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Role and Benef its of Insulin Analogues in the Treatment of Diabetes Mellitus

Yıl 2012, Cilt 12, Sayı 1, 22 - 31, 01.01.2012

Öz

Diabetes mellitus is an increasing health problem in the world and our country. Medical nutrition, diet, exercise, patient education and medical treatment constitute major solution methods for this problem. Insulin has a special place among choices of medical treatment. In this article, insulin analogues in treatment of diabetes mellitus were reviewed. When glycemic control, hypoglycemia side effect and patient compliance to treatment are considered, previous studies have shown that analogue insulins should be preferred to human insulin. Insulin analogues have an important role in medical treatment of diabetes mellitus.

Kaynakça

  • 1. United Kingdom Prospective Diabetes Study Group Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet,1998, 352:854–865
  • 2. United Kingdom Prospective Diabetes Study Group Intensive blood-glucose control with sulphonylureas or insülin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet,1998, 352:837–853
  • 3. Ohkubo Y, Kishikawa H, Araki E et al. Intensive insülin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulindependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract, 1995, 28:103–117
  • 4. Stratton IM, Adler AI, Neil HA et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ,2000, 321:405–412
  • 5. Gaede P, Vedel P, Larsen N et al. Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med ,2003, 348:383–393
  • 6. Genuth S, Eastman R, Kahn R et al. Implications of the United kingdom prospective diabetes study. Diabetes Care,2003, 26:S28–S32
  • 7. Chiasson JL. Acarbose for the prevention of diabetes, hypertension, and cardiovascular disease in subjects with impaired glucose tolerance: the Study to Prevent Non-Insulin-Dependent Diabetes Mellitus (STOP-NIDDM) Trial. Endocr Pract,2006, 12:25–30
  • 8. Selvin E, Wattanakit K, Steffes MW, Coresh J, Sharrett AR. HbA1c and peripheral arterial disease in diabetes: the atherosclerosis risk in communities study. Diabetes Care,2006, 29:877–882
  • 9. Kirkman MS, McCarren M, Shah J, Duckworth W, Abraira C. The association between metabolic control and prevalent macrovascular disease in Type 2 diabetes: the VA Cooperative Study in diabetes. J Diabetes Complications,2006, 20:75–80
  • 10. Martin S, Schneider B, Heinemann L et al. Selfmonitoring of blood glucose in type 2 diabetes and long-term outcome: an epidemiological cohort study. Diabetologia,2006, 49:271–278
  • 11. American Diabetes Association. Standards of medical care for patients with diabetes mellitus. Diabetes Care,2003, 26:S33–S50
  • 12. IDF Global Guideline for Type 2 Diabetes, 2011.
  • 13. Satman İ et al. TURDEP II results. Turkish Endocrinology and Metabolism Congress 2010
  • 14. İlkova İ et al. IDMPS Turkey 3rd wave results – The profile of Type 2 DM patients and the treatment methods. National Diabetes Congress 2010
  • 15. Barnett AH. A review of basal insulins. Diabet. Med,2003, 20, 873–885
  • 16. Lepore M. et al. Pharmacokinetics and Pharmacodynamics of Subcutaneous Injection of Long-Acting Human Insulin Analog Glargine, NPH Insulin, and Ultralente Human Insulin and Continuous Subcutaneous Infusion of Insulin Lispro Diabetes,2000, 49:2142–2148
  • 17. Ratner RE. et al. Less Hypoglycemia With Insulin Glargine in Intensive Insulin Therapy for Type 1 Diabetes Diabetes Care,2000, 23:639–643
  • 18. Ashwell S.G. et al. Improved Glycaemic Control with Insulin Glargine plus Insulin Lispro: A multicentre, Randomized, Cross-over Trial in People with Type 1 Diabetes. Diabetic Medicine,2006, 23, 285-292
  • 19. Home P.D. et al. A randomized multicentre trial of insulin glargine compared with NPH insulin in people with type 1 diabetes Diabetes Metab Res Rev 2005; 21: 545–553.
  • 20. Raskin P. et al. A 16-Week Comparison of the Novel Insulin Analog Insulin Glargine (HOE 901) and NPH Human Insulin Used With Insulin Lispro in Patients With Type 1 Diabetes Diabetes Care,2000, 23:1666–1671
  • 21. Benedetti M. et al. A One Year, Randomised, Multicentre Trial Comparing Insulin Glargine with NPH Insulin in Combination with Oral Agents in Patients with Type 2 Diabetes. Horm. Metab Res 2003;35: 189-196
  • 22. Herwig J. et al. Glycaemic Control and Hypoglycaemia in Children, Adolescents and Young Adults with Unstable Type 1 Diabetes Mellitus Treated with Insulin Glargine or Intermediate-acting Insulin Journal of Pediatrie Endocrinology & Metabolisrn,2007, 20: 517-525
