Resveratrol in rheumatologic diseases: A narrative review

Yıl 2024, , 94 - 99, 27.01.2024

Tuba Demirci Yıldırım

https://doi.org/10.21673/anadoluklin.1376477

Öz

Resveratrol (3,5,4′-trihydroxystilbene) was first isolated from Veratrum grandiflorum by Takaoka in 1939; it is a natural polyphenol contained in plants such as grapes, strawberries, and blueberries. Many studies show that resveratrol modulates apoptosis and improves mitochondrial function by suppressing oxidative stress and inhibiting the inflammatory response. Rheumatological diseases are a heterogeneous group that includes autoimmune disease groups including systemic vasculitis such as systemic lupus erythematosus (SLE), systemic sclerosis (SSc), rheumatoid arthritis (RA), Takayasu arteritis (TA), and inflammatory arthritis such as spondyloarthritis, gouty arthritis, and osteoarthritis. The main goal of the treatment of rheumatological diseases is the suppression of inflammation. The aim of this review is to summarize recent experimental and randomized controlled clinical studies on the use and effects of resveratrol in rheumatological diseases. Resveratrol has been shown to be effective against many rheumatological diseases in experimental animal models. Although there are few studies on resveratrol in the rheumatological patient group, its use has been recommended as a supplement to traditional treatments. More studies are needed to evaluate the effectiveness, drug interactions, and side effects of resveratrol in rheumatological diseases.

Anahtar Kelimeler

Osteoarthritis, resveratrol, rheumatoid arthritis, rheumatology, systemic sclerosis

Etik Beyan

Derleme olduğu için etik kurul onayı alınmamıştır.

Destekleyen Kurum

Yoktur.

Teşekkür

Yoktur.

Romatolojik hastalıklarda resveratrol: Geleneksel derleme

Öz

Resveratrol (RE; (3,5,4′-trihydroxystilbene)) ilk olarak 1939’da Takaoka tarafından Veratrum grandiflorum’dan izole edilen; üzüm, çilek ve yaban mersini gibi bitkilerde bulunan doğal bir polifenoldür. Birçok çalışma resveratrolün oksidatif stresi baskılayıp, inflamatuar yanıtı azaltarak, mitokondriyal fonksiyonları iyileştirdiğini ve apoptozu modüle ettiğini göstermiştir. Romatolojik hastalıklar sistemik lupus eritematozus (SLE), sistemik skleroz (SSc), romatoid artrit (RA), Takayasu arteriti (TA) gibi sistemik vaskülitleri de içeren otoimmun hastalıklar grubu ile spondiloartritler, gut, osteoartrit gibi inflamatuvar artritleri de içeren heterojen bir hastalık grubudur. Romatolojik hastalıkların tedavisinde ana hedef inflamasyonun baskılanmasıdır. Bu derlemenin amacı, resveratrolün romatolojik hastalıklarda kullanımı ve etkilerine dair yayınlanmış güncel, deneysel ve randomize kontrollü klinik çalışmaları derleyerek son bilgileri özetlemektir. Resveratrolün deney hayvan modellerinde birçok romatolojik hastalığa karşı etkili olduğu gösterilmiştir. Resveratrolün, romatolojik hasta grubunda az sayıda çalışması olmakla birlikte geleneksel tedavilere destek olarak kullanımı önerilmiştir. Resveratrolün romatolojik hastalıklardaki etkinliğini, ilaç etkileşimlerini ve yan etkilerini değerlendirmek için daha fazla çalışmaya ihtiyaç vardır.

Anahtar Kelimeler

Osteoartrit, resveratrol, romatoid artrit, romatoloji, sistemik skleroz

Kaynakça

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