Leukocyte Count as Chronic Inflammation Markers in Type 2 Diabetes Patients

Öz

Objectives: Epidemiological studies have revealed an association between higher total peripheral white blood cells (WBC) count and Type 2 Diabetes Mellitus (T2DM). However, the association has not been systematically investigated. The aim of this study was to compare peripheral leukocyte count and biochemical test results in diabetic and non–diabetic patients.
Materials and Methods: The study was conducted among the patients had been followed by Family Medicine Outpatient Clinics of Dışkapı Yıldırım Beyazıt Training and Research Hospital between 02.02.2015-30.09.2015. Patients anthropometric measurements, complete blood cell count and biochemical tests’ results were recorded and these values were compared between two groups (T2DM(+) and T2DM(-)).
Results: A total of 286 patients (mean age: 58.7±10.5 years) were enrolled. There were no differences in age and sex distribution between T2DM(+) (n=108) and T2DM (-) (n=178) groups. In T2DM(+) group, leukocyte count was found to be higher than T2DM(-) group (7.73 × 103/ml; 7.17 × 103/ml; p=0.001). Waist circumference, body mass index, fasting blood glucose, alanine amino transferase and triglycerides levels were also found to significantly higher in T2DM(+) group. Conversly, high density lipoprotein and low-density lipoprotein levels were found to be significantly lower in T2DM(+) group. 
Conclusion: Leukocyte count, even within normal range, was higher in T2DM patients compared to non-diabetic individuals. Our results support the role of chronic inflammation in T2DM. There is a need for comprehensive studies to explain the role of inflammation in diabetes.

Anahtar Kelimeler

• Inflammation,diabetes,leukocyte count

Tip 2 Diyabet Hastalarında Kronik İnflamasyon Belirteci Olarak Lökosit Sayımı

Öz

Amaç: Epidemiyolojik araştırmalar periferik kandaki lökosit sayısı ile Tip 2 Diyabetes Mellitus (T2DM) arasında ilişki bulunduğunu göstermesine rağmen bu ilişki sistematik olarak incelenmemiştir. Bu çalışmada, T2DM tanısı olan hastaların (T2DM(+)) lökosit sayımı ve biyokimya tetkik sonuçlarının diyabeti olmayan hastaların (T2DM(-)) sonuçlarıyla karşılaştırılması amaçlanmıştır.

Materyal ve Metot: Çalışmaya; 02.02.2015-30.09.2015 tarihleri arasında Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi Aile Hekimliği Poliklinikleri’ne başvuran hastalar alınmıştır. Hastaların antropometrik ölçümleri, tam kan sayımı ve biyokimyasal testlerinin sonuçları kaydedilmiştir ve bu değerler T2DM(+) ile T2DM(-) grupları arasında karşılaştırılmıştır.

Bulgular: Çalışmaya dâhil edilen 286 hastanın yaş ortalaması 58,7±10,5 yıl olarak saptandı. T2DM(+) (n=108) ve T2DM(-) (n=178) gruplarının yaş ve cinsiyet dağılımları arasında fark yoktu. T2DM(+) grubun ortalama lökosit sayısının T2DM(-) grubundan yüksek olduğu saptandı (7,73 × 103/ml; 7,17 × 103/ml; p=0,001). T2DM(+) grubun bel çevresi, vücut kitle indeksi (VKİ), açlık kan şekeri (AKŞ), alanin aminotransferaz (ALT) ve trigliserid değerleri T2DM(-) grubuna göre anlamlı olarak yüksek olduğu, düşük yoğunluklu kolesterol (LDL) ve yüksek yoğunluklu kolesterol (HDL) değerlerinin ise anlamlı olarak daha düşük olduğu bulundu. 

Sonuç: Lökosit sayısı normal sınırlar içerisinde dahi T2DM hastalarında diyabeti olmayan bireylerden daha yüksektir. Bizim sonuçlarımız kronik inflamasyonun Tip 2 diyabetteki rolünü desteklemektedir. İnflamasyonun diyabetteki rolünü açıklayacak daha kapsamlı çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• İnflamasyon,diyabet,lökosit sayımı

Kaynakça

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