  • 23. Mullins P. et al. Negative Binominal Meta-Regression Analysis of Combned Glycosylated Hemoglobin and Hypoglycaemia Outcomes Across Eleven Phase III and IV Studies of Insulin Glargine Compared with NPH Insulin in Type 1 and Type 2 DM. Clinical Therapeutics Volume 29, Number 8, 2007; 1607-1619
  • 24. White NH. et al. Comparison of Glycaemic Variability Associated With Insulin Glargine and Intermediate-Acting Insulin when used as the Basal Componennt of Multiple Daily Injections for Adolescents With Type 1 Diabetes. Diabetes Care,2009, 32:387-393
  • 25. Fritsche A et al. Glimepiride Combined with Morning Insulin Glargine, Bedtime Neutral Protamine Hagedorn Insulin, or Bedtime Insulin Glargine in Patients with Type 2 Diabetes. Ann Intern Med. 2003;138:952-959.
  • 26. Tsai ST et al. First Insulinization with Basal Insulin in Patients with Type 2 Diabetes in a Real-world Setting in Asia. Journal of Diabetes 3 ,2011, 208-216
  • 27. Chase HP. et al. Insulin Glargine Versus IntermediateActing Insulin as the Basal Component of Multiple Daily Injection Regimens for Adolescents with Type 1 Diabetes Mellitus. 10.1016/j.jpeds.2008.04.063
  • 28. Pan CY. et al. Insulin glargine versus NPH insulin therapy in Asian Type 2 diabetes patients Diabetes Research and Clinical Practice 76 ,2007, 111–118
  • 29. Riddle MC. et al. The Treat-to-Target Trial Randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients. Diabetes Care,2003, 26:3080–3086
  • 30. Home P.D. et al. Meta-analysis of individual patient data to assess the risk of hypoglycaemia in people with type 2 diabetes using NPH insulin or insulin glargine. Diabetes, Obesity and Metabolism ,2010, 12:772-9.
  • 31. Linn T. et al. Nocturnal Glucose Metabolism after Bedtime Injection of Insulin Glargine or Neutral Protamine Hagedorn Insulin in Patients with Type 2 Diabetes. J Clin Endocrinol Metab,2008, 93: 3839–3846
  • 32. Bolli G.B. et al. Lower fasting blood glucose, glucose variability and nocturnal hypoglycaemia with glargine vs NPH basal insulin in subjects with Type 1 diabetes. Nutrition, Metabolism & Cardiovascular Diseases ,2009, 19: 571-579
  • 33. Eliaschewitz F.G. et al. Therapy in Type 2 Diabetes: Insulin Glargine vs. NPH Insulin Both in Combination with Glimepiride. Archives of Medical Research,2006, 37: 495–501
  • 34. Witthaus E. et al. Treatment satisfaction and psychological well-being with insulin glargine compared with NPH in patients with Type 1 diabetes. Diabetic Medicine,2001, 18: 619-625
  • 35. Bradley C, Gilbride CJ. Improving treatment satisfaction and other patient-reported outcomes in people with type 2 diabetes: the role of once-daily insulin glargine. Diabetes Obes Metab. 2008, Jul;10 Suppl 2:50-65
  • 36. Schreiber S.A., Russmann A. Long-term efficacy of insülin glargine therapy with an educational programme in type 1 diabetes patients in clinical practice. Current Medical Research and Opinion, 2007, Vol. 23, No. 123131–3136
  • 37. Gordon J et al. A comparison of intermediate and longacting insulins in people with type 2 diabetes starting insulin: an observational database study. Int J Clin Pract, 2010, 64, 12, 1609–1618
  • 38. Rhoads G. et al. Comparison of Incidence of Acute Myocardial Infarction in Patients With Type 2 Diabetes Mellitus Following Initiation of Neutral Protamine Hagedorn Insulin Versus Insulin Glargine. Am J Cardiol, 2009;104:910 –916
  • 39. Kurtzhals P. Engineering predictability and protraction in a basal insulin analog: the pharmacology of insulin detemir. Int J Obesity, 2004; 28 Suppl. 2: S23-8
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  • 41. Plank J, Bodenlenz M, Sinner F, et al. A double-blind, randomized, dose-response study investigating the pharmacodynamic and pharmacokinetic properties of the long-acting insulin analog detemir. Diabetes Care ,2005; 28: 1107-12
  • 42. Heise T, Nosek I, Rønn BB, et al. Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetes. diabetes. Diabetes ,2004; 53: 1614-20
  • 43. Hermansen K. et al. Insulin analogues (insulin detemir and insulin aspart) versus traditional human insulins (NPH insulin and regular human insulin) in basal-bolus therapy for patients with Type 1 diabetes. Diabetologia, 2004; 47:622–629
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  • 64. Heller SR, Colagiuri S, Vaaler S, et al. Hypoglycaemia with insulin aspart: a doubleblind,randomised, crossover trial in subjects with Type 1 diabetes. Diabet Med 2004; 21:769–775.
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İnsülin Analoglarının Diyabetes Mellitus Tedavisindeki Rolü ve Faydaları

