Vitamin D and Its Anticarcinogenic Effects

Öz

Vitamin D is identified as a hormon-like group of sterols, dissolved in oil and organic solvents, but do not dissolve in water act as hormones, because it reaches every organ and tissue through their receptors and perform important tasks. It plays a fundamental role in maintaining calcium and phosphorus metabolism. Many studies have revealed that the active form of vitamin D (1,25-(OH)2D3) has also cell proliferation, apoptotic and antioxidant effects. The purpose of this review is to highlight the major role of vitamin D and its metabolites, as well as cancer and their relation to autoimmune diseases, immune system.

Anahtar Kelimeler

• Vitamin D
• Antioxidants
• Cancer

Vitamin D ve Antikanserojenik Etkileri

Öz

Vitamin D, yağda ve organik çözücülerde çözünen, fakat suda çözünmeyen, sahip olduğu reseptörleri aracılığıyla her organ ve dokuya ulaşıp önemli görevler yapması sebebiyle hormon benzeri görev yapan bir grup sterol olarak ifade edilir. Kalsiyum ve fosfor metabolizmasının devamlılığının sağlanmasında majör rol oynar. Yapılan pek çok çalışmada, D vitamininin aktif formu olan 1,25-OH2D3’ün aynı zamanda hücre proliferasyonu, apoptotik ve antioksidan etkilerinin de olduğu ortaya çıkarılmıştır. Bu derlemenin amacı, vitamin D ve metabolitlerinin herkes tarafından bilinen majör rolünün yanı sıra kanser ve buna bağlı olarak otoimmun hastalıklar, bağışıklık sistemi ile ilgili ilişkilerini vurgulamaktır.

Anahtar Kelimeler

• Vitamin D
• Antioksidanlar
• Kanser

Kaynakça

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