Propolisin İnsan Sağlığına Etkileri

Banu Yücel; Erkan Topal; Eren Akçiçek; Mustafa Kösoğlu

TR

Propolisin İnsan Sağlığına Etkileri

Öz

Son yıllarda insan sağlığına yönelik kullanılan ilaçların etkinliğinin azalması, yan etkilerinin ortaya çıkması ve artması, ekonomik kayıpların meydana gelmesi gibi birçok olumsuzluğun sonucu olarak doğal ürünlere giderek artan bir yönelim oluşmaya başlamıştır. Bu yönelimin en çok yaşandığı grupların başında arı ürünleri gelmektedir. Arı ürünleri antibakteriyel, antioksidan, antifungal, antiinflamatuar, antitümör, antiseptik özellikleri nedeniyle tıp, ilaç ve gıda sektörü başta olmak üzere kamuoyunda oldukça ilgi görmektedir. Dünya’nın pek çok ülkesinde arı ürünleri ile tedavi (apiterapi) uygulamaları yapılmakta ve önemli tıbbi destek olarak saygın bilim otoritelerince kabul görmektedir. Ülkemizde ise son zamanlarda gündeme gelen apiterapi ve arı ürünleri tüketiciler tarafından takip edilmekte ve yeni bir pazar oluşmaktadır. Arı ürünlerinde en yoğun çalışmalar “doğal antibiyotik” olarak kabul edilen propolisin üzerinde yürütülmektedir. Bu derlemede, propolisin insan sağlığı üzerine etkilerine yönelik yapılmış çalışmaların bir kısmı belli başlıklar altında verilerek, sağlık üzerine etkisi vurgulanmaya çalışılmış, konu ile ilgili farkındalığın artırılması ve konuya yönelik potansiyel çalışmalara ışık tutması hedeflenmiştir.

Anahtar Kelimeler

Propolis,bal arısı,apiterapi,sağlık,arı ürünü

Kaynakça

Ahn, M. R., S. W. Kim, S. Kumazawa, and T. Ohta. 2013. Artepillin C suppresses aAngiogenesis by inhibiting tube-formation and inducing apoptosis of endothelial cells. Journal of Food and Nutrition Research 1 (5): 92-96.
Aksoy, S., F. Armutçu, and M. R. Yiğitoğlu. 2011. Using of caffeic acid phenetil ester (CAPE) the active substance of propolis in some neurologic disease and emergency. Spatula DD. 1 (1): 37-42.
Aso, K., S. Kanno, T. Tadano, S. Satoh, and M. Ishikawa. 2004. Inhibitory effect of propolis on the growth of human leukemia U937. Biol Pharm Bull. 27: 727-730.
Balata, G., H. M. El Nahas, and S. Radwan. 2014. Propolis organogel as a novel topical delivery system for treating wounds. Drug Delivery 21 (1): 55-61.
Bankova, V. 2005. Recent trends and important developments in propolis research. eCAM. 2 (1): 29-32.
Barak, V., S. Birkenfeld, and T. Halperin. 2002. The effect of herbal remedies on the production of human inflammatory and anti-inflammatory cytokines. Isr Med Assoc. J. 4 (11 Suppl): 919-922.
Barlak, Y., O. Değer, M. Çolak, S. C. Karataylı, A. M. Bozdayı, and F. Yücesan. 2011. Effect of Turkish propolis extracts on proteome ofprostate cancer cell line. Proteome Science 9: 74.
Basista, K. M., and B. Filipek. 2012. Allergy to propolis in Polish beekeepers. Postep Derm Alergol. 6: 440-445.
Biray, Ç., C. Gündüz, B. Yılmaz, F. Şahin, and N. Toğçuoğlu. 2006. The evaluation of cytotoxic and apoptotic effect of propolis and its extracts caffeic acid phenethyl ester and cinnamic acid in human acute t-cell lymphoblastic leukemia cell line (CCRF-CEM] Ege Tıp Dergisi 45 (2) : 83-92.
Black, R. J. 2005. Vulval eczema associated with propolis sensitization from topical therapies treated successfully with pimecrolimus cream. Clin Exp Dermatol. 30 (1): 91-92.

