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Polycystic Ovary Syndrome and Obesity: The Role of FTO and MC4R Gene Polymorphisms

Yıl 2020, , 275 - 295, 30.09.2020
https://doi.org/10.46237/amusbfd.722771

Öz

Polycystic Ovary Syndrome (PCOS) is a multifactorial endocrine disorder with a complex etiology. It is also associated with metabolic disorders that increase the risk of developing obesity and type 2 diabetes in women. Obesity / adiposity and insulin resistance is a common problem in women with PCOS. Genome projects, which examine the human genome in detail, have been shown to have a large number of genes and genetic variations associated with obesity and some diseases. Among these genes, fat mass and obesity-associated gene (FTO) and melanocortin-4 receptor gene (MC4R) variants are associated with obesity, excess body weight, and type 2 diabetes. Therefore, it is suggested that genes, FTO and MC4R, may be associated with PCOS through the effects of obesity / adiposity development. In this review article, the relationship of some obesity-related gene polymorphisms (FTO and MC4R) with PCOS has been investigated.

Kaynakça

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Polikistik Over Sendromu ve Obezite: FTO ve MC4R Gen Polimorfizmlerinin Rolü

Yıl 2020, , 275 - 295, 30.09.2020
https://doi.org/10.46237/amusbfd.722771

Öz

Polikistik Over Sendromu (PKOS) etiyolojisi karmaşık olan multifaktöriyel bir endokrin bozukluktur. Ayrıca kadınlarda obezite ve tip 2 diyabet gelişim riskini arttıran metabolik bozukluklarla da ilişkilidir. Obezite/adipozite ve insülin direnci PKOS’lu kadınlarda oldukça sık karşılaşılan bir problemdir. İnsan genomunun ayrıntılı olarak incelendiği genom projelerinde obezite ve bazı hastalıklarla ilişkili çok sayıda gen ve genetik varyasyonların bulunduğu gösterilmiştir. Bu genler içerisinde yağ kütlesi ve obezite ile ilişkili gen (FTO) ve melanokortin-4 reseptör geni (MC4R) varyantları obezite, aşırı vücut ağırlığı ve tip 2 diyabet ile ilişkilidir. Bu nedenle FTO ve MC4R genlerinin obezite/adipozite gelişimine etkileri yoluyla PKOS ile ilişkili olabileceği öne sürülmektedir. Bu derleme makalede obeziteyle ilişkili bazı gen polimorfizmlerinin (FTO ve MC4R) PKOS ile ilişkisi incelenmiştir.

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  • 97. Freathy, R. M., Timpson, N. J., Lawlor, D. A., Pouta, A., Ben-Shlomo, Y., Ruokonen, A., et al. (2008). Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes, 57(5), 1419-1426.
  • 98. Kowalska, I., Adamska, A., T. Malecki, M., Karczewska‐Kupczewska, M., Nikolajuk, A., Szopa, M., et al. (2012). Impact of the FTO gene variation on fat oxidation and its potential influence on body weight in women with polycystic ovary syndrome. Clinical Endocrinology, 77(1), 120-125.
  • 99. Kim, J. J., Choi, Y. M., Hong, M. A., Kim, J. M., Hwang, S. S., Lee, G. H., et al. (2014). Gene dose effect between a fat mass and obesity-associated polymorphism and body mass index was observed in Korean women with polycystic ovary syndrome but not in control women. Fertility and Sterility, 102(4), 1143-1148.
  • 100. Song, D. K., Lee, H., Oh, J.-Y., Hong, Y. S., & Sung, Y.-A. (2014). FTO gene variants are associated with PCOS susceptibility and hyperandrogenemia in young Korean women. Diabetes & Metabolism Journal, 38(4), 302-310.
  • 101. Ramos, R. B., Casanova, G. K., Maturana, M. A., & Spritzer, P. M. (2011). Variations in the fat mass and obesity–associated (FTO) gene are related to glucose levels and higher lipid accumulation product in postmenopausal women from southern Brazil. Fertility and Sterility, 96(4), 974-979.
  • 102. Shahid, A., Rana, S., Saeed, S., Imran, M., Afzal, N., & Mahmood, S. (2013). Common variant of FTO gene, rs9939609, and obesity in Pakistani females. BioMed Research International. https://doi.org/10.1155/2013/324093.
  • 103. Li, T., Wu, K., You, L., Xing, X., Wang, P., Cui, L., et al. (2013). Common variant rs9939609 in gene FTO confers risk to polycystic ovary syndrome. PLoS One, 8(7), e66250.
  • 104. Yuan, H., Zhu, G., Wang, F., Wang, X., Guo, H., & Shen, M. (2015). Interaction between common variants of FTO and MC4R is associated with risk of PCOS. Reproductive Biology and Endocrinology, 13(1), 55.
  • 105. Batarfi, A. A., Filimban, N., Bajouh, O. S., Dallol, A., Chaudhary, A. G., & Bakhashab, S. (2019). MC4R variants rs12970134 and rs17782313 are associated with obese polycystic ovary syndrome patients in the Western region of Saudi Arabia. BMC Medical Genetics, 20(1), 144.
  • 106. Thorleifsson, G., Walters, G. B., Gudbjartsson, D. F., Steinthorsdottir, V., Sulem, P., Helgadottir, A., et al. (2009). Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nature Genetics, 41(1), 18-24.
  • 107. Ewens, K. G., Jones, M. R., Ankener, W., Stewart, D. R., Urbanek, M., Dunaif, A., et al. (2011). FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome. PLoS One, 6(1), e16390.
  • 108. Louwers, Y. V., Rayner, N. W., Herrera, B. M., Stolk, L., Groves, C. J., Barber, T. M., et al. (2014). BMI-associated alleles do not constitute risk alleles for polycystic ovary syndrome independently of BMI: a case-control study. PLoS One, 9(1), e87335.
  • 109. Tan, S., Scherag, A., Janssen, O. E., Hahn, S., Lahner, H., Dietz, T., et al. (2010). Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS). BMC Medical Genetics, 11(1), 12.
  • 110. Mahmoudi, H., Redler, S., Birch, P., Drichel, D., Dobson, K., Tazi-Ahnini, R., et al. (2013). Selected variants of the melanocortin 4 receptor gene (MC4R) do not confer susceptibility to female pattern hair loss. Archives of Dermatological Research, 305(3), 249-253.
Toplam 111 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Derleme Makaleler
Yazarlar

Ayçıl Özturan Şirin 0000-0003-2145-3626

Yasemin Akdevelioğlu 0000-0002-2213-4419

Yayımlanma Tarihi 30 Eylül 2020
Yayımlandığı Sayı Yıl 2020

Kaynak Göster

APA Özturan Şirin, A., & Akdevelioğlu, Y. (2020). Polikistik Over Sendromu ve Obezite: FTO ve MC4R Gen Polimorfizmlerinin Rolü. Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi, 4(3), 275-295. https://doi.org/10.46237/amusbfd.722771