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Propolisin İmmun Sistem Üzerine Etkileri

Yıl 2018, Cilt: 28 Sayı: 2, 99 - 104, 22.10.2018

Öz

ÖZ: Propolis, bal arıları tarafından toplanan bitki
reçinelerinden elde edilen doğal bir üründür. Arılar tutkal, genel amaçlı
sızdırmazlık maddesi ve arı kovanları için taslak ekstrüzyon makinesi olarak
kullanılır. Propolis yüzyıllardır halk tıbbında kullanılmıştır. Propolis'in
anti-mikrobik, antioksidatif, anti-ülser ve anti-tümör aktivitelerine sahip
olduğu bilinmektedir. Bu nedenle, propolis son yıllarda tıp ve kozmetik
ürünlerinde kullanılan yararlı veya potansiyel bir madde olarak dikkat
çekmiştir. Dahası, artık insan sağlığını koruyabileceği veya geliştirdiği
iddiasıyla gıda kumları içeceklerinde yaygın bir şekilde kullanılmaktadır.
Propolisin kimyasal bileşimi oldukça karmaşıktır. Propolis örneklerinde
polifenoller, fenolik aldehitler, sekuiterpen kininler, kumarinler, amino
asitler, steroid inorganik bileşikler gibi 300'den fazla bileşik tespit
edilmiştir. İçerik, toplanma yerine, zamana ve bitki kaynağına göre
değişebilir.  Sonuç olarak, farklı
fitocoğrafik bölgelerin farklı dönemlerinden toplanan propolisin biyolojik
faaliyetleri büyük ölçüde değişir. Propolisin kimyasal bileşimi ve faydalı
özellikleri, fitocoğrafik alanlara, mevsimlik toplama süresine ve botanik
kaynağa bağlı olarak büyük ölçüde değişir. Meyve ve sebzelerde bulunan
polifenoller, nöral hücrelerin oksidatif stres ve normal yaşlanmaya ve kronik
alyuvar hastalıklarına bağlı nöroinflamasyona karşı korunmada yaşamsal rolü
bulunur.

