B-12 Vitamin And Infertility

Abstract

Infertility is one of the important health problems in the world. The etiology of all infertility cases is not known properly. IVF techniques are applied in unexplained infertility cases, but these techniques are invasive, expensive, painful, but not always successful. Some investigators declare that B 12 vitamin deficiency plays a role in infertility etiology, and success is achieved with the easy and cheap theraphy. The relationship between B 12 vitamin and infertility is assessed in this article.

Keywords

• Cobalamin, vitamin B12, folic acid, infertility, nutrition

B-12 Vitamini ve İnfertilite

Öz

Özet: Dünyada infertilite önemli bir problemdir. Her infertilite vakasının etyolojisi tam olarak bilinememektedir. Açıklanamayan infertilite vakalarında pahalı, invaziv, ağrılı bir metod olan ÜYT (Üremeye Yardımcı Teknikler) uygulanmaktadır ve hepsinde başarı sağlanamamaktadır.B 12 eksikliğinin infertilitede rolü olduğu ve tedavisi ile ucuz, kolay şekilde başarı elde edildiği belirtilmektedir. Buderlemede B 12 ve infertilite ilişkisi incelenecektir.

Anahtar Kelimeler

• Kobalamin,B 12 vitamini,folik asit,infertilite,beslenme

Kaynakça

1. 1-Stabler S P, Allen R H, Savage D G, Lindenbaum J. Clinical spectrum and diagnosis and cobalamin deficiency. Blood 1990;76: 871-881. 2-Nelen WL, Blom HJ, Steegers EA, den Heijer M, Thomas
2. CM,Eskes TK. Homocysteine and folate levels as risk factors for recurrent early pregnancy loss. Obstet Gynecol 2000; 95: 519-24.
3. 3-Ray JG, Laskin CA. Folic acid and homocysteine metabolic defects and risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: a systematic review. Placenta 1999; 20: 519-29.
4. 4-Nelen WL,Bloom HJ, Steegers EA, den Heijer M, Eskes TK. Hyperhomocysteinemia and recurrent early pregnancy loss: a metaanalysis. Fertil Steril 2000; 74: 1196-99. 5-Haggarty P, McCallum H, Andrews K, Duthie S, McNeill G, Templeton A, Haites N, Campbell D, Bhattacharya S, Effect of B vitamins and genetics on success of in-vitro fertilization: prospective cohort study. Lancet 2006; 367:1513-19.
5. 6- Mitchell LM, Robinson JJ, Watt RG, McEvoy TG, Ashworth CJ, Rooke JA, Dwyer CM. Effects of cobalt/vitamin B12 status in ewes on ovum development and lamb viability at birth. Reprod Fertil Dev. 2007;19(4):553-62.
6. 7- Gulden KD, Pernicious anemia, vitiligo, and infertility. J Am Board Fam Pract. 1990;3(3):217-20.
7. 8- Çelebi S, Nalcacı M, Küçükkaya R ve ark. Kobalamin eksikliğine bağlı olarak ortaya çıkan infertilite: Üç olgu sunumu. XXVIII Ulusal Hematoloji Kongresi, İzmir: 2-4 Kasım 2000:178-202. 9- Asma S, Boğa C, Özdoğu H. Vitamin B 12 tedavisiyle gebelikleri gerçekleşen 2 infertil olgunun sunusu. XXX . Ulusal Hematoloji Kongresi, Özet kitabı, Sayfa 163, bildiri özet no 286, poster no 202, 2002.
8. 10-Cetin I, Berti C, Calabrese S, Role of micronutrients in the periconceptional period. Human Reprod Update, 2010;16(1): 8011-Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. Iron intake and risk of ovulatory infertility. Obstet Gynecol 2006;108:1145-1152.

9. 12-Ebisch IMW,Thomas CMG, Peters WHM, Braat DDM, Steegers-Theunissen RPM. The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Hum Reprod Update 2007; 13: 163-174.
10. 13-Ronnenberg AG,Venners SA, Xu X, Chen C, Wang L, Guang W, Huang A, Wang X.Preconception B vitamin and homocysteine status, conception,and early pregnancy loss. Am J Epidemiol 2007;2-9(doi: 10.1093/aje/kwm078).
11. 14- Murphy LE, Mills JL, Molloy AM, Qian C, Carter TC, Strevens H, Wide-Stevensson D, Giwercman A, Levine rj. Folate and vitamin B12 in idiopatic male infertility.Assian J Androl. 2011; 13(6):856-861 (doi: 10.1038/aja.2011.96).
12. Yazışma Adresi / Correspondence: Ayşe Filiz Yavuz AVŞAR Yıldırım Beyazıt Üniversitesi Tıp Fakültesi, Kadın Hast ve Doğum Anabilim Dalı, Atatürk Eğ. Araş. Hast. Bilkent, Lodumlu Mevki, Eskişehir Yolu, Ankara. e-posta: [e-mail]