Borrelli, F., P. Maffia, and L. Pinto. 2002. Phytochemical compounds involved in the anti inflammatory effect of propolis extract. Fitoterapia 73 (1): 53-63.
Botushanov, P. I., G. I. Grigorov, and G. A. A. Aleksandrov. 2001. Clinical study of a silicate toothpaste with extract from propolis. Folia Med (Plovdiv). 43 (1-2): 28-30.
Boyanova, L., S. Derejian, R. Koumanova, N. Katsarov, G. Gergova, I. Mitov, and Z. Krastev. 2003. Inhibition of helicobacter pylori growth in vitro by Bulgarian propolis: preliminary report. Journal of Medical Microbiology 52 (5): 417-419.
Camargo, M. S., A. M. F. A. Resende, P. K. Boldrin, and C. R. Cardoso. 2013. Evaluation of estrogenic, antiestrogenic and genotoxic activity of nemorosone, the major compound found in brown Cuban propolis. BMC Complement Altern Med. 31 (13): 201.
Ciaceri, G., and G. Attaguile.1972. Influenza della luteolina, ded'apigenina e dell'acace-sull'ulcera gastrica sperimentale. Minerva Med. 63 (29): 1665-1668.
Cicala, C., S. Morello, and C. Iorio. 2003. Vascular effects of caffeic acid phenethyl ester (CAPE) on isolated rat thoracic aorta. Life Sci. 73 (1): 73-80.
Cohen, H. A., I. Varsano, E. Kahan, M. Sarrell, and Y. Uziel. 2004. Effectiveness of an herbal preparation containing echinacea, propolis, and vitamin C in Preventing Respiratory Tract Infections in Children. Arch Pediatr Adolesc Med. 158: 217-221.
Crişan, B., C. N. Zaharia, F. Popovici, V. Jucu, O. Belu, C. Dascălu, A. Mutiu, and A. Petrescu. 1995. Natural propolis extract NIVCRISOL in the treatment of acute and chronic rhinopharyngitis in children. Romanian Journal of Virology 46 (3-4): 115-133.
Daidone, M. G., R. Silvestrini, B. Velentinis, P. G. Mezzanotte, P. Squicciarini, S. Orefice, and B.Salvadori. 1990. Proliferative activity of primary breast cancer and of synchronous lymph node metastases evaluated by 3H- Tyhmidine labelling index. Cell Tissue Kinet. 23: 401-8.
Erdem, G. B., and S. Ölmez. 2004. Inhibitory Effect of Bursa Propolis on Dental Caries Formation in Rats Inoculated with Streptococcus sobrinus. Turk J. Zool. 28: 29-36.
Eroğlu, H. E., A. Tatlışen, and Y. Özkul. 2004. Effects of propolis and mitomycın-C on micronucleusin tissue cultures of bladder cancer. Erciyes Üniversitesi Sağlık Bilimleri Dergisi 13 (2): 15-20.
Farooqui, T., and A. A. Farooqui. 2012. Beneficial effects of propolis on human health and neurological diseases. Frontiers in Bioscience E4: 779-793.
Focht, J., S. H. Hansen, J. V. Nielsen, A. Van Den Berg-Segers, and R. Riezler. 1993. Bactericidal effect of propolis in vitro against agents causing upper respiratory tract infections. Arzneimittel-Forschung 43 (8): 921-923.
Fuliang, H. U., H. R. Hepburn, H. Xuan, M. Chen, S. Daya, and S. E. Radloff. 2005. Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus. Pharmacol Res. 51 (2): 147-52.
Gafar, M., M. Puchita, B. Popa, and G. Pambuccian. 1989. Anatomo-clinical studies on contraindications of biological treatment of the dental pulp in some cronic general diseases. Rev Chir Oncol Radiol ORL Oftalmol Stomatol Ser Stomatol. 36 (2): 99-108.
Ghisalberti, E. L. 1979. Propolis: A Review. Bee World 60 (2): 59-84.
Güney, M., B. Oral, N. Karahan, and T. Mungan. 2007. Protective effect of caffeic acid phenethyl ester (CAPE) on fluoride-induced oxidative stress and apoptosis in rat endometrium. Environ Toxicol Pharmacol. Sep. 24 (2): 86-91.
Hartwich, A., J. Legutko, and J. Wszolek. 2000. Propolis: its properties and administration to patients treated for some surgical diseases. Przegl Lek. 57: 191-194.
