Covid-19 Yoğun Bakım Hastalarını Ayırt Etmek İçin Kullanılabilecek Laboratuvar Testleri

Yıl 2023, Cilt: 7 Sayı: 1, 208 - 216, 31.01.2023

Leyla Demir , Serap Çuhadar , Tuğba Öncel Van , Saliha Aksun

https://doi.org/10.46237/amusbfd.1230484

Öz

Amaç: COVID-19 pandemisinde yoğun bakım ihtiyacı artmıştır ve bu süreçte laboratuvar parametreleri önem kazanmıştır. RT-PCR(+) 60 servis ve 26 yoğun bakım COVID-19 hastasının başvuru semptomlarını, eşlik eden hastalıklarını, yaş ortalamasını ve laboratuvar verilerini retrospektif olarak değerlendirip, hastaların klinik ve laboratuvar özelliklerini ortaya koymayı prognoz hakkında bize yardımcı olacak parametreleri belirlemeyi amaçladık.
Yöntem: RT-PCR (+) COVID-19 hastalarının verileri hastane ve laboratuvar bilgi sistemlerinden geriye dönük olarak toplandı. Hastanemizde tedavi gören toplam 86 COVID-19 hastası, yatan hastalar ve yoğun bakım hastaları olarak gruplandırıldı. Hastaneye başvuru semptomları, komorbid hastalıkları ve laboratuvar verileri istatistiksel olarak değerlendirildi.
Bulgular: Çalışma popülasyonunun ortalama yaşları yoğun bakım ve servis hastalarında sırasıyla 64 ve 58 idi. Yoğun bakım hastalarının %73'ünde, servis hastalarının %51,6'sında komorbid hastalık saptandı. Her iki grupta da hipertansiyon (43%) ve diabetes mellitus (22%) en sık eşlik eden hastalıklardı. Yoğun bakım hastalarında nötrofil [(6.11(1.18-19.7) ile 3.83(1.51-12.07) 109 /L, p=0.007], nötrofil/lenfosit oranı [5.74 (1.34-28.86) ile 2.11 (0.64-9.14), p<0.001], D-dimer [ 482 (52-2522) ile 249 (59-3561) µg/L, p=0.001], CRP [91.8 (0.49-331.7) ile 14 (0-161) mg/L, p< 0.001] ve prokalsitonin [0.19 (0-6.94) ile 0.04 (0-0.86) µg/L, p< 0.001] değerleri anlamlı olarak daha yüksek, lenfosit [(1.12±0.54 ) ile ( 1.81±0.90) 109 /L, p<0.001] değerleri daha düşük olarak bulundu.
Sonuç: COVID-19 virüsü insanları etkilemeye devam etmekte ve bazı hastalarda yoğun bakım ihtiyacı görülmektedir. Yoğun bakım hastalarında lenfopeni ve nötrofil, N/L oranı, D-dimer, CRP, prokalsitonin düzeylerindeki artış dikkat çekicidir.  

Anahtar Kelimeler

COVID-19, Lenfopeni, D-dimer, CRP, Prokalsitonin, Lymphopenia, Procalcitonin

Destekleyen Kurum

Çalışmamız herhangi bir destek almamıştır.

Proje Numarası

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Laboratory Tests to Distinguish COVID-19 Intensive Care Patients

Öz

Objective: The need for intensive care units has increased in the COVID-19 pandemic, and in this process, laboratory parameters are important. We aimed to evaluate the admission symptoms retrospectively, comorbid diseases, mean age, and laboratory data of RT-PCR(+) 60 service and 26 intensive care COVID-19 patients, to reveal the clinical and laboratory characteristics of the patients and to define the parameters that will help us about the prognosis..
Methods: We divided 86 COVID-19 RT-PCR (+) patients treated in our hospital into two groups as inpatients and intensive care patients. We compared symptom, comorbid disease and laboratory data in these patient groups and compared laboratory data statistically.
Results: In our study, while the mean age of intensive care patients was 64, it was 58 in service patients. Comorbid diseases were found in 73% of intensive care patients and 51.6% in service patients. Hypertension (43%) and diabetes mellitus (22%) are the most common comorbid diseases in both groups. In addition, while neutrophil [(6.11(1.18-19.7) vs. 3.83(1.51-12.07) 109 /L, p=0.007], N/L ratio [5.74 (1.34-28.86) vs. 2.11 (0.64-9.14), p<0.001], D-dimer [ 482 (52-2522) vs. 249 (59-3561) µg/L, p=0.001], CRP [91.8 (0.49-331.7) vs. 14 (0-161) mg/L, p< 0.001], and procalcitonin [0.19 (0-6.94) vs. 0.04 (0-0.86) µg/L, p< 0.001] values were found to be significantly higher in intensive care patients, lymphocyte values [(1.12±0.54 ) vs. ( 1.81±0.90) 109 /L, p<0.001] were found to be significantly lower.
Conclusion: COVID-19 is still affecting our world, and patients need intensive care. Lymphopenia, increase in neutrophil level, N/L ratio, D-dimer, CRP and procalcitonin levels are remarkable in intensive care patients.

Anahtar Kelimeler

COVID-19, Lymphopenia, D-dimer, CRP, Procalcitonin

Proje Numarası

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Kaynakça

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