Yıl 2012, Cilt 12, Sayı 1, 22 - 31, 01.01.2012

Öz

Diyabetes Mellitus (DM) ülkemizde ve dünyada giderek artan bir sağlık problemidir. Tıbbi beslenme, diyet, egzersiz, hasta eğitimi ve medikal tedavi bu problemin çözüm yöntemleridir. Medikal tedavi seçenekleri içinde insülin tedavisi özel bir yer tutmaktadır. Bu yazıda diyabetes mellitus tedavisinde insülin analogları ele alınmıştır. Glisemik kontrol, hipoglisemi yan etkisi, tedavi uyumu kriter olarak alınırsa, İnsan insülini ile insülin analogları karşılaştırıldığında analog insülinlerin tercih edilmesi gerektiği yapılan çalışmalardan anlaşılmaktadır. İnsülin analogları diyabetes mellitusun medikal tedavisinde önemli bir yere sahiptir.

Kaynakça

  • 1. United Kingdom Prospective Diabetes Study Group Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet,1998, 352:854–865
  • 2. United Kingdom Prospective Diabetes Study Group Intensive blood-glucose control with sulphonylureas or insülin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet,1998, 352:837–853
  • 3. Ohkubo Y, Kishikawa H, Araki E et al. Intensive insülin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulindependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract, 1995, 28:103–117
  • 4. Stratton IM, Adler AI, Neil HA et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ,2000, 321:405–412
  • 5. Gaede P, Vedel P, Larsen N et al. Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med ,2003, 348:383–393
  • 6. Genuth S, Eastman R, Kahn R et al. Implications of the United kingdom prospective diabetes study. Diabetes Care,2003, 26:S28–S32
  • 7. Chiasson JL. Acarbose for the prevention of diabetes, hypertension, and cardiovascular disease in subjects with impaired glucose tolerance: the Study to Prevent Non-Insulin-Dependent Diabetes Mellitus (STOP-NIDDM) Trial. Endocr Pract,2006, 12:25–30
  • 8. Selvin E, Wattanakit K, Steffes MW, Coresh J, Sharrett AR. HbA1c and peripheral arterial disease in diabetes: the atherosclerosis risk in communities study. Diabetes Care,2006, 29:877–882
  • 9. Kirkman MS, McCarren M, Shah J, Duckworth W, Abraira C. The association between metabolic control and prevalent macrovascular disease in Type 2 diabetes: the VA Cooperative Study in diabetes. J Diabetes Complications,2006, 20:75–80
  • 10. Martin S, Schneider B, Heinemann L et al. Selfmonitoring of blood glucose in type 2 diabetes and long-term outcome: an epidemiological cohort study. Diabetologia,2006, 49:271–278
  • 11. American Diabetes Association. Standards of medical care for patients with diabetes mellitus. Diabetes Care,2003, 26:S33–S50
  • 12. IDF Global Guideline for Type 2 Diabetes, 2011.
  • 13. Satman İ et al. TURDEP II results. Turkish Endocrinology and Metabolism Congress 2010
  • 14. İlkova İ et al. IDMPS Turkey 3rd wave results – The profile of Type 2 DM patients and the treatment methods. National Diabetes Congress 2010
  • 15. Barnett AH. A review of basal insulins. Diabet. Med,2003, 20, 873–885