Hubbezoğlu, İ., Ü. Özan, and Z. Sümer. 2011. Effects on Escherichia coli of solutions containing propolis and potassium titanium phosphate laser in root canal irrigation. Atatürk Üniv. Diş Hek. Fak. Derg. 21 (1): 15-21.
Imhof, M., M. Lipovac, Ch. Kurz, J. Barta, H. C. Verhoeven, and J. C.Huber. 2005. Propolis solution for the treatment of chronic vaginitis. Int. J. Gynaecol Obstet. May 89 (2): 127-32.
Jaganathan, S. K., and M. Mandal. 2010. Involvement of non-protein thiols, mitochondrial dysfunction, reactive oxygen species and p 53 in honey-induced apoptosis, Invest New Drugs 28: 624-633.
Kakino, M., H. Izuta, K. Tsuruma, Y. Araki, M. Shimazawa, K. Ichihara, and H. Hara. 2012. Laxative effects and mechanism of action of Brazilian green propolis. BMC Complementary and Alternative Medicine 12: 192.
Kamburoğlu, K., and T. Özen. 2011. Analgesic effect of Anatolian propolis in mice. Ağrı. 23 (2): 47-50.
Koru, Ö., F. Toksoy, C. H. Açikel, Y. M. Tunca, and M. Baysallar. 2007. In vitro antimicrobial activity of propolis samples from different geographical origins against certain oral pathogens. Anaerobe 13 (3-4): 140–145.
Kurt, F. Ö., S. H. Vatansever, K. Sorkun, S. I. D. Gürhan, and E. Türkoz. 2010. Inhibitory effects of propolis on human osteogenic sarcoma cell proliferation mediated by caspase patway. Kafkas Univ. Vet. Fak. Dergisi 16 (3): 397-404.
Lavigne, J. P., X. Vitrac,L. Bernard, F. Bruyère, and A. Sotto. 2011. Propolis can potentialise the anti-adhesion activity of proanthocyanidins on uropathogenic Escherichia coli in the prevention of recurrent urinary tract infections. BMC Research Notes 4 (1): 522.
Lisičić, D., V. Benković, D. Đikić, A. S. Blažević, J. Mihaljević, N. Oršolić, and A. H. Knežević. 2014. Addition of propolis to irinotecan therapy prolongs survival in ehrlich ascites tumor-bearing mice. Cancer Biotherapy & Radiopharmaceuticals 29 (2): 62-69.
Luo, J., J. W. Soh, W. Q. Xing, Y. Mao, T. Matsuno, and I. B. Weinstein. 2001. PM-3, a benzo-gamma-pyran derivative isolated from propolis, inhibits growth of MCF-7 human breast cancer cells, Anticancer Res. 21: 1665-1671.
Mahal, N. K., N. Singh, P. M. Thomas, and N. Kakkar. 2013. Effect of three different storage media on survival of periodontal ligament cells using collagenase-dispase assay. Int. Endod J. Apr. 46 (4): 365-70.
Morales, W. F., and J. L. Garbarino. 1997. Clinical evaluation of a new hypoallergic formula of propolis in dressings. Bee Products pp. 101-105.
Moreno, M. I. N., M. I. Isla, A. R. Sampietro, and M. A. Vattuone. 2000. Comparison of the freeradical-scavenging activity of propolis from several regions of Argentina. J. Ethnopharmacol 71: 109 -114.
Muscat, M. 2013. Use of Propolis chemical and Asian tiger mosquito bites - case report and review. Malta Medical Journal 25 (1): 58-61.
Nagai, T., R. İnoue, H. İnoue, and N. Suzuki, N. 2003. Preparation and antioxidant properties of water extract of propolis. Food Chemistry 80 (1): 29–33.
Omene, M., M. Kalac, J. Wu, E. Marchi, K. Frenkel, and O. A. Connor. 2013. Propolis and its active component, caffeic acid phenethyl ester (CAPE), modulate breast cancer therapeutic targets via an epigenetically mediated mechanism of action. J. Cancer Sci Ther. 5 (10): 334-342.
Oršolić, N., N. Car, D. Lisicic, V. Benkovic, A. H. Knezevic, D. Dikic, and J. Pertik. 2013. Synergism between propolis and hyperthermal intraperitoneal chemotherapy with cisplatin on ehrlich ascites tumor in mice. J. Pharm. Sci. 102 (12): 4395-405.
Özan, F., Z. A. Polat, K. Er, Ü. Ozan, and O. Değer, O. 2007. Effect of propolis on survival of periodontal ligament cells: New storage media for avulsed teeth. Journal of Endodontics 33 (5): 570-573.