Kaynakça

  • Almas, K., A. Dahlan, and A. Mahmoud. 2001. A. Propolis as a natural remedy: An update. Saudi Dental Journal 13: 45-49.
  • Antúnez, K., J. Harriet, L. Gende, M. Maggi, M. Eguaras, and P. Zunino. 2008. Efficacy of natural propolis extract in the control of American Foulbrood. Vet. Microbiol. 131 (3-4): 324-331.
  • Bastos, E. M., M. Simone, D. M Jorge, A. E. Soares, and M. Spivak. 2008. In vitro study of the antimicrobial activity of Brazilian propolis against Paenibacillus larvae. J. Invertebr. Pathol. 97: 273-281.
  • Bilikova, K., M. Popova, B. Trusheva, and V. Bankova. 2013. New anti-Paenibacillus larvae substances purified from propolis. Apidologie 44: 278-285. DOI: 10. 1007/s13592-012-0178-1.
  • Burdock, G. A. 1998. Review of the biological properties and toxicity of bee propolis. Food Chem Toxicol. 36: 347-363.
  • Castaldo, S., and F. Capasso. 2002. Propolis, an old remedy used in modern medicine. Fitoterapia 73: 1-6.
  • Chopra, S., K. K. Pillai, S. Z. Husain, and D. K. Giri. 1995. Propolis protects against doxorubicin-induced myocardiopathy in rats. Exp Mol Pathol. 62: 190-198.
  • Evans, J. D., K. Aronstein, Y. P. Chen, C. Hetru, J. L. Imler, H. Jiang, M. Kanost, G. J. Thompson, Z. Zou, D. Hultmark. 2006. Immune pathways and defence mechanisms in honey bees Apis mellifera. Insect Mol. Biol. 15: 645-656.
  • El-Ghazaly, M. A., M. T. Khayyal. 1995. The use of aquueous propolis extract against radiation -induced damage. Drugs Exp Clin Res. 21: 229-236.
  • Finstrom M. S., and M. Spivak. 2010. Propolis and bee health: the natural history and significance of resin use by honey bees. Apidologie 41: 295-311.
  • Grange, J. M., and R. W. Davey. 1990. Antibacterial properties of propolis (bee glue). JR Soc Med. 83: 159-160.
  • Harish, Z., A. Rubinstein , M. Golodner , M. Elmaliah , Y. Mizrachi .1997. Supression of HIV-1 replication by propolis and its immunoregulatory effect. Drugs Exp Clin Res. 23: 89-96.
  • Johnson, R. M., Z. Wen, M. A. Schuler, and M. R. Berenbaum. 2006. Mediation of pyrethroid insecticide toxicity to honey bees (Hymenoptera: Apidae) by cytochrome P450 monooxygenases. Journal of Economic Entomology 99: 1046-1050. DOI: 10.1603/0022-0493-99.4.1046.
  • Johnson, R. M., W. Mao, H. S. Pollock, G. Niu, M. A. Schuler, and M. R. Berenbaum. 2012. Ecologically appropriate xenobiotics induce cytochrome P450s in Apis mellifera. PLoS ONE 7, e31051. https://doi.org/10.1371/journal.pone.0031051.
  • Kujumgiev, A., I. Tsverkova, Y. Serkedjieva, V. Bankova, R. Christov , S. Popov. 1999. Antibacterial, antifungal and antiviral activity of propolis of different geographic origin. Journal of Ethnopharmacology 64 (3): 235-40.
  • Koo, H., B. P. F. A. Gomes, P. L. Rosalen, G. M. B. Ambrosano, Y. K. Park, and J. A. Cury. 2000. In vitro antimicrobial activity of propolis and Arnica Montana against oral pathogens Archives of Oral Biology 45: 141-148.
  • Langenheim, J. H. 2003. Plant Resins: Chemistry, Evolution, Ecology, and Ethnobotany. Portland, OR: Timber Press.
  • Ledon, N., A. Casaco, R. Gonzales, N., A González, and Z. Tolón .1997. Antipsoriatic, anti-inflammatory, and analgesic effects of an extract of red propolis. Zhongguo Yao Li Xue Bao. 18 (3): 274-6.
  • Lin, SC., Y. H. Lin, C. F. Chen, C. Y. Chung, and S. H. Hsu. 1997. The hepatoprotective and therapeutic effects of propolis ethanol extract on chronic alcohol-induced liver injuries. Am. J. Chin. Med. 25 (3-4): 325-32. Lindenfelser, L. A. 1968. In vivo activity of propolis against Bacillus larvae. J. Invertebr. Pathol. 12: 129-131.
  • Mao, W. M. A. Schuler, and M. R. Berenbaum. 2011. CYP9Q-mediated detoxification of acaricides in the honey bee (Apis mellifera). Proc. Natl. Acad. Sci. USA 108: 12657-12662.
  • Matsuno, T., S. K. Jung, Y. Matsumoto, M. Saito, and J. Morikawa .1997. Preferential cytotoxicity to tumor cells of 3,5-diprenyl-4-hydroxycinnamic acid (artepillin C) isolated from propolis. Anticancer Res.17 (5A): 3565-8.
  • Mirzoeva, O. K., and P. C. Calder. 1996.The effect of propolis and its components on eicosanoid production during the inflammatory response. Prostaglandins Leukot Essent Fatty Acids 55 (6): 441-9.
  • Mirzoeva, OK., R. N. Grishanin, and P. C. Calder. 1997. Antimicrobial action of propolis and some of its components: the effects on growth, membrane potential and motility of bacteria. Microbiol Res. 152 (3): 239-46.
  • Nagai, T., T. Nagashima , T. Myoda, and R. Inoue .2004. Preparation and the functional properties of water extract and alkaline extract of royal jelly. Food Chem. 84: 181-186.
  • Natarajan, K., S. Singh, T. R. Burke Jr, D. Grunberger, and B. B. Aggarwal. 1996. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci U S A. 93 (17): 9090-5.
  • Nicodemo, D., D. De Jong, R. H. Couto, and E. B. Malheiros. 2013. Honey bee lines selected for high propolis production also have superior hygienic behavior and increased honey and pollen stores. Genet. Mol. Res. 12: 6931-6938. Ozturk, F., E. Kurt, M. Cerçi, L. Emiroglu, U. Inan , M. Türker, S. Ilker. 2000. The effect of propolis extract in experimental chemical corneal injury. Ophthalmic Res. 32 (1): 13-8. Park, E. H., and J. H. Kahng. 1999. Suppressive effects of propolis in rat adjuvant arthritis. Arch Pharm Res. 22 (6): 554-8. Rao, C. V., D. Desai, B. Simi, N. Kulkarni, S. Amin, and B. S. Reddy. 1993. Inhibitory effect of caffeic acid esters on azoxymethane-induced biochemical changes and aberrant crypt foci formation in rat colon. Cancer Res. 53 (18): 4182-8. Santos, F. A., E. M. A. Bastos, M. A. R. Uzeda, M. A. Carvalho, L. M. Farias, E. S. Moriera, and F. C. Braga. 2002. Antibacterial activity of Brazilian propolis and fractions against oral anaerobic bacteria Journal of Etnopharmacology 80: 1-7. Seeley, T. D., and R. A. Morse. 1976. The nest of the honey bee. lnsects. Tome 23 (4): 495-512. Simone, M., J. D. Evans, and M. Spivak 2009. Resin collection and social immunity in honey bees. Evolution 63: 3016-3022. Söderhäll, K., and L. Cerenius. 1998. Role of the prophenoloxidase-activating system in invertebrate immunity. Curr. Opin. Immunol. 10: 23-28. DOI: 10.1016/S0952-7915(98)80026-5 Sonmez, Ş., L. Kirilmaz, M. Yucesoy, B. Yucel, and B. Yılmaz. 2005. The effect of propolis in oral pathogens and human gingival fibroblasts. Journal of Ethnopharmacology 102 (3): 371-376. Strand, M. R. 2008. Insect hemocytes and their role in immunity. In Insect Immunology (ed. N. Beckage), pp. 25-47. Boston: Academic Press. Wilson, M. B., M. Spivak, A. D. Hegeman, A. Rendahl, and J. D. Cohen. 2013. Metabolomics reveals the origins of antimicrobial plant resins collected by honey bees. PLoS ONE 8, e77512. Wilson, M. B, D. Brinkman, M. Spivak, G. Gardner, and J. D. Cohen. 2015. Regional variation in composition and antimicrobial activity of US propolis against Paenibacillus larvae and Ascosphaera Apis. J. Invertebr. Pathol. 124: 44-50. Yucel, B., E. Topal, E. Akcicek ve M. Kosoglu. 2014. Propo -lisin insan sağlığına etkileri. Anadolu, J. of AARI, 24 (2): 41-49.

