Kanser Hastalarında Polifarmasi ve İlaç Etkileşimleri

Bu makalenin ilk hali 31 Ocak 2022 tarihinde yayımlandı. https://dergipark.org.tr/tr/pub/amusbfd/article/922779

Düzeltme Notu

Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi 6. Cilt 1. Sayısında yer alan Karakoç'un “Kanser Hastalarında Polifarmasi ve İlaç Etkileşimleri” (Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi, 2023;6(1):31-42) başlıklı makalesinde: giriş bölümünde yer alan " Çalışmamızda, son yedi yılda hastanemizde takip edilen SSS enfeksiyonları irdelenerek hasta yönetiminde yardımcı olmak amaçlanmıştır." cümlesi sehven yazılmış olup bu cümle silinerek düzeltilmiştir.

Öz

Amaç: Kanser hastaları, sitotoksik ajanlar başta olmak üzere pek çok ilacın uygulanması nedeniyle ilaç-ilaç etkileşimleri açısından önemli bir risk altındadır. Çalışmada kanser hastalarının polifarmasi ve potansiyel ilaç-ilaç etkileşimleri bakımından mercek altına alınması amaçlanmıştır.
Yöntem: Araştırma, 18 yaşından büyük, kemoterapi tedavisi görmekte olan 202 adet gönüllü kanser hastası ile gerçekleştirildi. Kanser türü, ilaç kullanımı ve demografik bilgiler hasta bilgi formları ile hasta tedavi dosyalarından temin edildi. İlaçlar arasındaki etkileşimler Rx Media Pharma® programı ve www.drugs.com ilaç etkileşimi sorgulama web sitesi kullanılarak belirlendi. p<0.05 istatistiksel olarak anlamlı kabul edildi.
Bulgular: Çalışmada, bir kanser hastasının ortalama olarak sekiz ilaç kullanmakta olduğu ve %82.7’sin de polifarmasi varlığı saptandı. Çalışmada, hasta başına yaklaşık 3.5 ilaç-ilaç etkileşimi tespit edildi. Bu etkileşimlerin %85’inin klinik olarak dikkate alınması gereken orta ve yüksek düzey etkileşimler olduğu belirlendi. Kanser türleri içerisinde toplamda en az ilaç kullanan grubun meme tümörlü hastalar olduğu saptandı ve bunun bir sonucu olarak diğer tümör tiplerine sahip hastalara göre daha az ilaç etkileşimi olduğu belirlendi (p=0.01). Katılımcıların %48’inin kanser haricinde en az bir komorbiditeye sahip olduğu tespit edildi.
Sonuç: Araştırmada kanser hastalarında komorbidite ve polifarmasinin oldukça yaygın olduğu tespit edildi. Polifarmasinin bir sonucu olarak kanser hastaları arasında önemli miktarda ilaç–ilaç etkileşimleri olduğu saptandı. İlaç etkileşimlerinin engellenmesi için tüm paydaşlara önemli sorumluluklar düşmekte ve bu konuda çok merkezli çalışmalara ihtiyaç bulunmaktadır.  

Anahtar Kelimeler

• Kanser
• İlaç etkileşimleri
• Polifarmasi
• Komorbidite

Polypharmacy and Drug Interactions in Cancer Patients

Bu makalenin ilk hali 31 Ocak 2022 tarihinde yayımlandı. https://dergipark.org.tr/tr/pub/amusbfd/article/922779

Düzeltme Notu

In Karakoç's article titled "Polypharmacy and Drug Interactions in Cancer Patients " (Adnan Menderes University Faculty of Health Sciences Journal, 2023;6(1):31-42) in the 6th Volume 1st Issue of Adnan Menderes University Faculty of Health Sciences Journal: "Çalışmamızda, son yedi yılda hastanemizde takip edilen SSS enfeksiyonları irdelenerek hasta yönetiminde yardımcı olmak amaçlanmıştır." this sentence, which was in the introduction section, was written by mistake and has been corrected by deleting it.

Öz

Objective: Cancer patients are under an important risk in terms of drug-drug interactions (DDIs) because administration of many drugs, especially cytotoxic agents. The aim of this study is examine the cancer patients in terms of polypharmacy and potential DDIs.
Methods: The study was conducted with 202 volunteer cancer patients over the age of 18 who were receiving chemotherapy treatment. Cancer type, drug usage and demographic data were obtained by patient information forms and patients' treatment files. Interactions between drugs were determined using the Rx Media Pharma® software and the www.drugs.com DDIs control web page. p<0.05 was considered statistically significant.
Results: It was determined that a cancer patient was receiving eight drugs on average and 82.7% of them had polypharmacy. In the study, approximately 3.5 DDIs were detected per patient. It was found 85% of these interactions were medium and high level interactions that should be clinically take into account. It was determined that the minimum drug using group among the cancer types were breast cancer patients and there were less DDIs compared to patients with other tumor types (p=0.01). It was detected that 48% of the participants had at least one comorbidity other than cancer.
Conclusion: In the study, it was determined that comorbidities and polypharmacy are quite common in cancer patients. As a result of polypharmacy, a significant amount of DDIs have been found among cancer patients. In order to preventing the DDIs, all stakeholders have important responsibilities and multi-center studies are needed on this issue.

Anahtar Kelimeler

• Cancer
• Drug interactions
• Polypharmacy
• Comorbidity

Kaynakça

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