Özcan, M., A. Ceylan, A. Ünver, and R. Yetişir. 2003. Antifungal effect of pollen and propolis extracts collected from different regions of Turkey. Uludağ Bee Journal August: 27-34.
Öztürk, A. İ. 2006. Propolis. Beekeper’s World 2 (1): 31-33.
Paintz, M., and J. Metzner . 1979. Zur lokalanasthetischen wirkung vin propolis und einigen inhaltsstofen. Pharmazie 34: 839-841.
Park, Y. K., M. H. Koo, and J. A. Abreu. 1998. Antimicrobial activity of propolis on oral microorganisms. Curr Microbiol. 36 (1): 24-28.
Parolia, A., S. M. Thomas, M. Kundabala, and M. Mohan. 2010. Propolis and its potential uses in oral health. International Journal of Medicine and Medical Sciences 2 (7): 210-215.
Pichichero, E., R. Cicconi, M. Mattei, M. G. Muzi, and A. Canini. 2010. Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression. Int. J. Oncol. 37: 973-981.
Pillai, S. I., P. Palsamy, S. Subramanian, and M. Kandaswamy. 2010. Wound healing properties of Indian propolis studied on excision wound-induced rats. Pharm Biol. Nov. 48 (11): 1198-206.
Salonen. A., S. Saarnio, and T. R. Julkenen. 2012. Phenolic compounds of propolisfrom the boreal coniferous zone. Journal of Apicultural Science 56 (1): 13-22.
Samarghandian, S., J. T. Afshari, and S. Davoodi. 2011. Honey induces apoptosis in renal cell carcinoma. Pharmacogn Mag. 7 (25): 46-52.
Sforcin, J. M. 2007. Propolis and the immune system: a review. Journal of Ethnopharmacology 113: 1-14.
Skiba, M., E. Szliszka, M. Kunicka, and W. Krol. 2011. Effect of ethanol extract of propolis (EEP) on interleukin 8 release by human gastric adenocarcinoma cells (AGS) infected with Helicobacter pylori. Central-European Journal of Immunology 36 (2): 65-69.
Sołtys, K. B. 2013. Allergy to Propolis in Beekeepers-A Literature Review. Occup Med Health Aff. 1: 1. Souza, E. A. D., H. T. Inoue, A. Fernandes Júnior, N. Veiga, and R. D. O. Orsi. 2014. Influence of seasonality and production method on the antibacterial activity of propolis. Acta Scientiarum. Animal Sciences 36 (1): 49-53.
Sönmez, Ş., L. Kırılmaz, M. Yücesoy, B. Yücel, and B., Yılmaz. 2005. The effect of propolis in oral pathogens and human gingival fibroblasts. Journal of Ethnopharmacology 102 (3): 371-376.
Speciale, A., R. Costanzo, S. Puglisi, R. Musumeci, M. R. Catania, F. Caccamo, and L. Iauk. 2006. Antibacterial activity of propolis and its active principles alone and in combination with macrolides, beta-lactams and fluoroquinolones against microorganisms responsible for respiratory infections. Journal of Chemotherapy (Florence, Italy). 18 (2): 164-171.
Szliszka, E., G. Zydowicz, B. Janoszka, C. Dobosz, G. K. Ziomek, and W. Krol. 2011. Ethanolic extract of Brazilian gren propolis sensitizes prostate cancer cells to TRAIL-induced apoptosis . International Journal of Oncology 38 (4): 941-953.
Uzel, A., K. Sorkun, O. Onçağ, D. Cogŭlu, O. Gençay, and B. Salih. 2005. Chemical compositions and antimicrobial activities of four different Anatolian propolis samples. Microbiol Res. 160 (2): 189-95.
Vaz Coelho, L. G., E. M. A. Ferreira Bastos, C. C. Resende, P. Silva, C. Mirra, F. Sanches, and O. R. Trindade. 2007. Brazilian green propolis on Helicobacter pylori infection. A pilot clinical study. Helicobacter 12 (5): 572-574.
Vynograd, N., I. Vynograd, and Z. Sosnowski. 2000. A comparative multi-centre study of the efficacy of propolis, acyclovir and placebo in the treatment of genital herpes (HSV). Phytomedicine 7 (1): 1-6.
Wei, X., L. Zhao, Z. Ma, D. M. Holtzman, C. Yan, and R. C. Dodel. 2004. Caffeic acid phenethyl ester prevents neonatal hypoxic-ischaemic brain injury. Brain. 127 (12): 2629-35.

Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

Derleme

Yazarlar

Banu Yücel
Türkiye

Erkan Topal
Türkiye

Eren Akçiçek
Türkiye

Mustafa Kösoğlu Bu kişi benim

Yayımlanma Tarihi

20 Aralık 2014

Gönderilme Tarihi

13 Temmuz 2017

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2014 Cilt: 24 Sayı: 2

IZ

https://izlik.org/JA67MU24ST

APA

Yücel, B., Topal, E., Akçiçek, E., & Kösoğlu, M. (2014). Propolisin İnsan Sağlığına Etkileri. ANADOLU Journal of Aegean Agricultural Research Institute, 24(2), 41-49. https://izlik.org/JA67MU24ST

AMA

1.Yücel B, Topal E, Akçiçek E, Kösoğlu M. Propolisin İnsan Sağlığına Etkileri. ANADOLU. 2014;24(2):41-49. https://izlik.org/JA67MU24ST

Chicago

Yücel, Banu, Erkan Topal, Eren Akçiçek, ve Mustafa Kösoğlu. 2014. “Propolisin İnsan Sağlığına Etkileri”. ANADOLU Journal of Aegean Agricultural Research Institute 24 (2): 41-49. https://izlik.org/JA67MU24ST.

EndNote

Yücel B, Topal E, Akçiçek E, Kösoğlu M (01 Aralık 2014) Propolisin İnsan Sağlığına Etkileri. ANADOLU Journal of Aegean Agricultural Research Institute 24 2 41–49.

IEEE

[1]B. Yücel, E. Topal, E. Akçiçek, ve M. Kösoğlu, “Propolisin İnsan Sağlığına Etkileri”, ANADOLU, c. 24, sy 2, ss. 41–49, Ara. 2014, [çevrimiçi]. Erişim adresi: https://izlik.org/JA67MU24ST

ISNAD

Yücel, Banu - Topal, Erkan - Akçiçek, Eren - Kösoğlu, Mustafa. “Propolisin İnsan Sağlığına Etkileri”. ANADOLU Journal of Aegean Agricultural Research Institute 24/2 (01 Aralık 2014): 41-49. https://izlik.org/JA67MU24ST.

JAMA

1.Yücel B, Topal E, Akçiçek E, Kösoğlu M. Propolisin İnsan Sağlığına Etkileri. ANADOLU. 2014;24:41–49.

MLA

Yücel, Banu, vd. “Propolisin İnsan Sağlığına Etkileri”. ANADOLU Journal of Aegean Agricultural Research Institute, c. 24, sy 2, Aralık 2014, ss. 41-49, https://izlik.org/JA67MU24ST.

Vancouver

1.Banu Yücel, Erkan Topal, Eren Akçiçek, Mustafa Kösoğlu. Propolisin İnsan Sağlığına Etkileri. ANADOLU [Internet]. 01 Aralık 2014;24(2):41-9. Erişim adresi: https://izlik.org/JA67MU24ST

ANADOLU Journal by Aegean Agricultural Research Institute is licensed under CC BY-NC-ND 4.0

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