Effects of Propolis on Immune System

Yıl 2018, Cilt: 28 Sayı: 2, 99 - 104, 22.10.2018

Öz

ABSTRACT: Propolis is a natural product derived from plant
resins collected by honey bees. It is used by bees as glue, a general-purpose
sealer, and as draught-extruder for bee hives. Propolis has been used in folk
medicine for centuries. It is known that propolis possesses anti-microbial,
antioxidative, anti-ulcerand anti-tumor activities. Therefore, propolis has
attracted much attention in recent years as a useful or potential substance
used in medicine and cosmetics products. Furthermore, it is now extensively
used in food sand beverages with the claim that it can maintain or improve
human health. The chemical composition of propolis is quite complicated. More than
300 compounds such as polyphenols, phenolic aldehydes, sequiterpenequinines,
coumarins, amino acids, steroid sand inorganic compounds have been identified
in propolis samples. The contents depend on the collecting location, time and
plant source. Consequently, biological activities of propolis gathered from
different phytogeographical area sand time periods vary greatly. The chemical
composition and beneficial properties of propolis vary greatly depending on the
phytogeographical areas, seasonal collection time, and botanical source.
Polyphenols found in fruits and vegetables are beginning to receive increased
attention due to the vital role in protecting neural cells from oxidative
stress and neuroinflammation associated with normal aging and chronicage-related
diseases.

