A simple proof of vitamin D deficiency and inflammation relation: single center study, over two thousand patients

Yıl 2023, , 170 - 175, 23.05.2023

Ekmel Burak Özşenel , Mehmet Yavuz Gürler

https://doi.org/10.21673/anadoluklin.1228064

Öz

Aim: Vitamin D deficiency is a very common condition in the world. Although vitamin D appears to be effective mainly on calcium and bone metabolism, it is an important molecule that also affects immune functions and inflammation. In our study, we tried to evaluate the contribution of vitamin D deficiency to inflammation by examining the platelet indices of patients with low and normal vitamin D levels.

Methods: Healthy patients who applied to internal medicine outpatient clinics of our hospital for routine control in 2017 were included in our study. Patients are included in the study by following needed criteria; creatinine <1.3 mg/dl, hemoglobine >12 gr/dl, vitamin B12 >150 pg/dl, red cell distribution width <14 fL, thyroid stimulating hormone (TSH) between 1-5 IU/L and C-reactive protein (CRP) <10 mg/dl. Patients were divided into two groups, those with vitamin D less than 10 ng/ml as the study group and those above 30 ng/ml as the control group.

Results: A total of 2179 patients, 644 male and 1535 female, were included in the study. 797 patients constituted the study group (27.1% male), and 1382 patients constituted the control group (31% male). When the two groups were compared in terms of platelet indices, we found that mean platelet volume (MPV) and plateletcrit (PCT) were significantly higher in the study group (p<0.001, p<0.001).

Conclusion: In our study, we found that MPV and PCT values increased significantly with vitamin D deficiency. We attributed this result to the absence of the anti-inflammatory activity of vitamin D. As a result, treating a patient’s vitamin D deficiency can also protect patients from cardiovascular or autoimmune diseases through the anti-inflammatory effect of vitamin D.

Anahtar Kelimeler

Inflammation, mean platelet volume, platelet, Vitamin D, vitamin D deficiency

Vitamin D eksikliği ve inflamasyon ilişkisinin basit bir kanıtı: tek merkezli çalışma, iki binin üzerinde hasta

Öz

Amaç: D vitamini eksikliği dünyada çok yaygın bir durumdur. D vitamini esas olarak kalsiyum ve kemik metabolizması üzerinde etkili gibi görünse de, bağışıklık fonksiyonlarını ve inflamasyonu da etkileyen önemli bir moleküldür. Çalışmamızda D vitamini düzeyi düşük ve normal olan hastaların platelet indekslerini inceleyerek D vitamini eksikliğinin inflamasyona etkisini değerlendirmeye çalıştık.

Yöntemler: Çalışmamıza 2017 yılında hastanemiz dahiliye polikliniklerine rutin kontrol için başvuran sağlıklı hastalar dahil edildi. Hastalardan tetkik sonuçları şu kriterleri sağlayanlar çalışmaya dahil edildi; kreatinin <1,3 mg/dl, hemoglobin >12 gr/dl, vitamin B12 >150 pg/dl, kırmızı hücre dağılım genişliği (RDW) <14 fL, tiroit uyarıcı hormon (TSH) 1-5 IU/L arası ve C-reaktif protein (CRP) <10 mg/dl. Hastalar D vitamini 10 ng/ml’nin altında olanlar çalışma grubu ve 30 ng/ml’nin üzerinde olanlar kontrol grubu olarak 2 gruba ayrıldı.

Bulgular: Çalışmaya 644 erkek, 1535 kadın olmak üzere toplam 2179 hasta dahil edildi. 797 hasta çalışma grubunu (%27,1 erkek), 1382 hasta kontrol grubunu (%31 erkek) oluşturdu. Platelet indeksleri açısından iki grup karşılaştırıldığında çalışma grubunda ortalama trombosit hacmi (MPV) ve plateletokrit (PCT) anlamlı olarak daha yüksek olduğu saptandı (p<0,001, p<0,001).

Sonuç: Çalışmamızda, MPV ve PCT değerlerinin d vitamini eksikliğinde önemli ölçüde arttığını tespit ettik. Sonuç olarak, bir hastanın d vitamini eksikliğinin tedavi edilmesi, d vitamininin anti-inflamatuar etkisi ile hastayı kardiyovasküler veya otoimmün hastalıklardan da koruyabilir.

Anahtar Kelimeler

İnflamasyon, platelet, ortalama trombosit hacmi, Vitamin D, Vitamin D eksikliği

Kaynakça

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