  • 16. Lepore M. et al. Pharmacokinetics and Pharmacodynamics of Subcutaneous Injection of Long-Acting Human Insulin Analog Glargine, NPH Insulin, and Ultralente Human Insulin and Continuous Subcutaneous Infusion of Insulin Lispro Diabetes,2000, 49:2142–2148
  • 17. Ratner RE. et al. Less Hypoglycemia With Insulin Glargine in Intensive Insulin Therapy for Type 1 Diabetes Diabetes Care,2000, 23:639–643
  • 18. Ashwell S.G. et al. Improved Glycaemic Control with Insulin Glargine plus Insulin Lispro: A multicentre, Randomized, Cross-over Trial in People with Type 1 Diabetes. Diabetic Medicine,2006, 23, 285-292
  • 19. Home P.D. et al. A randomized multicentre trial of insulin glargine compared with NPH insulin in people with type 1 diabetes Diabetes Metab Res Rev 2005; 21: 545–553.
  • 20. Raskin P. et al. A 16-Week Comparison of the Novel Insulin Analog Insulin Glargine (HOE 901) and NPH Human Insulin Used With Insulin Lispro in Patients With Type 1 Diabetes Diabetes Care,2000, 23:1666–1671
  • 21. Benedetti M. et al. A One Year, Randomised, Multicentre Trial Comparing Insulin Glargine with NPH Insulin in Combination with Oral Agents in Patients with Type 2 Diabetes. Horm. Metab Res 2003;35: 189-196
  • 22. Herwig J. et al. Glycaemic Control and Hypoglycaemia in Children, Adolescents and Young Adults with Unstable Type 1 Diabetes Mellitus Treated with Insulin Glargine or Intermediate-acting Insulin Journal of Pediatrie Endocrinology & Metabolisrn,2007, 20: 517-525
  • 23. Mullins P. et al. Negative Binominal Meta-Regression Analysis of Combned Glycosylated Hemoglobin and Hypoglycaemia Outcomes Across Eleven Phase III and IV Studies of Insulin Glargine Compared with NPH Insulin in Type 1 and Type 2 DM. Clinical Therapeutics Volume 29, Number 8, 2007; 1607-1619
  • 24. White NH. et al. Comparison of Glycaemic Variability Associated With Insulin Glargine and Intermediate-Acting Insulin when used as the Basal Componennt of Multiple Daily Injections for Adolescents With Type 1 Diabetes. Diabetes Care,2009, 32:387-393
  • 25. Fritsche A et al. Glimepiride Combined with Morning Insulin Glargine, Bedtime Neutral Protamine Hagedorn Insulin, or Bedtime Insulin Glargine in Patients with Type 2 Diabetes. Ann Intern Med. 2003;138:952-959.
  • 26. Tsai ST et al. First Insulinization with Basal Insulin in Patients with Type 2 Diabetes in a Real-world Setting in Asia. Journal of Diabetes 3 ,2011, 208-216
  • 27. Chase HP. et al. Insulin Glargine Versus IntermediateActing Insulin as the Basal Component of Multiple Daily Injection Regimens for Adolescents with Type 1 Diabetes Mellitus. 10.1016/j.jpeds.2008.04.063
  • 28. Pan CY. et al. Insulin glargine versus NPH insulin therapy in Asian Type 2 diabetes patients Diabetes Research and Clinical Practice 76 ,2007, 111–118
  • 29. Riddle MC. et al. The Treat-to-Target Trial Randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients. Diabetes Care,2003, 26:3080–3086