Kaynakça

  • Almas, K., A. Dahlan, and A. Mahmoud. 2001. A. Propolis as a natural remedy: An update. Saudi Dental Journal 13: 45-49.
  • Antúnez, K., J. Harriet, L. Gende, M. Maggi, M. Eguaras, and P. Zunino. 2008. Efficacy of natural propolis extract in the control of American Foulbrood. Vet. Microbiol. 131 (3-4): 324-331.
  • Bastos, E. M., M. Simone, D. M Jorge, A. E. Soares, and M. Spivak. 2008. In vitro study of the antimicrobial activity of Brazilian propolis against Paenibacillus larvae. J. Invertebr. Pathol. 97: 273-281.
  • Bilikova, K., M. Popova, B. Trusheva, and V. Bankova. 2013. New anti-Paenibacillus larvae substances purified from propolis. Apidologie 44: 278-285. DOI: 10. 1007/s13592-012-0178-1.
  • Burdock, G. A. 1998. Review of the biological properties and toxicity of bee propolis. Food Chem Toxicol. 36: 347-363.
  • Castaldo, S., and F. Capasso. 2002. Propolis, an old remedy used in modern medicine. Fitoterapia 73: 1-6.
  • Chopra, S., K. K. Pillai, S. Z. Husain, and D. K. Giri. 1995. Propolis protects against doxorubicin-induced myocardiopathy in rats. Exp Mol Pathol. 62: 190-198.
  • Evans, J. D., K. Aronstein, Y. P. Chen, C. Hetru, J. L. Imler, H. Jiang, M. Kanost, G. J. Thompson, Z. Zou, D. Hultmark. 2006. Immune pathways and defence mechanisms in honey bees Apis mellifera. Insect Mol. Biol. 15: 645-656.
  • El-Ghazaly, M. A., M. T. Khayyal. 1995. The use of aquueous propolis extract against radiation -induced damage. Drugs Exp Clin Res. 21: 229-236.
  • Finstrom M. S., and M. Spivak. 2010. Propolis and bee health: the natural history and significance of resin use by honey bees. Apidologie 41: 295-311.
  • Grange, J. M., and R. W. Davey. 1990. Antibacterial properties of propolis (bee glue). JR Soc Med. 83: 159-160.
  • Harish, Z., A. Rubinstein , M. Golodner , M. Elmaliah , Y. Mizrachi .1997. Supression of HIV-1 replication by propolis and its immunoregulatory effect. Drugs Exp Clin Res. 23: 89-96.
  • Johnson, R. M., Z. Wen, M. A. Schuler, and M. R. Berenbaum. 2006. Mediation of pyrethroid insecticide toxicity to honey bees (Hymenoptera: Apidae) by cytochrome P450 monooxygenases. Journal of Economic Entomology 99: 1046-1050. DOI: 10.1603/0022-0493-99.4.1046.
  • Johnson, R. M., W. Mao, H. S. Pollock, G. Niu, M. A. Schuler, and M. R. Berenbaum. 2012. Ecologically appropriate xenobiotics induce cytochrome P450s in Apis mellifera. PLoS ONE 7, e31051. https://doi.org/10.1371/journal.pone.0031051.
  • Kujumgiev, A., I. Tsverkova, Y. Serkedjieva, V. Bankova, R. Christov , S. Popov. 1999. Antibacterial, antifungal and antiviral activity of propolis of different geographic origin. Journal of Ethnopharmacology 64 (3): 235-40.
  • Koo, H., B. P. F. A. Gomes, P. L. Rosalen, G. M. B. Ambrosano, Y. K. Park, and J. A. Cury. 2000. In vitro antimicrobial activity of propolis and Arnica Montana against oral pathogens Archives of Oral Biology 45: 141-148.
  • Langenheim, J. H. 2003. Plant Resins: Chemistry, Evolution, Ecology, and Ethnobotany. Portland, OR: Timber Press.
  • Ledon, N., A. Casaco, R. Gonzales, N., A González, and Z. Tolón .1997. Antipsoriatic, anti-inflammatory, and analgesic effects of an extract of red propolis. Zhongguo Yao Li Xue Bao. 18 (3): 274-6.
  • Lin, SC., Y. H. Lin, C. F. Chen, C. Y. Chung, and S. H. Hsu. 1997. The hepatoprotective and therapeutic effects of propolis ethanol extract on chronic alcohol-induced liver injuries. Am. J. Chin. Med. 25 (3-4): 325-32. Lindenfelser, L. A. 1968. In vivo activity of propolis against Bacillus larvae. J. Invertebr. Pathol. 12: 129-131.
  • Mao, W. M. A. Schuler, and M. R. Berenbaum. 2011. CYP9Q-mediated detoxification of acaricides in the honey bee (Apis mellifera). Proc. Natl. Acad. Sci. USA 108: 12657-12662.
  • Matsuno, T., S. K. Jung, Y. Matsumoto, M. Saito, and J. Morikawa .1997. Preferential cytotoxicity to tumor cells of 3,5-diprenyl-4-hydroxycinnamic acid (artepillin C) isolated from propolis. Anticancer Res.17 (5A): 3565-8.
  • Mirzoeva, O. K., and P. C. Calder. 1996.The effect of propolis and its components on eicosanoid production during the inflammatory response. Prostaglandins Leukot Essent Fatty Acids 55 (6): 441-9.
  • Mirzoeva, OK., R. N. Grishanin, and P. C. Calder. 1997. Antimicrobial action of propolis and some of its components: the effects on growth, membrane potential and motility of bacteria. Microbiol Res. 152 (3): 239-46.
  • Nagai, T., T. Nagashima , T. Myoda, and R. Inoue .2004. Preparation and the functional properties of water extract and alkaline extract of royal jelly. Food Chem. 84: 181-186.
  • Natarajan, K., S. Singh, T. R. Burke Jr, D. Grunberger, and B. B. Aggarwal. 1996. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci U S A. 93 (17): 9090-5.
  • Nicodemo, D., D. De Jong, R. H. Couto, and E. B. Malheiros. 2013. Honey bee lines selected for high propolis production also have superior hygienic behavior and increased honey and pollen stores. Genet. Mol. Res. 12: 6931-6938. Ozturk, F., E. Kurt, M. Cerçi, L. Emiroglu, U. Inan , M. Türker, S. Ilker. 2000. The effect of propolis extract in experimental chemical corneal injury. Ophthalmic Res. 32 (1): 13-8. Park, E. H., and J. H. Kahng. 1999. Suppressive effects of propolis in rat adjuvant arthritis. Arch Pharm Res. 22 (6): 554-8. Rao, C. V., D. Desai, B. Simi, N. Kulkarni, S. Amin, and B. S. Reddy. 1993. Inhibitory effect of caffeic acid esters on azoxymethane-induced biochemical changes and aberrant crypt foci formation in rat colon. Cancer Res. 53 (18): 4182-8. Santos, F. A., E. M. A. Bastos, M. A. R. Uzeda, M. A. Carvalho, L. M. Farias, E. S. Moriera, and F. C. Braga. 2002. Antibacterial activity of Brazilian propolis and fractions against oral anaerobic bacteria Journal of Etnopharmacology 80: 1-7. Seeley, T. D., and R. A. Morse. 1976. The nest of the honey bee. lnsects. Tome 23 (4): 495-512. Simone, M., J. D. Evans, and M. Spivak 2009. Resin collection and social immunity in honey bees. Evolution 63: 3016-3022. Söderhäll, K., and L. Cerenius. 1998. Role of the prophenoloxidase-activating system in invertebrate immunity. Curr. Opin. Immunol. 10: 23-28. DOI: 10.1016/S0952-7915(98)80026-5 Sonmez, Ş., L. Kirilmaz, M. Yucesoy, B. Yucel, and B. Yılmaz. 2005. The effect of propolis in oral pathogens and human gingival fibroblasts. Journal of Ethnopharmacology 102 (3): 371-376. Strand, M. R. 2008. Insect hemocytes and their role in immunity. In Insect Immunology (ed. N. Beckage), pp. 25-47. Boston: Academic Press. Wilson, M. B., M. Spivak, A. D. Hegeman, A. Rendahl, and J. D. Cohen. 2013. Metabolomics reveals the origins of antimicrobial plant resins collected by honey bees. PLoS ONE 8, e77512. Wilson, M. B, D. Brinkman, M. Spivak, G. Gardner, and J. D. Cohen. 2015. Regional variation in composition and antimicrobial activity of US propolis against Paenibacillus larvae and Ascosphaera Apis. J. Invertebr. Pathol. 124: 44-50. Yucel, B., E. Topal, E. Akcicek ve M. Kosoglu. 2014. Propo -lisin insan sağlığına etkileri. Anadolu, J. of AARI, 24 (2): 41-49.
Toplam 26 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Makaleler
Yazarlar

