Exercise-induced Weight Loss and Glutathione S-Transferase

Öz

Objective: In this study, it was aimed to investigate the effect of weight loss observed in exercised rats on Glutathione S-Transferase enzyme activity.
Methods: The rats were exercised for 10 days. Melatonin and niacin were given to one group in order to create a difference in weight loss between groups. The rats were weighed throughout the study. Intracardiac blood samples were taken, one day after the last exercise. Glutathione S-Transferase enzyme activity was measured.
Results: Weight loss was observed in the groups. It was observed that the weight loss in the melatonin and niacin group was significant, considering body weight (p<0.001). Glutathione S-Transferase enzyme activity of this group with higher weight loss was observed to be lower than the other group (p<0.001). There was an inverse correlation between the weight loss observed in the groups and the analyzed Glutathione S-Transferase enzyme activity levels (p<0.001).
Conclusion: Approximately 4% weight loss occurred in one group. There was an inverse correlation between exercise-induced weight loss and Glutathione S-Transferase enzyme activity.

Anahtar Kelimeler

• Exercise
• Weight Loss
• Glutathione S-Transferase

Proje Numarası

TPF 19011

Egzersize Bağlı Kilo Kaybı ve Glutatyon S-Transferaz

Öz

Amaç: Bu çalışmada, egzersiz yaptırılan ratlarda gözlenen kilo kaybının, Glutatyon S-Transferaz enzim aktivitesi üzerine etkisinin araştırılması amaçlanmıştır.
Yöntem: Ratlara 10 günlük egzersiz yaptırıldı. Gruplar arası kilo kaybı farkı oluşması amacıyla bir gruba melatonin ve niasin verildi. Çalışma boyunca ratlar tartıldı. Son egzersizden bir gün sonra intrakardiyak kan örnekleri alındı. Glutatyon S-Transferaz enzim aktivitesi ölçüldü.
Bulgular: Gruplarda kilo kaybı gözlendi. Vücut ağırlığı dikkate alındığında, melatonin ve niasin verilen grupta oluşan kilo kaybının anlamlı olduğu gözlendi (p<0.001). Kilo kaybı daha yüksek olan bu grubun Glutatyon S-Transferaz enzim aktivitesi, diğer gruptan daha düşük olduğu gözlendi (p<0.001). Gruplarda gözlenen kilo kaybı ile analizi yapılan Glutatyon S-Transferaz enzim aktivite düzeyleri arasında zıt yönlü korelasyon olduğu gözlendi (p<0.001).
Sonuç: Bir grupta yaklaşık %4 düzeyinde kilo kaybı oluştu. Egzersize bağlı kilo kaybı ile Glutatyon S-Transferaz enzim aktivitesi arasında zıt yönde bir korelasyon olduğu saptandı.  

Anahtar Kelimeler

• Egzersiz
• Kilo Kaybı
• Glutatyon S-Transferaz

Destekleyen Kurum

Aydın Adnan Menderes Üniversitesi Bilimsel Araştırma Projeleri Birimi

Proje Numarası

TPF 19011

Teşekkür

Bu çalışma, Aydın Adnan Menderes Üniversitesi Bilimsel Araştırma Projeleri Birimi tarafından TPF 19011 proje numarası ile desteklenmiştir. Çalışma sürecinde yardımlarından dolayı ilgili birime şükranlarımızı sunarız.

Kaynakça

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