  • 30. Home P.D. et al. Meta-analysis of individual patient data to assess the risk of hypoglycaemia in people with type 2 diabetes using NPH insulin or insulin glargine. Diabetes, Obesity and Metabolism ,2010, 12:772-9.
  • 31. Linn T. et al. Nocturnal Glucose Metabolism after Bedtime Injection of Insulin Glargine or Neutral Protamine Hagedorn Insulin in Patients with Type 2 Diabetes. J Clin Endocrinol Metab,2008, 93: 3839–3846
  • 32. Bolli G.B. et al. Lower fasting blood glucose, glucose variability and nocturnal hypoglycaemia with glargine vs NPH basal insulin in subjects with Type 1 diabetes. Nutrition, Metabolism & Cardiovascular Diseases ,2009, 19: 571-579
  • 33. Eliaschewitz F.G. et al. Therapy in Type 2 Diabetes: Insulin Glargine vs. NPH Insulin Both in Combination with Glimepiride. Archives of Medical Research,2006, 37: 495–501
  • 34. Witthaus E. et al. Treatment satisfaction and psychological well-being with insulin glargine compared with NPH in patients with Type 1 diabetes. Diabetic Medicine,2001, 18: 619-625
  • 35. Bradley C, Gilbride CJ. Improving treatment satisfaction and other patient-reported outcomes in people with type 2 diabetes: the role of once-daily insulin glargine. Diabetes Obes Metab. 2008, Jul;10 Suppl 2:50-65
  • 36. Schreiber S.A., Russmann A. Long-term efficacy of insülin glargine therapy with an educational programme in type 1 diabetes patients in clinical practice. Current Medical Research and Opinion, 2007, Vol. 23, No. 123131–3136
  • 37. Gordon J et al. A comparison of intermediate and longacting insulins in people with type 2 diabetes starting insulin: an observational database study. Int J Clin Pract, 2010, 64, 12, 1609–1618
  • 38. Rhoads G. et al. Comparison of Incidence of Acute Myocardial Infarction in Patients With Type 2 Diabetes Mellitus Following Initiation of Neutral Protamine Hagedorn Insulin Versus Insulin Glargine. Am J Cardiol, 2009;104:910 –916
  • 39. Kurtzhals P. Engineering predictability and protraction in a basal insulin analog: the pharmacology of insulin detemir. Int J Obesity, 2004; 28 Suppl. 2: S23-8
  • 40. Hirsch IB. Insulin analogues. New Engl J Med, 2005; 352: 174-83
  • 41. Plank J, Bodenlenz M, Sinner F, et al. A double-blind, randomized, dose-response study investigating the pharmacodynamic and pharmacokinetic properties of the long-acting insulin analog detemir. Diabetes Care ,2005; 28: 1107-12
  • 42. Heise T, Nosek I, Rønn BB, et al. Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetes. diabetes. Diabetes ,2004; 53: 1614-20
  • 43. Hermansen K. et al. Insulin analogues (insulin detemir and insulin aspart) versus traditional human insulins (NPH insulin and regular human insulin) in basal-bolus therapy for patients with Type 1 diabetes. Diabetologia, 2004; 47:622–629
  • 44. Dornhorst A, Lüddeke HJ, Sreenan S, et al. Safety and efficacy of insulin detemir in clinical practice: 14-week follow-up data from type 1 and type 2 diabetes patients in the PREDICTIVE European cohort. Int J Clin Pract 2007; 61: 523 -8
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Ayrıntılar