Hayriye Alp

Yayımlanma Tarihi 22 Ekim 2018
Gönderilme Tarihi 29 Mart 2017
Yayımlandığı Sayı Yıl 2018 Cilt: 28 Sayı: 2

Kaynak Göster

APA Alp, H. (2018). Effects of Propolis on Immune System. ANADOLU Ege Tarımsal Araştırma Enstitüsü Dergisi, 28(2), 99-104.
AMA Alp H. Effects of Propolis on Immune System. ANADOLU. Ekim 2018;28(2):99-104.
Chicago Alp, Hayriye. “Effects of Propolis on Immune System”. ANADOLU Ege Tarımsal Araştırma Enstitüsü Dergisi 28, sy. 2 (Ekim 2018): 99-104.
EndNote Alp H (01 Ekim 2018) Effects of Propolis on Immune System. ANADOLU Ege Tarımsal Araştırma Enstitüsü Dergisi 28 2 99–104.
IEEE H. Alp, “Effects of Propolis on Immune System”, ANADOLU, c. 28, sy. 2, ss. 99–104, 2018.
ISNAD Alp, Hayriye. “Effects of Propolis on Immune System”. ANADOLU Ege Tarımsal Araştırma Enstitüsü Dergisi 28/2 (Ekim 2018), 99-104.
JAMA Alp H. Effects of Propolis on Immune System. ANADOLU. 2018;28:99–104.
MLA Alp, Hayriye. “Effects of Propolis on Immune System”. ANADOLU Ege Tarımsal Araştırma Enstitüsü Dergisi, c. 28, sy. 2, 2018, ss. 99-104.
Vancouver Alp H. Effects of Propolis on Immune System. ANADOLU. 2018;28(2):99-104.
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