygulamalarda kullanıma yönelik Mg/Al-NO3-LDH nanopartiküllerinin uygun fiziksel özelliklere sahip olduğunu gösterdi.

Anahtar Kelimeler

• Çift tabakalı hidroksit nanopartiküller
• Hidrotermal işlem
• Partikül boyutu optimizasyonu
• İnorganik malzemeler

Kaynakça

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