Beslenmede Metilasyon Döngüsü Kavramı ve Hastalık İlişkileri

Öz

Etkisi en çok araştırılmış epigenetik mekanizma olan metilasyon; genomun normal yapıda düzenlenmesini sağlayan kimyasal bir tepkimedir. DNA metilasyon kalıpları, gelişim ve yaşlanma ile birlikte değişir, hücre tipleri arasında farklılık gösterir. Metilasyondaki bozukluklar birçok hastalığın patogenezinde rol oynar. Epigenetik süreçte beslenmenin rolü büyüktür. DNA metilasyon kalıpları diyet faktörleri tarafından modüle edilebilir. Kötü beslenme alışkanlıkları metabolik ya da kimyasal modifikasyonlara neden olarak gen ekspresyonu değiştirebilir. Özellikle kanser, obezite, kardiyovasküler hastalıklar, diyabet gibi hastalıklardaki metilasyon döngüsünün rolünün bilinmesi bu hastalıkların patogenezinin aydınlatılması için büyük önem arz etmektedir. Bu derlemede metilasyon döngüsü, beslenmede metilasyon döngüsü kavramı ve hastalık ilişkileri anlatılmıştır.

Anahtar Kelimeler

• DNA Metilasyonu
• Epigenetik
• Beslenme
• DNA Methylation
• Epigenetics
• Nutrition.

The Concept of Methylation Cycle in Nutrition and Its Relationships

Öz

Methylation, which is the most studied epigenetic mechanism, is a chemical reaction that allows the genome to be arranged in its normal structure. DNA methylation patterns change with development and aging, differing between cell types. Disorders in methylation play a role in the pathogenesis of many diseases. Nutrition plays an important role in the epigenetic process. DNA methylation patterns can be modulated by dietary factors. Poor dietary habits can alter gene expression by causing metabolic or chemical modifications. Understanding the role of the methylation cycle in diseases such as cancer, obesity, cardiovascular diseases, diabetes is of considerable importance for elucidating the pathogenesis of diseases. In this review, the methylation cycle, the concept of the methylation cycle in nutrition and disease relationships are explained.

Anahtar Kelimeler

• DNA Methylation
• Epigenetics
• Nutrition

Kaynakça

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