Birincil Dil Türkçe
Konular Fen
Bölüm Derlemeler
Yazarlar

Bekir ÇAKIR Bu kişi benim

Yayımlanma Tarihi 1 Ocak 2012
Yayınlandığı Sayı Yıl 2012, Cilt 12, Sayı 1

Kaynak Göster

Bibtex @araştırma makalesi { amj21436, journal = {Ankara Medical Journal}, eissn = {2148-4570}, address = {}, publisher = {Ankara Yıldırım Beyazıt Üniversitesi}, year = {2012}, volume = {12}, number = {1}, pages = {22 - 31}, title = {İnsülin Analoglarının Diyabetes Mellitus Tedavisindeki Rolü ve Faydaları}, key = {cite}, author = {Çakır, Bekir} }
APA Çakır, B. (2012). İnsülin Analoglarının Diyabetes Mellitus Tedavisindeki Rolü ve Faydaları . Ankara Medical Journal , 12 (1) , 22-31 . Retrieved from https://dergipark.org.tr/tr/pub/amj/issue/1741/21436
MLA Çakır, B. "İnsülin Analoglarının Diyabetes Mellitus Tedavisindeki Rolü ve Faydaları" . Ankara Medical Journal 12 (2012 ): 22-31 <https://dergipark.org.tr/tr/pub/amj/issue/1741/21436>
Chicago Çakır, B. "İnsülin Analoglarının Diyabetes Mellitus Tedavisindeki Rolü ve Faydaları". Ankara Medical Journal 12 (2012 ): 22-31
RIS TY - JOUR T1 - İnsülin Analoglarının Diyabetes Mellitus Tedavisindeki Rolü ve Faydaları AU - BekirÇakır Y1 - 2012 PY - 2012 N1 - DO - T2 - Ankara Medical Journal JF - Journal JO - JOR SP - 22 EP - 31 VL - 12 IS - 1 SN - -2148-4570 M3 - UR - Y2 - 2022 ER -
EndNote %0 Ankara Medical Journal İnsülin Analoglarının Diyabetes Mellitus Tedavisindeki Rolü ve Faydaları %A Bekir Çakır %T İnsülin Analoglarının Diyabetes Mellitus Tedavisindeki Rolü ve Faydaları %D 2012 %J Ankara Medical Journal %P -2148-4570 %V 12 %N 1 %R %U
ISNAD Çakır, Bekir . "İnsülin Analoglarının Diyabetes Mellitus Tedavisindeki Rolü ve Faydaları". Ankara Medical Journal 12 / 1 (Ocak 2012): 22-31 .
AMA Çakır B. İnsülin Analoglarının Diyabetes Mellitus Tedavisindeki Rolü ve Faydaları. Ankara Med J. 2012; 12(1): 22-31.
Vancouver Çakır B. İnsülin Analoglarının Diyabetes Mellitus Tedavisindeki Rolü ve Faydaları. Ankara Medical Journal. 2012; 12(1): 22-31.
IEEE B. Çakır , "İnsülin Analoglarının Diyabetes Mellitus Tedavisindeki Rolü ve Faydaları", Ankara Medical Journal, c. 12, sayı. 1, ss. 22-31, Oca. 2012